High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia.
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High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia. / Troeger, Anja; Gudowius, Sonja; Escherich, Gabriele; Boer, den; Monique, L; Glouchkova, Ludmila; Ackermann, Birgit; Meisel, Roland; Laws, Hans-Juergen; Groeger, Marketa; Wessalowski, Ruediger; Willers, Reinhart; Harbott, Jochen; Pieters, Rob; Janka-Schaub, Gritta; Janka-Schaub, Gritta E; Hanenberg, Helmut; Dilloo, Dagmar.
In: BRIT J HAEMATOL, Vol. 139, No. 3, 3, 2007, p. 450-457.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - High nerve growth factor receptor (p75NTR) expression is a favourable prognostic factor in paediatric B cell precursor-acute lymphoblastic leukaemia.
AU - Troeger, Anja
AU - Gudowius, Sonja
AU - Escherich, Gabriele
AU - Boer, den
AU - Monique, L
AU - Glouchkova, Ludmila
AU - Ackermann, Birgit
AU - Meisel, Roland
AU - Laws, Hans-Juergen
AU - Groeger, Marketa
AU - Wessalowski, Ruediger
AU - Willers, Reinhart
AU - Harbott, Jochen
AU - Pieters, Rob
AU - Janka-Schaub, Gritta
AU - Janka-Schaub, Gritta E
AU - Hanenberg, Helmut
AU - Dilloo, Dagmar
PY - 2007
Y1 - 2007
N2 - Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti-proliferative signals. In spite of its established role in B-cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor-acute lymphoblastic leukaemia (BCP-ALL). p75NTR expression was prospectively studied on primary ALL-blasts in a cohort of paediatric patients with common ALL (n = 86) and preB-ALL (n = 34) treated within the Co-operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06-97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR (
AB - Nerve growth factor (NGF) plays a pivotal role in cellular survival/death decisions with the low affinity receptor p75NTR predominately transmitting anti-proliferative signals. In spite of its established role in B-cell function and identification as a prognostically favourable marker in a number of malignancies, little is known about the expression pattern and prognostic significance of p75NTR in B cell precursor-acute lymphoblastic leukaemia (BCP-ALL). p75NTR expression was prospectively studied on primary ALL-blasts in a cohort of paediatric patients with common ALL (n = 86) and preB-ALL (n = 34) treated within the Co-operative study group for childhood acute lymphoblastic leukaemia (CoALL) protocol, CoALL06-97. Flow cytometric analysis showed that almost half of the patients expressed no or negligible amounts of p75NTR (
M3 - SCORING: Zeitschriftenaufsatz
VL - 139
SP - 450
EP - 457
JO - BRIT J HAEMATOL
JF - BRIT J HAEMATOL
SN - 0007-1048
IS - 3
M1 - 3
ER -