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Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging

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Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. / Thaler, Christian; Kyselyova, Anna A; Faizy, Tobias D; Nawka, Marie T; Jespersen, Sune; Hansen, Brian; Stellmann, Jan-Patrick; Heesen, Christoph; Stürner, Klarissa H; Stark, Maria; Fiehler, Jens; Bester, Maxim; Gellißen, Susanne.

In: PLOS ONE, Vol. 16, No. 2, e0245844, 04.02.2021.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Thaler, C, Kyselyova, AA, Faizy, TD, Nawka, MT, Jespersen, S, Hansen, B, Stellmann, J-P, Heesen, C, Stürner, KH, Stark, M, Fiehler, J, Bester, M & Gellißen, S 2021, 'Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging', PLOS ONE, vol. 16, no. 2, e0245844. https://doi.org/10.1371/journal.pone.0245844

APA

Thaler, C., Kyselyova, A. A., Faizy, T. D., Nawka, M. T., Jespersen, S., Hansen, B., Stellmann, J-P., Heesen, C., Stürner, K. H., Stark, M., Fiehler, J., Bester, M., & Gellißen, S. (2021). Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. PLOS ONE, 16(2), [e0245844]. https://doi.org/10.1371/journal.pone.0245844

Vancouver

Thaler C, Kyselyova AA, Faizy TD, Nawka MT, Jespersen S, Hansen B et al. Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging. PLOS ONE. 2021 Feb 4;16(2). e0245844. https://doi.org/10.1371/journal.pone.0245844

Bibtex

@article{ad096fff520148db9e084876084da352,
title = "Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging",
abstract = "BACKGROUND: Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.METHODS: Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH).RESULTS: Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not.CONCLUSION: MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.",
keywords = "Adolescent, Adult, Cohort Studies, Diffusion Tensor Imaging, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Multiple Sclerosis/diagnostic imaging, White Matter/diagnostic imaging, Young Adult",
author = "Christian Thaler and Kyselyova, {Anna A} and Faizy, {Tobias D} and Nawka, {Marie T} and Sune Jespersen and Brian Hansen and Jan-Patrick Stellmann and Christoph Heesen and St{\"u}rner, {Klarissa H} and Maria Stark and Jens Fiehler and Maxim Bester and Susanne Gelli{\ss}en",
year = "2021",
month = feb,
day = "4",
doi = "10.1371/journal.pone.0245844",
language = "English",
volume = "16",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

RIS

TY - JOUR

T1 - Heterogeneity of multiple sclerosis lesions in fast diffusional kurtosis imaging

AU - Thaler, Christian

AU - Kyselyova, Anna A

AU - Faizy, Tobias D

AU - Nawka, Marie T

AU - Jespersen, Sune

AU - Hansen, Brian

AU - Stellmann, Jan-Patrick

AU - Heesen, Christoph

AU - Stürner, Klarissa H

AU - Stark, Maria

AU - Fiehler, Jens

AU - Bester, Maxim

AU - Gellißen, Susanne

PY - 2021/2/4

Y1 - 2021/2/4

N2 - BACKGROUND: Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.METHODS: Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH).RESULTS: Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not.CONCLUSION: MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.

AB - BACKGROUND: Mean kurtosis (MK), one of the parameters derived from diffusion kurtosis imaging (DKI), has shown increased sensitivity to tissue microstructure damage in several neurological disorders.METHODS: Thirty-seven patients with relapsing-remitting MS and eleven healthy controls (HC) received brain imaging on a 3T MR scanner, including a fast DKI sequence. MK and mean diffusivity (MD) were measured in the white matter of HC, normal-appearing white matter (NAWM) of MS patients, contrast-enhancing lesions (CE-L), FLAIR lesions (FLAIR-L) and black holes (BH).RESULTS: Overall 1529 lesions were analyzed, including 30 CE-L, 832 FLAIR-L and 667 BH. Highest MK values were obtained in the white matter of HC (0.814 ± 0.129), followed by NAWM (0.724 ± 0.137), CE-L (0.619 ± 0.096), FLAIR-L (0.565 ± 0.123) and BH (0.549 ± 0.12). Lowest MD values were obtained in the white matter of HC (0.747 ± 0.068 10-3mm2/sec), followed by NAWM (0.808 ± 0.163 10-3mm2/sec), CE-L (0.853 ± 0.211 10-3mm2/sec), BH (0.957 ± 0.304 10-3mm2/sec) and FLAIR-L (0.976 ± 0.35 10-3mm2/sec). While MK differed significantly between CE-L and non-enhancing lesions, MD did not.CONCLUSION: MK adds predictive value to differentiate between MS lesions and might provide further information about diffuse white matter injury and lesion microstructure.

KW - Adolescent

KW - Adult

KW - Cohort Studies

KW - Diffusion Tensor Imaging

KW - Female

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Male

KW - Middle Aged

KW - Multiple Sclerosis/diagnostic imaging

KW - White Matter/diagnostic imaging

KW - Young Adult

U2 - 10.1371/journal.pone.0245844

DO - 10.1371/journal.pone.0245844

M3 - SCORING: Journal article

C2 - 33539364

VL - 16

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 2

M1 - e0245844

ER -