HER2-positives und metastasiertes Mammakarzinom: Standards und neue Entwicklungen
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HER2-positives und metastasiertes Mammakarzinom: Standards und neue Entwicklungen. / Fehm, Tanja; Müller, Volkmar.
In: ONKOLOGE, Vol. 26, No. 6, 01.06.2020, p. 518-523.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - HER2-positives und metastasiertes Mammakarzinom: Standards und neue Entwicklungen
AU - Fehm, Tanja
AU - Müller, Volkmar
N1 - Publisher Copyright: © 2020, Springer Medizin Verlag GmbH, ein Teil von Springer Nature. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - With the development of the monoclonal antibody trastuzumab against HER2, a significant breakthrough was achieved in the treatment of metastatic HER2-positive breast cancer. In the years that followed, dual blockade with the antibodies trastuzumab and pertuzumab in combination with taxane-containing chemotherapy resulted in a further significant improvement in both the metastatic and adjuvant treatment situation. The relevant literature was evaluated. T‑DM1, which is an antibody–drug conjugate comprising trastuzumab and mertansine, has further increased survival in the metastatic situation after trastuzumab compared to the former second-line treatment standard capecitabine/lapatinib. New drug developments include tyrosine kinase inhibitors such as neratinib and tucatenib as well as innovative antibody–drug conjugates including trastuzumab–deruxtecane. As various new substances are currently being evaluated, patients should be included in treatment studies whenever possible.
AB - With the development of the monoclonal antibody trastuzumab against HER2, a significant breakthrough was achieved in the treatment of metastatic HER2-positive breast cancer. In the years that followed, dual blockade with the antibodies trastuzumab and pertuzumab in combination with taxane-containing chemotherapy resulted in a further significant improvement in both the metastatic and adjuvant treatment situation. The relevant literature was evaluated. T‑DM1, which is an antibody–drug conjugate comprising trastuzumab and mertansine, has further increased survival in the metastatic situation after trastuzumab compared to the former second-line treatment standard capecitabine/lapatinib. New drug developments include tyrosine kinase inhibitors such as neratinib and tucatenib as well as innovative antibody–drug conjugates including trastuzumab–deruxtecane. As various new substances are currently being evaluated, patients should be included in treatment studies whenever possible.
KW - Antibodies, monoclonal, humanized
KW - Molecular targeted therapy
KW - Protein-tyrosine kinases
KW - Receptor ErbB‑2
KW - Trastuzumab
UR - http://www.scopus.com/inward/record.url?scp=85079607709&partnerID=8YFLogxK
U2 - 10.1007/s00761-020-00724-7
DO - 10.1007/s00761-020-00724-7
M3 - SCORING: Review
AN - SCOPUS:85079607709
VL - 26
SP - 518
EP - 523
JO - ONKOLOGE
JF - ONKOLOGE
SN - 0947-8965
IS - 6
ER -