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Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease

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Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. / Hua, Xiaoqin; Deuse, Tobias; Tang-Quan, Karis R; Robbins, Robert C; Reichenspurner, Hermann; Schrepfer, Sonja.

In: JOVE-J VIS EXP, No. 35, 20.01.2010, p. 1437.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hua, X, Deuse, T, Tang-Quan, KR, Robbins, RC, Reichenspurner, H & Schrepfer, S 2010, 'Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease', JOVE-J VIS EXP, no. 35, pp. 1437. https://doi.org/10.3791/1437

APA

Hua, X., Deuse, T., Tang-Quan, K. R., Robbins, R. C., Reichenspurner, H., & Schrepfer, S. (2010). Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. JOVE-J VIS EXP, (35), 1437. https://doi.org/10.3791/1437

Vancouver

Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. JOVE-J VIS EXP. 2010 Jan 20;(35):1437. https://doi.org/10.3791/1437

Bibtex

@article{4d4bfcd65f744a29aa8ec1a5d8e3b07c,
title = "Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease",
abstract = "Obliterative airway disease (OAD) is the major complication after lung transplantations that limits long term survival (1-7). To study the pathophysiology, treatment and prevention of OAD, different animal models of tracheal transplantation in rodents have been developed (1-7). Here, we use two established models of trachea transplantation, the heterotopic and orthotopic model and demonstrate their advantages and limitations. For the heterotopic model, the donor trachea is wrapped into the greater omentum of the recipient, whereas the donor trachea is anastomosed by end-to-end anastomosis in the orthotopic model. In both models, the development of obliterative lesions histological similar to clinical OAD has been demonstrated (1-7). This video shows how to perform both, the heterotopic as well as the orthotopic tracheal transplantation technique in mice, and compares the time course of OAD development in both models using histology.",
keywords = "Airway Obstruction/etiology, Animals, Disease Models, Animal, Mice, Trachea/transplantation, Transplantation/adverse effects",
author = "Xiaoqin Hua and Tobias Deuse and Tang-Quan, {Karis R} and Robbins, {Robert C} and Hermann Reichenspurner and Sonja Schrepfer",
year = "2010",
month = jan,
day = "20",
doi = "10.3791/1437",
language = "English",
pages = "1437",
journal = "JOVE-J VIS EXP",
issn = "1940-087X",
publisher = "MYJoVE Corporation",
number = "35",

}

RIS

TY - JOUR

T1 - Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease

AU - Hua, Xiaoqin

AU - Deuse, Tobias

AU - Tang-Quan, Karis R

AU - Robbins, Robert C

AU - Reichenspurner, Hermann

AU - Schrepfer, Sonja

PY - 2010/1/20

Y1 - 2010/1/20

N2 - Obliterative airway disease (OAD) is the major complication after lung transplantations that limits long term survival (1-7). To study the pathophysiology, treatment and prevention of OAD, different animal models of tracheal transplantation in rodents have been developed (1-7). Here, we use two established models of trachea transplantation, the heterotopic and orthotopic model and demonstrate their advantages and limitations. For the heterotopic model, the donor trachea is wrapped into the greater omentum of the recipient, whereas the donor trachea is anastomosed by end-to-end anastomosis in the orthotopic model. In both models, the development of obliterative lesions histological similar to clinical OAD has been demonstrated (1-7). This video shows how to perform both, the heterotopic as well as the orthotopic tracheal transplantation technique in mice, and compares the time course of OAD development in both models using histology.

AB - Obliterative airway disease (OAD) is the major complication after lung transplantations that limits long term survival (1-7). To study the pathophysiology, treatment and prevention of OAD, different animal models of tracheal transplantation in rodents have been developed (1-7). Here, we use two established models of trachea transplantation, the heterotopic and orthotopic model and demonstrate their advantages and limitations. For the heterotopic model, the donor trachea is wrapped into the greater omentum of the recipient, whereas the donor trachea is anastomosed by end-to-end anastomosis in the orthotopic model. In both models, the development of obliterative lesions histological similar to clinical OAD has been demonstrated (1-7). This video shows how to perform both, the heterotopic as well as the orthotopic tracheal transplantation technique in mice, and compares the time course of OAD development in both models using histology.

KW - Airway Obstruction/etiology

KW - Animals

KW - Disease Models, Animal

KW - Mice

KW - Trachea/transplantation

KW - Transplantation/adverse effects

U2 - 10.3791/1437

DO - 10.3791/1437

M3 - SCORING: Journal article

C2 - 20090665

SP - 1437

JO - JOVE-J VIS EXP

JF - JOVE-J VIS EXP

SN - 1940-087X

IS - 35

ER -