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Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation

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Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation. / Waldschmidt, Lara; Drolz, Andreas; Heimburg, Paula; Goßling, Alina; Ludwig, Sebastian; Voigtländer, Lisa; Linder, Matthias; Schofer, Niklas; Reichenspurner, Hermann; Blankenberg, Stefan; Westermann, Dirk; Conradi, Lenard; Kluwe, Johannes; Seiffert, Moritz.

In: CLIN RES CARDIOL, Vol. 110, No. 12, 12.2021, p. 1939-1946.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Waldschmidt, L, Drolz, A, Heimburg, P, Goßling, A, Ludwig, S, Voigtländer, L, Linder, M, Schofer, N, Reichenspurner, H, Blankenberg, S, Westermann, D, Conradi, L, Kluwe, J & Seiffert, M 2021, 'Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation', CLIN RES CARDIOL, vol. 110, no. 12, pp. 1939-1946. https://doi.org/10.1007/s00392-021-01905-z

APA

Waldschmidt, L., Drolz, A., Heimburg, P., Goßling, A., Ludwig, S., Voigtländer, L., Linder, M., Schofer, N., Reichenspurner, H., Blankenberg, S., Westermann, D., Conradi, L., Kluwe, J., & Seiffert, M. (2021). Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation. CLIN RES CARDIOL, 110(12), 1939-1946. https://doi.org/10.1007/s00392-021-01905-z

Vancouver

Waldschmidt L, Drolz A, Heimburg P, Goßling A, Ludwig S, Voigtländer L et al. Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation. CLIN RES CARDIOL. 2021 Dec;110(12):1939-1946. https://doi.org/10.1007/s00392-021-01905-z

Bibtex

@article{ae78ada7b23b40b1847367705d584ba2,
title = "Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation",
abstract = "BACKGROUND: Heyde syndrome (HS) is known as the association of severe aortic stenosis (AS) and recurrent gastrointestinal bleeding (GIB) from angiodysplasia. Data on the prevalence of HS and results after TAVI remain scarce.METHODS: 2548 consecutive patients who underwent TAVI for the treatment of AS from 2008 to 2017 were evaluated for a history of GIB and the presence of HS. The diagnosis of HS was defined as a clinical triad of severe AS, a history of recurrent GIB, and an endoscopic diagnosis of angiodysplasia. These patients (Heyde) were followed to investigate clinical outcomes, bleeding complications and the recurrence of GIB and were compared to patients with GIB unrelated to HS (Non-Heyde).RESULTS: A history of GIB prior to TAVI was detected in 190 patients (7.5%). Among them, 47 patients were diagnosed with HS (1.8%). Heyde patients required blood transfusions more frequently compared to Non-Heyde patients during index hospitalization (50.0% vs. 31.9%, p = 0.03). Recurrent GIB was detected in 39.8% of Heyde compared to 21.2% of Non-Heyde patients one year after TAVI (p = 0.03). In patients diagnosed with HS and recurrent GIB after TAVI, the rate of residual ≥ mild paravalvular leakage (PVL) was higher compared to those without recurrent bleeding (73.3% vs. 38.1%, p = 0.05).CONCLUSION: A relevant number of patients undergoing TAVI were diagnosed with HS. Recurrent GIB was detected in a significant number of Heyde patients during follow-up. A possible association with residual PVL requires further investigation to improve treatment options and outcomes in patients with HS.",
author = "Lara Waldschmidt and Andreas Drolz and Paula Heimburg and Alina Go{\ss}ling and Sebastian Ludwig and Lisa Voigtl{\"a}nder and Matthias Linder and Niklas Schofer and Hermann Reichenspurner and Stefan Blankenberg and Dirk Westermann and Lenard Conradi and Johannes Kluwe and Moritz Seiffert",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = dec,
doi = "10.1007/s00392-021-01905-z",
language = "English",
volume = "110",
pages = "1939--1946",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "12",

}

RIS

TY - JOUR

T1 - Heyde syndrome: prevalence and outcomes in patients undergoing transcatheter aortic valve implantation

AU - Waldschmidt, Lara

AU - Drolz, Andreas

AU - Heimburg, Paula

AU - Goßling, Alina

AU - Ludwig, Sebastian

AU - Voigtländer, Lisa

AU - Linder, Matthias

AU - Schofer, Niklas

AU - Reichenspurner, Hermann

AU - Blankenberg, Stefan

AU - Westermann, Dirk

AU - Conradi, Lenard

AU - Kluwe, Johannes

AU - Seiffert, Moritz

N1 - © 2021. The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - BACKGROUND: Heyde syndrome (HS) is known as the association of severe aortic stenosis (AS) and recurrent gastrointestinal bleeding (GIB) from angiodysplasia. Data on the prevalence of HS and results after TAVI remain scarce.METHODS: 2548 consecutive patients who underwent TAVI for the treatment of AS from 2008 to 2017 were evaluated for a history of GIB and the presence of HS. The diagnosis of HS was defined as a clinical triad of severe AS, a history of recurrent GIB, and an endoscopic diagnosis of angiodysplasia. These patients (Heyde) were followed to investigate clinical outcomes, bleeding complications and the recurrence of GIB and were compared to patients with GIB unrelated to HS (Non-Heyde).RESULTS: A history of GIB prior to TAVI was detected in 190 patients (7.5%). Among them, 47 patients were diagnosed with HS (1.8%). Heyde patients required blood transfusions more frequently compared to Non-Heyde patients during index hospitalization (50.0% vs. 31.9%, p = 0.03). Recurrent GIB was detected in 39.8% of Heyde compared to 21.2% of Non-Heyde patients one year after TAVI (p = 0.03). In patients diagnosed with HS and recurrent GIB after TAVI, the rate of residual ≥ mild paravalvular leakage (PVL) was higher compared to those without recurrent bleeding (73.3% vs. 38.1%, p = 0.05).CONCLUSION: A relevant number of patients undergoing TAVI were diagnosed with HS. Recurrent GIB was detected in a significant number of Heyde patients during follow-up. A possible association with residual PVL requires further investigation to improve treatment options and outcomes in patients with HS.

AB - BACKGROUND: Heyde syndrome (HS) is known as the association of severe aortic stenosis (AS) and recurrent gastrointestinal bleeding (GIB) from angiodysplasia. Data on the prevalence of HS and results after TAVI remain scarce.METHODS: 2548 consecutive patients who underwent TAVI for the treatment of AS from 2008 to 2017 were evaluated for a history of GIB and the presence of HS. The diagnosis of HS was defined as a clinical triad of severe AS, a history of recurrent GIB, and an endoscopic diagnosis of angiodysplasia. These patients (Heyde) were followed to investigate clinical outcomes, bleeding complications and the recurrence of GIB and were compared to patients with GIB unrelated to HS (Non-Heyde).RESULTS: A history of GIB prior to TAVI was detected in 190 patients (7.5%). Among them, 47 patients were diagnosed with HS (1.8%). Heyde patients required blood transfusions more frequently compared to Non-Heyde patients during index hospitalization (50.0% vs. 31.9%, p = 0.03). Recurrent GIB was detected in 39.8% of Heyde compared to 21.2% of Non-Heyde patients one year after TAVI (p = 0.03). In patients diagnosed with HS and recurrent GIB after TAVI, the rate of residual ≥ mild paravalvular leakage (PVL) was higher compared to those without recurrent bleeding (73.3% vs. 38.1%, p = 0.05).CONCLUSION: A relevant number of patients undergoing TAVI were diagnosed with HS. Recurrent GIB was detected in a significant number of Heyde patients during follow-up. A possible association with residual PVL requires further investigation to improve treatment options and outcomes in patients with HS.

U2 - 10.1007/s00392-021-01905-z

DO - 10.1007/s00392-021-01905-z

M3 - SCORING: Journal article

C2 - 34302190

VL - 110

SP - 1939

EP - 1946

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 12

ER -