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Hemoglobin C and resistance to severe malaria in Ghanaian children.

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Hemoglobin C and resistance to severe malaria in Ghanaian children. / Mockenhaupt, Frank P; Ehrhardt, Stephan; Cramer, Jakob; Otchwemah, Rowland N; Anemana, Sylvester D; Goltz, Katharina; Mylius, Franziska; Dietz, Ekkehart; Eggelte, Teunis A; Bienzle, Ulrich.

In: J INFECT DIS, Vol. 190, No. 5, 5, 2004, p. 1006-1009.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mockenhaupt, FP, Ehrhardt, S, Cramer, J, Otchwemah, RN, Anemana, SD, Goltz, K, Mylius, F, Dietz, E, Eggelte, TA & Bienzle, U 2004, 'Hemoglobin C and resistance to severe malaria in Ghanaian children.', J INFECT DIS, vol. 190, no. 5, 5, pp. 1006-1009. <http://www.ncbi.nlm.nih.gov/pubmed/15295709?dopt=Citation>

APA

Mockenhaupt, F. P., Ehrhardt, S., Cramer, J., Otchwemah, R. N., Anemana, S. D., Goltz, K., Mylius, F., Dietz, E., Eggelte, T. A., & Bienzle, U. (2004). Hemoglobin C and resistance to severe malaria in Ghanaian children. J INFECT DIS, 190(5), 1006-1009. [5]. http://www.ncbi.nlm.nih.gov/pubmed/15295709?dopt=Citation

Vancouver

Mockenhaupt FP, Ehrhardt S, Cramer J, Otchwemah RN, Anemana SD, Goltz K et al. Hemoglobin C and resistance to severe malaria in Ghanaian children. J INFECT DIS. 2004;190(5):1006-1009. 5.

Bibtex

@article{074d737515a14ff99233e59cac8ee398,
title = "Hemoglobin C and resistance to severe malaria in Ghanaian children.",
abstract = "Hemoglobin (Hb) C has been reported to protect against severe malaria. It is unclear whether relative resistance affects infection, disease, or both. Its extent may vary between regions and with disease pattern. We conducted a case-control study of children with severe malaria, asymptomatic parasitemic children, and healthy children in Ghana. HbAC did not prevent infection but reduced the odds of developing severe malaria and severe anemia. Protection was stronger with HbAS. The frequencies of HbCC and HbSC decreased, from healthy children to asymptomatic parasitemic children to children with severe malaria. These data support the notion that natural selection of HbC occurs because of the relative resistance it confers against severe malaria but argue against the notion that HbC offers resistance to infection.",
author = "Mockenhaupt, {Frank P} and Stephan Ehrhardt and Jakob Cramer and Otchwemah, {Rowland N} and Anemana, {Sylvester D} and Katharina Goltz and Franziska Mylius and Ekkehart Dietz and Eggelte, {Teunis A} and Ulrich Bienzle",
year = "2004",
language = "Deutsch",
volume = "190",
pages = "1006--1009",
journal = "J INFECT DIS",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",

}

RIS

TY - JOUR

T1 - Hemoglobin C and resistance to severe malaria in Ghanaian children.

AU - Mockenhaupt, Frank P

AU - Ehrhardt, Stephan

AU - Cramer, Jakob

AU - Otchwemah, Rowland N

AU - Anemana, Sylvester D

AU - Goltz, Katharina

AU - Mylius, Franziska

AU - Dietz, Ekkehart

AU - Eggelte, Teunis A

AU - Bienzle, Ulrich

PY - 2004

Y1 - 2004

N2 - Hemoglobin (Hb) C has been reported to protect against severe malaria. It is unclear whether relative resistance affects infection, disease, or both. Its extent may vary between regions and with disease pattern. We conducted a case-control study of children with severe malaria, asymptomatic parasitemic children, and healthy children in Ghana. HbAC did not prevent infection but reduced the odds of developing severe malaria and severe anemia. Protection was stronger with HbAS. The frequencies of HbCC and HbSC decreased, from healthy children to asymptomatic parasitemic children to children with severe malaria. These data support the notion that natural selection of HbC occurs because of the relative resistance it confers against severe malaria but argue against the notion that HbC offers resistance to infection.

AB - Hemoglobin (Hb) C has been reported to protect against severe malaria. It is unclear whether relative resistance affects infection, disease, or both. Its extent may vary between regions and with disease pattern. We conducted a case-control study of children with severe malaria, asymptomatic parasitemic children, and healthy children in Ghana. HbAC did not prevent infection but reduced the odds of developing severe malaria and severe anemia. Protection was stronger with HbAS. The frequencies of HbCC and HbSC decreased, from healthy children to asymptomatic parasitemic children to children with severe malaria. These data support the notion that natural selection of HbC occurs because of the relative resistance it confers against severe malaria but argue against the notion that HbC offers resistance to infection.

M3 - SCORING: Zeitschriftenaufsatz

VL - 190

SP - 1006

EP - 1009

JO - J INFECT DIS

JF - J INFECT DIS

SN - 0022-1899

IS - 5

M1 - 5

ER -