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Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas

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Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas. / Hanken, Henning; Gaudin, Robert; Gröbe, Alexander; Fraederich, Meike; Eichhorn, Wolfgang; Smeets, Ralf; Simon, Ronald; Sauter, Guido; Grupp, Katharina; Izbicki, Jakob; Sehner, Susanne; Heiland, Max; Blessmann, Marco.

In: J ORAL PATHOL MED, Vol. 43, No. 4, 01.04.2014, p. 304-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hanken, H, Gaudin, R, Gröbe, A, Fraederich, M, Eichhorn, W, Smeets, R, Simon, R, Sauter, G, Grupp, K, Izbicki, J, Sehner, S, Heiland, M & Blessmann, M 2014, 'Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas', J ORAL PATHOL MED, vol. 43, no. 4, pp. 304-8. https://doi.org/10.1111/jop.12173

APA

Hanken, H., Gaudin, R., Gröbe, A., Fraederich, M., Eichhorn, W., Smeets, R., Simon, R., Sauter, G., Grupp, K., Izbicki, J., Sehner, S., Heiland, M., & Blessmann, M. (2014). Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas. J ORAL PATHOL MED, 43(4), 304-8. https://doi.org/10.1111/jop.12173

Vancouver

Hanken H, Gaudin R, Gröbe A, Fraederich M, Eichhorn W, Smeets R et al. Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas. J ORAL PATHOL MED. 2014 Apr 1;43(4):304-8. https://doi.org/10.1111/jop.12173

Bibtex

@article{ca957e73f4454e38940f77cf31504ce4,
title = "Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas",
abstract = "PURPOSE: Her2 (ErbB2) transforms cells when overexpressed and is an important therapeutic target in breast cancer. Contrary to breast cancer, studies on Her2 overexpression and gene amplification in squamous cell carcinomas of the head and neck region described largely different results. This study was undertaken to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in squamous cell carcinomas of the head and neck.MATERIALS AND METHODS: Her2 expression and gene amplification was analyzed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on two tissue microarrays composed of 427 squamous cell carcinomas of the head and neck region and 222 oral squamous cell carcinomas. Results were compared with clinicopathological features.RESULTS: Her2 expression and gene amplification was rarely detectable in squamous cell carcinomas of the head and neck region and unrelated to tumor phenotype or survival of the patients with oral squamous carcinoma.DISCUSSION: Our results demonstrate that Her2 protein and gene amplification was only detectable in a small subset of squamous cell carcinomas of the head and neck region as well as oral squamous cell carcinomas. However, it can be speculated that those few patients with Her2 overexpressing and gene amplificated tumors may possibly benefit from an anti-Her2 therapy.",
author = "Henning Hanken and Robert Gaudin and Alexander Gr{\"o}be and Meike Fraederich and Wolfgang Eichhorn and Ralf Smeets and Ronald Simon and Guido Sauter and Katharina Grupp and Jakob Izbicki and Susanne Sehner and Max Heiland and Marco Blessmann",
note = "Gaudin INTERN",
year = "2014",
month = apr,
day = "1",
doi = "10.1111/jop.12173",
language = "English",
volume = "43",
pages = "304--8",
journal = "J ORAL PATHOL MED",
issn = "0904-2512",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Her2 expression and gene amplification is rarely detectable in patients with oral squamous cell carcinomas

AU - Hanken, Henning

AU - Gaudin, Robert

AU - Gröbe, Alexander

AU - Fraederich, Meike

AU - Eichhorn, Wolfgang

AU - Smeets, Ralf

AU - Simon, Ronald

AU - Sauter, Guido

AU - Grupp, Katharina

AU - Izbicki, Jakob

AU - Sehner, Susanne

AU - Heiland, Max

AU - Blessmann, Marco

N1 - Gaudin INTERN

PY - 2014/4/1

Y1 - 2014/4/1

N2 - PURPOSE: Her2 (ErbB2) transforms cells when overexpressed and is an important therapeutic target in breast cancer. Contrary to breast cancer, studies on Her2 overexpression and gene amplification in squamous cell carcinomas of the head and neck region described largely different results. This study was undertaken to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in squamous cell carcinomas of the head and neck.MATERIALS AND METHODS: Her2 expression and gene amplification was analyzed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on two tissue microarrays composed of 427 squamous cell carcinomas of the head and neck region and 222 oral squamous cell carcinomas. Results were compared with clinicopathological features.RESULTS: Her2 expression and gene amplification was rarely detectable in squamous cell carcinomas of the head and neck region and unrelated to tumor phenotype or survival of the patients with oral squamous carcinoma.DISCUSSION: Our results demonstrate that Her2 protein and gene amplification was only detectable in a small subset of squamous cell carcinomas of the head and neck region as well as oral squamous cell carcinomas. However, it can be speculated that those few patients with Her2 overexpressing and gene amplificated tumors may possibly benefit from an anti-Her2 therapy.

AB - PURPOSE: Her2 (ErbB2) transforms cells when overexpressed and is an important therapeutic target in breast cancer. Contrary to breast cancer, studies on Her2 overexpression and gene amplification in squamous cell carcinomas of the head and neck region described largely different results. This study was undertaken to learn more on the prevalence and clinical significance of HER2 amplification and overexpression in squamous cell carcinomas of the head and neck.MATERIALS AND METHODS: Her2 expression and gene amplification was analyzed by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) on two tissue microarrays composed of 427 squamous cell carcinomas of the head and neck region and 222 oral squamous cell carcinomas. Results were compared with clinicopathological features.RESULTS: Her2 expression and gene amplification was rarely detectable in squamous cell carcinomas of the head and neck region and unrelated to tumor phenotype or survival of the patients with oral squamous carcinoma.DISCUSSION: Our results demonstrate that Her2 protein and gene amplification was only detectable in a small subset of squamous cell carcinomas of the head and neck region as well as oral squamous cell carcinomas. However, it can be speculated that those few patients with Her2 overexpressing and gene amplificated tumors may possibly benefit from an anti-Her2 therapy.

U2 - 10.1111/jop.12173

DO - 10.1111/jop.12173

M3 - SCORING: Journal article

C2 - 24645976

VL - 43

SP - 304

EP - 308

JO - J ORAL PATHOL MED

JF - J ORAL PATHOL MED

SN - 0904-2512

IS - 4

ER -