Hepatitis E: Still Waters Run Deep
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Hepatitis E: Still Waters Run Deep. / von Wulffen, Moritz; Westhölter, Dirk; Lütgehetmann, Marc; Pischke, Sven.
In: J CLIN TRANSL HEPATO, Vol. 6, No. 1, 28.03.2018, p. 40-47.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Hepatitis E: Still Waters Run Deep
AU - von Wulffen, Moritz
AU - Westhölter, Dirk
AU - Lütgehetmann, Marc
AU - Pischke, Sven
PY - 2018/3/28
Y1 - 2018/3/28
N2 - Hepatitis E is an infectious inflammatory disease of the liver caused by the hepatitis E virus (HEV), a single-stranded RNA virus. Today, it is estimated that there are more than 20 million HEV infections every year, leading to 3.3 million symptomatic cases and more than 56,000 deaths. For a long time it was believed that HEV was a travel-associated disease, endemic in developing countries with poor hygienic standards and unsafe water supply. However, over the past years, publications have demonstrated that autochthonous HEV infections in industrialized countries are far more common than previously thought. Awareness for HEV amongst health care practitioners in industrialized countries is still limited. This relatively rare disease is of great importance, especially in immunocompromised patients where it can cause chronic liver disease. This article comprehensively reviews current literature to give an overview on clinically important topics. It will focus on epidemiological aspects, acute and chronic HEV infection as well as extra-hepatic manifestations, diagnostic approach and treatment options. Furthermore, the article is concluded with a brief outlook on perspectives and urgent problems to be addressed in the future.
AB - Hepatitis E is an infectious inflammatory disease of the liver caused by the hepatitis E virus (HEV), a single-stranded RNA virus. Today, it is estimated that there are more than 20 million HEV infections every year, leading to 3.3 million symptomatic cases and more than 56,000 deaths. For a long time it was believed that HEV was a travel-associated disease, endemic in developing countries with poor hygienic standards and unsafe water supply. However, over the past years, publications have demonstrated that autochthonous HEV infections in industrialized countries are far more common than previously thought. Awareness for HEV amongst health care practitioners in industrialized countries is still limited. This relatively rare disease is of great importance, especially in immunocompromised patients where it can cause chronic liver disease. This article comprehensively reviews current literature to give an overview on clinically important topics. It will focus on epidemiological aspects, acute and chronic HEV infection as well as extra-hepatic manifestations, diagnostic approach and treatment options. Furthermore, the article is concluded with a brief outlook on perspectives and urgent problems to be addressed in the future.
KW - Journal Article
KW - Review
U2 - 10.14218/JCTH.2017.00030
DO - 10.14218/JCTH.2017.00030
M3 - SCORING: Review article
C2 - 29577031
VL - 6
SP - 40
EP - 47
JO - J CLIN TRANSL HEPATO
JF - J CLIN TRANSL HEPATO
SN - 2225-0719
IS - 1
ER -