Heyde syndrome: treat aortic valve disease to stop gastrointestinal bleeding?
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Heyde syndrome: treat aortic valve disease to stop gastrointestinal bleeding? / Waldschmidt, Lara; Seiffert, Moritz.
In: EUR HEART J, Vol. 44, No. 33, 01.09.2023, p. 3178–3180.Research output: SCORING: Contribution to journal › Editorial › Research
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TY - JOUR
T1 - Heyde syndrome: treat aortic valve disease to stop gastrointestinal bleeding?
AU - Waldschmidt, Lara
AU - Seiffert, Moritz
PY - 2023/9/1
Y1 - 2023/9/1
N2 - Heyde syndrome is the association of aortic stenosis and gastrointestinal bleeding (GIB) from angiodysplasia, accompanied by acquired von Willebrand syndrome (aVWS) leading to decreased levels of high molecular weight multimers (HMWMs). The development of angiodysplasia in the gastrointestinal tract remains unclear. Mucosal ischaemia, high shear stress resulting from turbulence caused by the stenotic valve, and the presence of aVWS may be involved. Aortic valve replacement through surgical replacement (SAVR) or transcatheter aortic valve implantation (TAVI) leads to decreased shear stress and may resolve GIB through recovery of aVWS and potentially dissolving angiodysplasias.
AB - Heyde syndrome is the association of aortic stenosis and gastrointestinal bleeding (GIB) from angiodysplasia, accompanied by acquired von Willebrand syndrome (aVWS) leading to decreased levels of high molecular weight multimers (HMWMs). The development of angiodysplasia in the gastrointestinal tract remains unclear. Mucosal ischaemia, high shear stress resulting from turbulence caused by the stenotic valve, and the presence of aVWS may be involved. Aortic valve replacement through surgical replacement (SAVR) or transcatheter aortic valve implantation (TAVI) leads to decreased shear stress and may resolve GIB through recovery of aVWS and potentially dissolving angiodysplasias.
U2 - 10.1093/eurheartj/ehad277
DO - 10.1093/eurheartj/ehad277
M3 - Editorial
C2 - 37403478
VL - 44
SP - 3178
EP - 3180
JO - EUR HEART J
JF - EUR HEART J
SN - 0195-668X
IS - 33
ER -