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Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy

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Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy. / Schmidt, Sarah; Fortmeier, Vera; Ludwig, Sebastian; Wienemann, Hendrik; Körber, Maria Isabel; Lee, Samuel; Meertens, Max; Macherey, Sascha; Iliadis, Christos; Kuhn, Elmar; Eghbalzadeh, Kaveh; Bleiziffer, Sabine; Baldus, Stephan; Schofer, Niklas; Rudolph, Tanja Katharina; Adam, Matti; Mauri, Victor.

In: CLIN RES CARDIOL, Vol. 111, No. 12, 12.2022, p. 1336-1347.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schmidt, S, Fortmeier, V, Ludwig, S, Wienemann, H, Körber, MI, Lee, S, Meertens, M, Macherey, S, Iliadis, C, Kuhn, E, Eghbalzadeh, K, Bleiziffer, S, Baldus, S, Schofer, N, Rudolph, TK, Adam, M & Mauri, V 2022, 'Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy', CLIN RES CARDIOL, vol. 111, no. 12, pp. 1336-1347. https://doi.org/10.1007/s00392-022-02046-7

APA

Schmidt, S., Fortmeier, V., Ludwig, S., Wienemann, H., Körber, M. I., Lee, S., Meertens, M., Macherey, S., Iliadis, C., Kuhn, E., Eghbalzadeh, K., Bleiziffer, S., Baldus, S., Schofer, N., Rudolph, T. K., Adam, M., & Mauri, V. (2022). Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy. CLIN RES CARDIOL, 111(12), 1336-1347. https://doi.org/10.1007/s00392-022-02046-7

Vancouver

Schmidt S, Fortmeier V, Ludwig S, Wienemann H, Körber MI, Lee S et al. Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy. CLIN RES CARDIOL. 2022 Dec;111(12):1336-1347. https://doi.org/10.1007/s00392-022-02046-7

Bibtex

@article{884b617035b94c8a90778b079099cdc2,
title = "Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy",
abstract = "OBJECTIVES: This study aimed to compare hemodynamic characteristics of different self-expanding (SE) and balloon-expandable (BE) transcatheter heart valves (THV) in relation to native aortic annulus anatomy.BACKGROUND: A patient centered THV selection becomes increasingly important as indications for transcatheter aortic valve replacement (TAVR) are extended towards lower risk populations.METHODS: Hemodynamic parameters including mean gradient (MG), effective orifice area (EOA), Doppler velocity index (DVI), degree of paravalvular regurgitation (PVR) and patient-prosthesis mismatch (PPM) were compared by valve type, label size and in relation to quintiles of native aortic annulus area.RESULTS: 2609 patients were treated at 3 centers in Germany with SAPIEN 3 (n = 1146), ACURATE Neo (n = 649), Evolut R (n = 546) or Evolut Pro (n = 268) THV. SE THVs provided superior hemodynamics in terms of larger EOA, higher DVI and lower MG compared to BE THV, especially in patients with small aortic annuli. Severe PPM was less frequent in SE treated patients. The rate of PVR ≥ moderate was comparable for SE and BE devices in smaller annular dimensions, but remarkably lower for BE TAVR in large aortic annular dimensions (> 547.64 mm2) (2% BE THV vs. > 10% for SE THV; p < 0.001).CONCLUSIONS: Patients with small aortic annular dimensions may benefit hemodynamically from SE THV. With increasing annulus size, BE THV may have advantages since PVR ≥ moderate occurs less frequently.",
keywords = "Humans, Aortic Valve Stenosis/diagnosis, Heart Valve Prosthesis, Aortic Valve/diagnostic imaging, Prosthesis Design, Treatment Outcome, Time Factors, Transcatheter Aortic Valve Replacement/adverse effects, Hemodynamics",
author = "Sarah Schmidt and Vera Fortmeier and Sebastian Ludwig and Hendrik Wienemann and K{\"o}rber, {Maria Isabel} and Samuel Lee and Max Meertens and Sascha Macherey and Christos Iliadis and Elmar Kuhn and Kaveh Eghbalzadeh and Sabine Bleiziffer and Stephan Baldus and Niklas Schofer and Rudolph, {Tanja Katharina} and Matti Adam and Victor Mauri",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = dec,
doi = "10.1007/s00392-022-02046-7",
language = "English",
volume = "111",
pages = "1336--1347",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "12",

}

RIS

TY - JOUR

T1 - Hemodynamics of self-expanding versus balloon-expandable transcatheter heart valves in relation to native aortic annulus anatomy

AU - Schmidt, Sarah

AU - Fortmeier, Vera

AU - Ludwig, Sebastian

AU - Wienemann, Hendrik

AU - Körber, Maria Isabel

AU - Lee, Samuel

AU - Meertens, Max

AU - Macherey, Sascha

AU - Iliadis, Christos

AU - Kuhn, Elmar

AU - Eghbalzadeh, Kaveh

AU - Bleiziffer, Sabine

AU - Baldus, Stephan

AU - Schofer, Niklas

AU - Rudolph, Tanja Katharina

AU - Adam, Matti

AU - Mauri, Victor

N1 - © 2022. The Author(s).

PY - 2022/12

Y1 - 2022/12

N2 - OBJECTIVES: This study aimed to compare hemodynamic characteristics of different self-expanding (SE) and balloon-expandable (BE) transcatheter heart valves (THV) in relation to native aortic annulus anatomy.BACKGROUND: A patient centered THV selection becomes increasingly important as indications for transcatheter aortic valve replacement (TAVR) are extended towards lower risk populations.METHODS: Hemodynamic parameters including mean gradient (MG), effective orifice area (EOA), Doppler velocity index (DVI), degree of paravalvular regurgitation (PVR) and patient-prosthesis mismatch (PPM) were compared by valve type, label size and in relation to quintiles of native aortic annulus area.RESULTS: 2609 patients were treated at 3 centers in Germany with SAPIEN 3 (n = 1146), ACURATE Neo (n = 649), Evolut R (n = 546) or Evolut Pro (n = 268) THV. SE THVs provided superior hemodynamics in terms of larger EOA, higher DVI and lower MG compared to BE THV, especially in patients with small aortic annuli. Severe PPM was less frequent in SE treated patients. The rate of PVR ≥ moderate was comparable for SE and BE devices in smaller annular dimensions, but remarkably lower for BE TAVR in large aortic annular dimensions (> 547.64 mm2) (2% BE THV vs. > 10% for SE THV; p < 0.001).CONCLUSIONS: Patients with small aortic annular dimensions may benefit hemodynamically from SE THV. With increasing annulus size, BE THV may have advantages since PVR ≥ moderate occurs less frequently.

AB - OBJECTIVES: This study aimed to compare hemodynamic characteristics of different self-expanding (SE) and balloon-expandable (BE) transcatheter heart valves (THV) in relation to native aortic annulus anatomy.BACKGROUND: A patient centered THV selection becomes increasingly important as indications for transcatheter aortic valve replacement (TAVR) are extended towards lower risk populations.METHODS: Hemodynamic parameters including mean gradient (MG), effective orifice area (EOA), Doppler velocity index (DVI), degree of paravalvular regurgitation (PVR) and patient-prosthesis mismatch (PPM) were compared by valve type, label size and in relation to quintiles of native aortic annulus area.RESULTS: 2609 patients were treated at 3 centers in Germany with SAPIEN 3 (n = 1146), ACURATE Neo (n = 649), Evolut R (n = 546) or Evolut Pro (n = 268) THV. SE THVs provided superior hemodynamics in terms of larger EOA, higher DVI and lower MG compared to BE THV, especially in patients with small aortic annuli. Severe PPM was less frequent in SE treated patients. The rate of PVR ≥ moderate was comparable for SE and BE devices in smaller annular dimensions, but remarkably lower for BE TAVR in large aortic annular dimensions (> 547.64 mm2) (2% BE THV vs. > 10% for SE THV; p < 0.001).CONCLUSIONS: Patients with small aortic annular dimensions may benefit hemodynamically from SE THV. With increasing annulus size, BE THV may have advantages since PVR ≥ moderate occurs less frequently.

KW - Humans

KW - Aortic Valve Stenosis/diagnosis

KW - Heart Valve Prosthesis

KW - Aortic Valve/diagnostic imaging

KW - Prosthesis Design

KW - Treatment Outcome

KW - Time Factors

KW - Transcatheter Aortic Valve Replacement/adverse effects

KW - Hemodynamics

U2 - 10.1007/s00392-022-02046-7

DO - 10.1007/s00392-022-02046-7

M3 - SCORING: Journal article

C2 - 35704088

VL - 111

SP - 1336

EP - 1347

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 12

ER -