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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

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High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study. / Schroeder, Maria; Schaumburg, Berfin; Mueller, Zacharias; Parplys, Ann; Jarczak, Dominik; Roedl, Kevin; Nierhaus, Axel; Heer, Geraldine de; Grensemann, Joern; Schneider, Bettina; Stoll, Fabian; Bai, Tian; Jacobsen, Henning; Zickler, Martin; Stanelle-Bertram, Stephanie; Klaetschke, Kristin; Renné, Thomas; Meinhardt, Andreas; Aberle, Jens; Hiller, Jens; Peine, Sven; Kreienbrock, Lothar; Klingel, Karin; Kluge, Stefan; Gabriel, Guelsah.

In: EMERG MICROBES INFEC, Vol. 10, No. 1, 12.2021, p. 1807-1818.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schroeder, M, Schaumburg, B, Mueller, Z, Parplys, A, Jarczak, D, Roedl, K, Nierhaus, A, Heer, GD, Grensemann, J, Schneider, B, Stoll, F, Bai, T, Jacobsen, H, Zickler, M, Stanelle-Bertram, S, Klaetschke, K, Renné, T, Meinhardt, A, Aberle, J, Hiller, J, Peine, S, Kreienbrock, L, Klingel, K, Kluge, S & Gabriel, G 2021, 'High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study', EMERG MICROBES INFEC, vol. 10, no. 1, pp. 1807-1818. https://doi.org/10.1080/22221751.2021.1969869

APA

Schroeder, M., Schaumburg, B., Mueller, Z., Parplys, A., Jarczak, D., Roedl, K., Nierhaus, A., Heer, G. D., Grensemann, J., Schneider, B., Stoll, F., Bai, T., Jacobsen, H., Zickler, M., Stanelle-Bertram, S., Klaetschke, K., Renné, T., Meinhardt, A., Aberle, J., ... Gabriel, G. (2021). High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study. EMERG MICROBES INFEC, 10(1), 1807-1818. https://doi.org/10.1080/22221751.2021.1969869

Vancouver

Schroeder M, Schaumburg B, Mueller Z, Parplys A, Jarczak D, Roedl K et al. High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study. EMERG MICROBES INFEC. 2021 Dec;10(1):1807-1818. https://doi.org/10.1080/22221751.2021.1969869

Bibtex

@article{c6006738910d43daae5091275386d4bc,
title = "High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study",
abstract = "Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients.",
author = "Maria Schroeder and Berfin Schaumburg and Zacharias Mueller and Ann Parplys and Dominik Jarczak and Kevin Roedl and Axel Nierhaus and Heer, {Geraldine de} and Joern Grensemann and Bettina Schneider and Fabian Stoll and Tian Bai and Henning Jacobsen and Martin Zickler and Stephanie Stanelle-Bertram and Kristin Klaetschke and Thomas Renn{\'e} and Andreas Meinhardt and Jens Aberle and Jens Hiller and Sven Peine and Lothar Kreienbrock and Karin Klingel and Stefan Kluge and Guelsah Gabriel",
year = "2021",
month = dec,
doi = "10.1080/22221751.2021.1969869",
language = "English",
volume = "10",
pages = "1807--1818",
journal = "EMERG MICROBES INFEC",
issn = "2222-1751",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - High estradiol and low testosterone levels are associated with critical illness in male but not in female COVID-19 patients: a retrospective cohort study

AU - Schroeder, Maria

AU - Schaumburg, Berfin

AU - Mueller, Zacharias

AU - Parplys, Ann

AU - Jarczak, Dominik

AU - Roedl, Kevin

AU - Nierhaus, Axel

AU - Heer, Geraldine de

AU - Grensemann, Joern

AU - Schneider, Bettina

AU - Stoll, Fabian

AU - Bai, Tian

AU - Jacobsen, Henning

AU - Zickler, Martin

AU - Stanelle-Bertram, Stephanie

AU - Klaetschke, Kristin

AU - Renné, Thomas

AU - Meinhardt, Andreas

AU - Aberle, Jens

AU - Hiller, Jens

AU - Peine, Sven

AU - Kreienbrock, Lothar

AU - Klingel, Karin

AU - Kluge, Stefan

AU - Gabriel, Guelsah

PY - 2021/12

Y1 - 2021/12

N2 - Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients.

AB - Male sex was repeatedly identified as a risk factor for death and intensive care admission. However, it is yet unclear whether sex hormones are associated with disease severity in COVID-19 patients. In this study, we analysed sex hormone levels (estradiol and testosterone) of male and female COVID-19 patients (n = 50) admitted to an intensive care unit (ICU) in comparison to control non-COVID-19 patients at the ICU (n = 42), non-COVID-19 patients with the most prevalent comorbidity (coronary heart diseases) present within the COVID-19 cohort (n = 39) and healthy individuals (n = 50). We detected significantly elevated estradiol levels in critically ill male COVID-19 patients compared to all control cohorts. Testosterone levels were significantly reduced in critically ill male COVID-19 patients compared to control cohorts. No statistically significant differences in sex hormone levels were detected in critically ill female COVID-19 patients, albeit similar trends towards elevated estradiol levels were observed. Linear regression analysis revealed that among a broad range of cytokines and chemokines analysed, IFN-γ levels are positively associated with estradiol levels in male and female COVID-19 patients. Furthermore, male COVID-19 patients with elevated estradiol levels were more likely to receive ECMO treatment. Thus, we herein identified that disturbance of sex hormone metabolism might present a hallmark in critically ill male COVID-19 patients.

U2 - 10.1080/22221751.2021.1969869

DO - 10.1080/22221751.2021.1969869

M3 - SCORING: Journal article

C2 - 34402750

VL - 10

SP - 1807

EP - 1818

JO - EMERG MICROBES INFEC

JF - EMERG MICROBES INFEC

SN - 2222-1751

IS - 1

ER -