Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report
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Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report. / Leypoldt, Frank; Titulaer, Maarten J; Aguilar, Esther; Walther, Janine; Bönstrup, Marlene; Havemeister, Stefanie; Teegen, Bianca; Lütgehetmann, Marc; Rosenkranz, Michael; Magnus, Tim; Dalmau, Josep.
In: NEUROLOGY, Vol. 81, No. 18, 29.10.2013, p. 1637-9.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report
AU - Leypoldt, Frank
AU - Titulaer, Maarten J
AU - Aguilar, Esther
AU - Walther, Janine
AU - Bönstrup, Marlene
AU - Havemeister, Stefanie
AU - Teegen, Bianca
AU - Lütgehetmann, Marc
AU - Rosenkranz, Michael
AU - Magnus, Tim
AU - Dalmau, Josep
PY - 2013/10/29
Y1 - 2013/10/29
N2 - Relapsing symptoms post herpes simplex virus 1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) a true viral relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, and response to acyclovir therapy) or 2) a disorder postulated to be immune-mediated (CSF negative for HSV, no new necrotic lesions, and no response to acyclovir).(1,2) It has been suggested that this immune-mediated disorder may be related to NMDA receptor (NMDAR) antibodies,(3) and we recently reported a child in whom relapsing symptoms post HSVE were the presentation of anti-NMDAR encephalitis.(4) We report an adult with this disorder, demonstrate that synthesis of NMDAR antibodies began after HSVE, and show that relapsing symptoms were due to steroid-responsive anti-NMDAR encephalitis.
AB - Relapsing symptoms post herpes simplex virus 1 (HSV) encephalitis (HSVE) usually occur a few weeks after viral therapy and represent either 1) a true viral relapse of HSVE (CSF PCR positive for HSV, new necrotic lesions on brain MRI, and response to acyclovir therapy) or 2) a disorder postulated to be immune-mediated (CSF negative for HSV, no new necrotic lesions, and no response to acyclovir).(1,2) It has been suggested that this immune-mediated disorder may be related to NMDA receptor (NMDAR) antibodies,(3) and we recently reported a child in whom relapsing symptoms post HSVE were the presentation of anti-NMDAR encephalitis.(4) We report an adult with this disorder, demonstrate that synthesis of NMDAR antibodies began after HSVE, and show that relapsing symptoms were due to steroid-responsive anti-NMDAR encephalitis.
KW - Anti-N-Methyl-D-Aspartate Receptor Encephalitis
KW - Encephalitis, Viral
KW - Herpesvirus 1, Human
KW - Humans
KW - Male
KW - Young Adult
U2 - 10.1212/WNL.0b013e3182a9f531
DO - 10.1212/WNL.0b013e3182a9f531
M3 - SCORING: Journal article
C2 - 24089390
VL - 81
SP - 1637
EP - 1639
JO - NEUROLOGY
JF - NEUROLOGY
SN - 0028-3878
IS - 18
ER -