High Ki67 expression is an independent good prognostic marker in colorectal cancer
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High Ki67 expression is an independent good prognostic marker in colorectal cancer. / Melling, Nathaniel; Kowitz, Charlotte Marie; Simon, Ronald; Bokemeyer, Carsten; Terracciano, Luigi; Sauter, Guido; Izbicki, Jakob Robert; Marx, Andreas Holger.
In: J CLIN PATHOL, Vol. 69, No. 3, 03.2016, p. 209-14.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - High Ki67 expression is an independent good prognostic marker in colorectal cancer
AU - Melling, Nathaniel
AU - Kowitz, Charlotte Marie
AU - Simon, Ronald
AU - Bokemeyer, Carsten
AU - Terracciano, Luigi
AU - Sauter, Guido
AU - Izbicki, Jakob Robert
AU - Marx, Andreas Holger
N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
PY - 2016/3
Y1 - 2016/3
N2 - AIMS: To correlate Ki67 expression with outcome in colorectal cancer (CRC).METHODS: Ki67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.RESULTS: Ki67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p<0.0001) and nodal status (p=0.0315), but not with tumour grade (p=0.8639), histological tumour type (p=0.1542) or tumour localisation, and was an independent prognosticator of favourable survival (p=0.0121). High Ki67 expression was also significantly associated with high-level nuclear β-catenin and p53 expression (p<0.0001 and p=0.0095, respectively).CONCLUSIONS: In summary, our data show that high Ki67 expression in CRCs is associated with good clinical outcome. Ki67, p53 and β-catenin overexpression seem to be linked to CRC, and indicate a cellular state of high proliferative activity. Finally, our findings strongly argue for a clinical utility of Ki67 immunostaining as an independent prognostic biomarker in CRC.
AB - AIMS: To correlate Ki67 expression with outcome in colorectal cancer (CRC).METHODS: Ki67 labelling index (Ki67LI) was analysed by immunohistochemistry on a tissue microarray containing 1800 CRCs. The results were compared with clinicopathological and molecular parameters.RESULTS: Ki67LI was considered low in 26.3%, moderate in 56.7% and high in 17.0% of 1653 interpretable CRCs. High Ki67 expression was associated with low tumour stage (p<0.0001) and nodal status (p=0.0315), but not with tumour grade (p=0.8639), histological tumour type (p=0.1542) or tumour localisation, and was an independent prognosticator of favourable survival (p=0.0121). High Ki67 expression was also significantly associated with high-level nuclear β-catenin and p53 expression (p<0.0001 and p=0.0095, respectively).CONCLUSIONS: In summary, our data show that high Ki67 expression in CRCs is associated with good clinical outcome. Ki67, p53 and β-catenin overexpression seem to be linked to CRC, and indicate a cellular state of high proliferative activity. Finally, our findings strongly argue for a clinical utility of Ki67 immunostaining as an independent prognostic biomarker in CRC.
U2 - 10.1136/jclinpath-2015-202985
DO - 10.1136/jclinpath-2015-202985
M3 - SCORING: Journal article
C2 - 26281861
VL - 69
SP - 209
EP - 214
JO - J CLIN PATHOL
JF - J CLIN PATHOL
SN - 0021-9746
IS - 3
ER -
