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High RSF1 protein expression is an independent prognostic feature in prostate cancer

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High RSF1 protein expression is an independent prognostic feature in prostate cancer. / Höflmayer, Doris; Hamuda, Moslim; Schroeder, Cornelia; Hube-Magg, Claudia; Simon, Ronald; Göbel, Cosima; Hinsch, Andrea; Weidemann, Sören; Möller, Katharina; Izbicki, Jacob R; Jacobsen, Frank; Mandelkow, Tim; Blessin, Niclas C; Lutz, Florian; Viehweger, Florian; Sauter, Guido; Burandt, Eike; Lebok, Patrick; Lennartz, Maximillian; Fraune, Christoph; Minner, Sarah; Bonk, Sarah; Huland, Hartwig; Graefen, Markus; Schlomm, Thorsten; Büscheck, Franziska.

In: ACTA ONCOL, Vol. 59, No. 3, 03.2020, p. 268-273.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Höflmayer, D, Hamuda, M, Schroeder, C, Hube-Magg, C, Simon, R, Göbel, C, Hinsch, A, Weidemann, S, Möller, K, Izbicki, JR, Jacobsen, F, Mandelkow, T, Blessin, NC, Lutz, F, Viehweger, F, Sauter, G, Burandt, E, Lebok, P, Lennartz, M, Fraune, C, Minner, S, Bonk, S, Huland, H, Graefen, M, Schlomm, T & Büscheck, F 2020, 'High RSF1 protein expression is an independent prognostic feature in prostate cancer', ACTA ONCOL, vol. 59, no. 3, pp. 268-273. https://doi.org/10.1080/0284186X.2019.1686537

APA

Höflmayer, D., Hamuda, M., Schroeder, C., Hube-Magg, C., Simon, R., Göbel, C., Hinsch, A., Weidemann, S., Möller, K., Izbicki, J. R., Jacobsen, F., Mandelkow, T., Blessin, N. C., Lutz, F., Viehweger, F., Sauter, G., Burandt, E., Lebok, P., Lennartz, M., ... Büscheck, F. (2020). High RSF1 protein expression is an independent prognostic feature in prostate cancer. ACTA ONCOL, 59(3), 268-273. https://doi.org/10.1080/0284186X.2019.1686537

Vancouver

Höflmayer D, Hamuda M, Schroeder C, Hube-Magg C, Simon R, Göbel C et al. High RSF1 protein expression is an independent prognostic feature in prostate cancer. ACTA ONCOL. 2020 Mar;59(3):268-273. https://doi.org/10.1080/0284186X.2019.1686537

Bibtex

@article{103178932dfe49b69abbaa5066062960,
title = "High RSF1 protein expression is an independent prognostic feature in prostate cancer",
abstract = "Background: Remodelling and spacing factor 1 (RSF1) is involved in the regulation of chromatin remodelling and represents a potential therapeutic target. High RSF1 expression has been linked to adverse tumour features in many cancer types, but its role in prostate cancer is uncertain.Methods: In this study, RSF1 expression was analysed by immunohistochemistry on a tissue microarray with 17,747 prostate cancers.Results: Nuclear RSF1 staining of 16,456 interpetable cancers was considered strong, moderate, weak and negative in 25.2%, 48.7%, 5.3% and 20.8% of cancers respectively. Positive RSF1 expression was associated with advanced tumour stage, high Gleason grade, lymph node metastasis (p < .0001 each), early biochemical recurrence (p < .0003) and more frequent in the ERG positive than in the ERG negative subset (88% versus 71%; p < .0001). Subset analysis revealed, that associations between RSF1 expression and unfavourable tumour phenotype and PSA recurrence were present in both subgroups but stronger in the ERG negative than in the ERG positive subset. The univariate Cox proportional hazard ratio for PSA recurrence-free survival for strong versus negative RSF1 expression was a weak 1.60 compared with 5.91 for the biopsy Gleason grade ≥4 + 4 versus ≤3 + 3. The positive association of RSF1 protein detection with deletion of 3p13, 10q23 (PTEN), 12p13, 16q23, and 17p13 (p < .0001 each) suggest a role of high RSF1 expression in the development of genomic instability.Conclusion: In summary, the results of our study identify RSF1 as an independent prognostic marker in prostate cancer with a particularly strong role in ERG negative cases.",
author = "Doris H{\"o}flmayer and Moslim Hamuda and Cornelia Schroeder and Claudia Hube-Magg and Ronald Simon and Cosima G{\"o}bel and Andrea Hinsch and S{\"o}ren Weidemann and Katharina M{\"o}ller and Izbicki, {Jacob R} and Frank Jacobsen and Tim Mandelkow and Blessin, {Niclas C} and Florian Lutz and Florian Viehweger and Guido Sauter and Eike Burandt and Patrick Lebok and Maximillian Lennartz and Christoph Fraune and Sarah Minner and Sarah Bonk and Hartwig Huland and Markus Graefen and Thorsten Schlomm and Franziska B{\"u}scheck",
year = "2020",
month = mar,
doi = "10.1080/0284186X.2019.1686537",
language = "English",
volume = "59",
pages = "268--273",
journal = "ACTA ONCOL",
issn = "0284-186X",
publisher = "informa healthcare",
number = "3",

}

RIS

TY - JOUR

T1 - High RSF1 protein expression is an independent prognostic feature in prostate cancer

AU - Höflmayer, Doris

AU - Hamuda, Moslim

AU - Schroeder, Cornelia

AU - Hube-Magg, Claudia

AU - Simon, Ronald

AU - Göbel, Cosima

AU - Hinsch, Andrea

AU - Weidemann, Sören

AU - Möller, Katharina

AU - Izbicki, Jacob R

AU - Jacobsen, Frank

AU - Mandelkow, Tim

AU - Blessin, Niclas C

AU - Lutz, Florian

AU - Viehweger, Florian

AU - Sauter, Guido

AU - Burandt, Eike

AU - Lebok, Patrick

AU - Lennartz, Maximillian

AU - Fraune, Christoph

AU - Minner, Sarah

AU - Bonk, Sarah

AU - Huland, Hartwig

AU - Graefen, Markus

AU - Schlomm, Thorsten

AU - Büscheck, Franziska

PY - 2020/3

Y1 - 2020/3

N2 - Background: Remodelling and spacing factor 1 (RSF1) is involved in the regulation of chromatin remodelling and represents a potential therapeutic target. High RSF1 expression has been linked to adverse tumour features in many cancer types, but its role in prostate cancer is uncertain.Methods: In this study, RSF1 expression was analysed by immunohistochemistry on a tissue microarray with 17,747 prostate cancers.Results: Nuclear RSF1 staining of 16,456 interpetable cancers was considered strong, moderate, weak and negative in 25.2%, 48.7%, 5.3% and 20.8% of cancers respectively. Positive RSF1 expression was associated with advanced tumour stage, high Gleason grade, lymph node metastasis (p < .0001 each), early biochemical recurrence (p < .0003) and more frequent in the ERG positive than in the ERG negative subset (88% versus 71%; p < .0001). Subset analysis revealed, that associations between RSF1 expression and unfavourable tumour phenotype and PSA recurrence were present in both subgroups but stronger in the ERG negative than in the ERG positive subset. The univariate Cox proportional hazard ratio for PSA recurrence-free survival for strong versus negative RSF1 expression was a weak 1.60 compared with 5.91 for the biopsy Gleason grade ≥4 + 4 versus ≤3 + 3. The positive association of RSF1 protein detection with deletion of 3p13, 10q23 (PTEN), 12p13, 16q23, and 17p13 (p < .0001 each) suggest a role of high RSF1 expression in the development of genomic instability.Conclusion: In summary, the results of our study identify RSF1 as an independent prognostic marker in prostate cancer with a particularly strong role in ERG negative cases.

AB - Background: Remodelling and spacing factor 1 (RSF1) is involved in the regulation of chromatin remodelling and represents a potential therapeutic target. High RSF1 expression has been linked to adverse tumour features in many cancer types, but its role in prostate cancer is uncertain.Methods: In this study, RSF1 expression was analysed by immunohistochemistry on a tissue microarray with 17,747 prostate cancers.Results: Nuclear RSF1 staining of 16,456 interpetable cancers was considered strong, moderate, weak and negative in 25.2%, 48.7%, 5.3% and 20.8% of cancers respectively. Positive RSF1 expression was associated with advanced tumour stage, high Gleason grade, lymph node metastasis (p < .0001 each), early biochemical recurrence (p < .0003) and more frequent in the ERG positive than in the ERG negative subset (88% versus 71%; p < .0001). Subset analysis revealed, that associations between RSF1 expression and unfavourable tumour phenotype and PSA recurrence were present in both subgroups but stronger in the ERG negative than in the ERG positive subset. The univariate Cox proportional hazard ratio for PSA recurrence-free survival for strong versus negative RSF1 expression was a weak 1.60 compared with 5.91 for the biopsy Gleason grade ≥4 + 4 versus ≤3 + 3. The positive association of RSF1 protein detection with deletion of 3p13, 10q23 (PTEN), 12p13, 16q23, and 17p13 (p < .0001 each) suggest a role of high RSF1 expression in the development of genomic instability.Conclusion: In summary, the results of our study identify RSF1 as an independent prognostic marker in prostate cancer with a particularly strong role in ERG negative cases.

U2 - 10.1080/0284186X.2019.1686537

DO - 10.1080/0284186X.2019.1686537

M3 - SCORING: Journal article

C2 - 31687881

VL - 59

SP - 268

EP - 273

JO - ACTA ONCOL

JF - ACTA ONCOL

SN - 0284-186X

IS - 3

ER -