High Frequency of Aneuploidy Defines Ulcerative Colitis-Associated Carcinomas
Standard
High Frequency of Aneuploidy Defines Ulcerative Colitis-Associated Carcinomas : A Prognostic Comparison to Sporadic Colorectal Carcinomas. / Gerling, Marco; Meyer, Karl F; Fuchs, Katrin; Igl, Bernd W; Fritzsche, Britta; Ziegler, Andreas; Bader, F; Kujath, Peter; Schimmelpenning, Hendrik; Bruch, Hans-Peter; Roblick, Uwe J; Habermann, Jens K.
In: ANN SURG, Vol. 252, No. 1, 07.2010, p. 74-83.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - High Frequency of Aneuploidy Defines Ulcerative Colitis-Associated Carcinomas
T2 - A Prognostic Comparison to Sporadic Colorectal Carcinomas
AU - Gerling, Marco
AU - Meyer, Karl F
AU - Fuchs, Katrin
AU - Igl, Bernd W
AU - Fritzsche, Britta
AU - Ziegler, Andreas
AU - Bader, F
AU - Kujath, Peter
AU - Schimmelpenning, Hendrik
AU - Bruch, Hans-Peter
AU - Roblick, Uwe J
AU - Habermann, Jens K
PY - 2010/7
Y1 - 2010/7
N2 - OBJECTIVE: Aneuploidy is an independent risk factor for forthcoming carcinogenesis in ulcerative colitis (UC). An inferior prognosis of patients with ulcerative colitis-associated colorectal cancer (UCC) compared with those with sporadic colorectal cancer (SCC) has been reported, but remains controversial. This prompted us to investigate if aneuploidy can be observed in UCCs as frequently as in their sporadic counterpart and if aneuploidy per se might be a driving feature of poor prognosis in UCC.BACKGROUND DATA: We obtained clinical follow-up for 257 SCC patients (average observation time 57 months) and 31 UCC patients (51 months). Touch preparation slides or tissue sections were prepared of all 288 carcinomas for ploidy analysis.METHODS: Ploidy status was assessed for 260 SCCs and 31 UCCs by image cytometry and correlated to clinical features. Survival data were analyzed using Kaplan-Meier estimates.RESULTS: Aneuploidy was detected in 74.6% of SCCs and in all 31 UCCs. Logistic regression analysis yielded age (odds ratio [OR], 1.05; 95% CI, 1.02-1.09; P = 0.003) and aneuploidy (OR, 4.07; 95% CI, 1.46-11.36; P = 0.007) as independent prognostic factors for R0-resected patients devoid of metastases. Diploid SCCs had a more favorable 5-year survival (88.2%) than aneuploid SCCs (69.0%) and UCCs (73.1%) (P = 0.074).CONCLUSIONS: UC-associated carcinomas presented aneuploidy at significantly higher frequency than sporadic colorectal carcinomas (P < 0.0006). UCCs and aneuploid SCCs share a similar prognosis inferior to that of diploid SCCs. Aneuploidy proved to be the strongest independent prognostic marker for R0-resected colorectal cancer patients overall.
AB - OBJECTIVE: Aneuploidy is an independent risk factor for forthcoming carcinogenesis in ulcerative colitis (UC). An inferior prognosis of patients with ulcerative colitis-associated colorectal cancer (UCC) compared with those with sporadic colorectal cancer (SCC) has been reported, but remains controversial. This prompted us to investigate if aneuploidy can be observed in UCCs as frequently as in their sporadic counterpart and if aneuploidy per se might be a driving feature of poor prognosis in UCC.BACKGROUND DATA: We obtained clinical follow-up for 257 SCC patients (average observation time 57 months) and 31 UCC patients (51 months). Touch preparation slides or tissue sections were prepared of all 288 carcinomas for ploidy analysis.METHODS: Ploidy status was assessed for 260 SCCs and 31 UCCs by image cytometry and correlated to clinical features. Survival data were analyzed using Kaplan-Meier estimates.RESULTS: Aneuploidy was detected in 74.6% of SCCs and in all 31 UCCs. Logistic regression analysis yielded age (odds ratio [OR], 1.05; 95% CI, 1.02-1.09; P = 0.003) and aneuploidy (OR, 4.07; 95% CI, 1.46-11.36; P = 0.007) as independent prognostic factors for R0-resected patients devoid of metastases. Diploid SCCs had a more favorable 5-year survival (88.2%) than aneuploid SCCs (69.0%) and UCCs (73.1%) (P = 0.074).CONCLUSIONS: UC-associated carcinomas presented aneuploidy at significantly higher frequency than sporadic colorectal carcinomas (P < 0.0006). UCCs and aneuploid SCCs share a similar prognosis inferior to that of diploid SCCs. Aneuploidy proved to be the strongest independent prognostic marker for R0-resected colorectal cancer patients overall.
KW - Aged
KW - Aneuploidy
KW - Colitis, Ulcerative
KW - Colorectal Neoplasms
KW - DNA, Neoplasm
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Prognosis
KW - Comparative Study
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1097/SLA.0b013e3181deb664
DO - 10.1097/SLA.0b013e3181deb664
M3 - SCORING: Journal article
C2 - 20531006
VL - 252
SP - 74
EP - 83
JO - ANN SURG
JF - ANN SURG
SN - 0003-4932
IS - 1
ER -
