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Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon

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Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon. / Feldt, Torsten; Sarfo, Fred Stephen; Zoufaly, Alexander; Phillips, Richard Odame; Burchard, Gerd-Dieter; van Lunzen, Jan; Jochum, Johannes; Chadwick, David; Awasom, Charles; Claussen, Lisa; Drosten, Christian; Drexler, Jan Felix; Eis-Hübinger, Anna Maria.

In: J CLIN VIROL, Vol. 58, No. 1, 01.09.2013, p. 18-23.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Feldt, T, Sarfo, FS, Zoufaly, A, Phillips, RO, Burchard, G-D, van Lunzen, J, Jochum, J, Chadwick, D, Awasom, C, Claussen, L, Drosten, C, Drexler, JF & Eis-Hübinger, AM 2013, 'Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon', J CLIN VIROL, vol. 58, no. 1, pp. 18-23. https://doi.org/10.1016/j.jcv.2013.05.004

APA

Feldt, T., Sarfo, F. S., Zoufaly, A., Phillips, R. O., Burchard, G-D., van Lunzen, J., Jochum, J., Chadwick, D., Awasom, C., Claussen, L., Drosten, C., Drexler, J. F., & Eis-Hübinger, A. M. (2013). Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon. J CLIN VIROL, 58(1), 18-23. https://doi.org/10.1016/j.jcv.2013.05.004

Vancouver

Feldt T, Sarfo FS, Zoufaly A, Phillips RO, Burchard G-D, van Lunzen J et al. Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon. J CLIN VIROL. 2013 Sep 1;58(1):18-23. https://doi.org/10.1016/j.jcv.2013.05.004

Bibtex

@article{3b15079c5c7b49a2a10ac8f8f6a68558,
title = "Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon",
abstract = "BACKGROUND: Chronic hepatitis E virus (HEV) infections have recently been described in HIV-infected patients. Only few data are available for sub-Saharan Africa, where HIV and HEV are highly co-endemic, and where liver pathology is common in HIV-infected individuals.OBJECTIVES: To assess the prevalence of HEV viremia, anti-HEV antibodies, and serum aminotransferase levels in HIV patients in Ghana and Cameroon.STUDY DESIGN: We retrospectively surveyed a cross-section of patients who were enrolled in cohort studies in Ghana (West Africa), and Cameroon (Central Africa). Plasma samples from 1029 HIV patients from Ghana and 515 patients from Cameroon including 214 children were analyzed for HEV-RNA by two reverse transcription PCR methods. In a subset of 791 patients, anti-HEV IgG and IgM antibodies were analyzed.RESULTS: No HEV-RNA was detected in any of the plasma samples of 1544 patients. HEV seroprevalence was high in adult HIV patients from Ghana (45.3%, n=402) and Cameroon (14.2%, n=289), but low in pediatric HIV patients from Cameroon (2.0%, n=100). Elevations of alanine aminotransferase and aspartate aminotransferase levels were common in adult patients from Ghana (20.8% and 25.4%) and Cameroon (38.9% and 69.8%). The prevalence of hepatitis B virus surface antigen was 11.8% and of hepatitis C virus antibodies 2.5% in our adult Cameroonian study population.CONCLUSIONS: Acute or chronic HEV infections did not play a role in liver pathology in two HIV cohorts in Ghana and Cameroon. A better understanding of the epidemiology and genotype-specific characteristics of HEV infections in HIV patients in sub-Saharan Africa is needed.",
keywords = "Adolescent, Adult, Cameroon, Child, Child, Preschool, Cohort Studies, Coinfection, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, Ghana, HIV Infections, Hepatitis Antibodies, Hepatitis E, Hepatitis E virus, Humans, Immunoglobulin G, Immunoglobulin M, Infant, Male, Middle Aged, Prevalence, RNA, Viral, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Transaminases",
author = "Torsten Feldt and Sarfo, {Fred Stephen} and Alexander Zoufaly and Phillips, {Richard Odame} and Gerd-Dieter Burchard and {van Lunzen}, Jan and Johannes Jochum and David Chadwick and Charles Awasom and Lisa Claussen and Christian Drosten and Drexler, {Jan Felix} and Eis-H{\"u}binger, {Anna Maria}",
note = "Copyright {\textcopyright} 2013 Elsevier B.V. All rights reserved.",
year = "2013",
month = sep,
day = "1",
doi = "10.1016/j.jcv.2013.05.004",
language = "English",
volume = "58",
pages = "18--23",
journal = "J CLIN VIROL",
issn = "1386-6532",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon

AU - Feldt, Torsten

AU - Sarfo, Fred Stephen

AU - Zoufaly, Alexander

AU - Phillips, Richard Odame

AU - Burchard, Gerd-Dieter

AU - van Lunzen, Jan

AU - Jochum, Johannes

AU - Chadwick, David

AU - Awasom, Charles

AU - Claussen, Lisa

AU - Drosten, Christian

AU - Drexler, Jan Felix

AU - Eis-Hübinger, Anna Maria

N1 - Copyright © 2013 Elsevier B.V. All rights reserved.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - BACKGROUND: Chronic hepatitis E virus (HEV) infections have recently been described in HIV-infected patients. Only few data are available for sub-Saharan Africa, where HIV and HEV are highly co-endemic, and where liver pathology is common in HIV-infected individuals.OBJECTIVES: To assess the prevalence of HEV viremia, anti-HEV antibodies, and serum aminotransferase levels in HIV patients in Ghana and Cameroon.STUDY DESIGN: We retrospectively surveyed a cross-section of patients who were enrolled in cohort studies in Ghana (West Africa), and Cameroon (Central Africa). Plasma samples from 1029 HIV patients from Ghana and 515 patients from Cameroon including 214 children were analyzed for HEV-RNA by two reverse transcription PCR methods. In a subset of 791 patients, anti-HEV IgG and IgM antibodies were analyzed.RESULTS: No HEV-RNA was detected in any of the plasma samples of 1544 patients. HEV seroprevalence was high in adult HIV patients from Ghana (45.3%, n=402) and Cameroon (14.2%, n=289), but low in pediatric HIV patients from Cameroon (2.0%, n=100). Elevations of alanine aminotransferase and aspartate aminotransferase levels were common in adult patients from Ghana (20.8% and 25.4%) and Cameroon (38.9% and 69.8%). The prevalence of hepatitis B virus surface antigen was 11.8% and of hepatitis C virus antibodies 2.5% in our adult Cameroonian study population.CONCLUSIONS: Acute or chronic HEV infections did not play a role in liver pathology in two HIV cohorts in Ghana and Cameroon. A better understanding of the epidemiology and genotype-specific characteristics of HEV infections in HIV patients in sub-Saharan Africa is needed.

AB - BACKGROUND: Chronic hepatitis E virus (HEV) infections have recently been described in HIV-infected patients. Only few data are available for sub-Saharan Africa, where HIV and HEV are highly co-endemic, and where liver pathology is common in HIV-infected individuals.OBJECTIVES: To assess the prevalence of HEV viremia, anti-HEV antibodies, and serum aminotransferase levels in HIV patients in Ghana and Cameroon.STUDY DESIGN: We retrospectively surveyed a cross-section of patients who were enrolled in cohort studies in Ghana (West Africa), and Cameroon (Central Africa). Plasma samples from 1029 HIV patients from Ghana and 515 patients from Cameroon including 214 children were analyzed for HEV-RNA by two reverse transcription PCR methods. In a subset of 791 patients, anti-HEV IgG and IgM antibodies were analyzed.RESULTS: No HEV-RNA was detected in any of the plasma samples of 1544 patients. HEV seroprevalence was high in adult HIV patients from Ghana (45.3%, n=402) and Cameroon (14.2%, n=289), but low in pediatric HIV patients from Cameroon (2.0%, n=100). Elevations of alanine aminotransferase and aspartate aminotransferase levels were common in adult patients from Ghana (20.8% and 25.4%) and Cameroon (38.9% and 69.8%). The prevalence of hepatitis B virus surface antigen was 11.8% and of hepatitis C virus antibodies 2.5% in our adult Cameroonian study population.CONCLUSIONS: Acute or chronic HEV infections did not play a role in liver pathology in two HIV cohorts in Ghana and Cameroon. A better understanding of the epidemiology and genotype-specific characteristics of HEV infections in HIV patients in sub-Saharan Africa is needed.

KW - Adolescent

KW - Adult

KW - Cameroon

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Coinfection

KW - Cross-Sectional Studies

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Ghana

KW - HIV Infections

KW - Hepatitis Antibodies

KW - Hepatitis E

KW - Hepatitis E virus

KW - Humans

KW - Immunoglobulin G

KW - Immunoglobulin M

KW - Infant

KW - Male

KW - Middle Aged

KW - Prevalence

KW - RNA, Viral

KW - Retrospective Studies

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Transaminases

U2 - 10.1016/j.jcv.2013.05.004

DO - 10.1016/j.jcv.2013.05.004

M3 - SCORING: Journal article

C2 - 23743346

VL - 58

SP - 18

EP - 23

JO - J CLIN VIROL

JF - J CLIN VIROL

SN - 1386-6532

IS - 1

ER -