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Hematogenous dissemination of glioblastoma multiforme

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Hematogenous dissemination of glioblastoma multiforme. / Müller, Carolin; Holtschmidt, Johannes; Auer, Martina; Heitzer, Ellen; Lamszus, Katrin; Schulte, Alexander; Matschke, Jakob; Langer-Freitag, Sabine; Gasch, Christin; Stoupiec, Malgorzata; Mauermann, Oliver; Peine, Sven; Glatzel, Markus; Speicher, Michael R; Geigl, Jochen B; Westphal, Manfred; Pantel, Klaus; Riethdorf, Sabine.

In: SCI TRANSL MED, Vol. 6, No. 247, 30.07.2014, p. 247ra101.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Müller, C, Holtschmidt, J, Auer, M, Heitzer, E, Lamszus, K, Schulte, A, Matschke, J, Langer-Freitag, S, Gasch, C, Stoupiec, M, Mauermann, O, Peine, S, Glatzel, M, Speicher, MR, Geigl, JB, Westphal, M, Pantel, K & Riethdorf, S 2014, 'Hematogenous dissemination of glioblastoma multiforme', SCI TRANSL MED, vol. 6, no. 247, pp. 247ra101. https://doi.org/10.1126/scitranslmed.3009095

APA

Müller, C., Holtschmidt, J., Auer, M., Heitzer, E., Lamszus, K., Schulte, A., Matschke, J., Langer-Freitag, S., Gasch, C., Stoupiec, M., Mauermann, O., Peine, S., Glatzel, M., Speicher, M. R., Geigl, J. B., Westphal, M., Pantel, K., & Riethdorf, S. (2014). Hematogenous dissemination of glioblastoma multiforme. SCI TRANSL MED, 6(247), 247ra101. https://doi.org/10.1126/scitranslmed.3009095

Vancouver

Müller C, Holtschmidt J, Auer M, Heitzer E, Lamszus K, Schulte A et al. Hematogenous dissemination of glioblastoma multiforme. SCI TRANSL MED. 2014 Jul 30;6(247):247ra101. https://doi.org/10.1126/scitranslmed.3009095

Bibtex

@article{d33697a9cf5143d48c829e2cb255d34f,
title = "Hematogenous dissemination of glioblastoma multiforme",
abstract = "Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumor in adults. The dogma that GBM spread is restricted to the brain was challenged by reports on extracranial metastases after organ transplantation from GBM donors. We identified circulating tumor cells (CTCs) in peripheral blood (PB) from 29 of 141 (20.6%) GBM patients by immunostaining of enriched mononuclear cells with antibodies directed against glial fibrillary acidic protein (GFAP). Tumor cell spread was not significantly enhanced by surgical intervention. The tumor nature of GFAP-positive cells was supported by the absence of those cells in healthy volunteers and the presence of tumor-specific aberrations such as EGFR gene amplification and gains and losses in genomic regions of chromosomes 7 and 10. Release of CTCs was associated with EGFR gene amplification, suggesting a growth potential of these cells. We demonstrate that hematogenous GBM spread is an intrinsic feature of GBM biology.",
author = "Carolin M{\"u}ller and Johannes Holtschmidt and Martina Auer and Ellen Heitzer and Katrin Lamszus and Alexander Schulte and Jakob Matschke and Sabine Langer-Freitag and Christin Gasch and Malgorzata Stoupiec and Oliver Mauermann and Sven Peine and Markus Glatzel and Speicher, {Michael R} and Geigl, {Jochen B} and Manfred Westphal and Klaus Pantel and Sabine Riethdorf",
note = "Copyright {\textcopyright} 2014, American Association for the Advancement of Science.",
year = "2014",
month = jul,
day = "30",
doi = "10.1126/scitranslmed.3009095",
language = "English",
volume = "6",
pages = "247ra101",
journal = "SCI TRANSL MED",
issn = "1946-6234",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "247",

}

RIS

TY - JOUR

T1 - Hematogenous dissemination of glioblastoma multiforme

AU - Müller, Carolin

AU - Holtschmidt, Johannes

AU - Auer, Martina

AU - Heitzer, Ellen

AU - Lamszus, Katrin

AU - Schulte, Alexander

AU - Matschke, Jakob

AU - Langer-Freitag, Sabine

AU - Gasch, Christin

AU - Stoupiec, Malgorzata

AU - Mauermann, Oliver

AU - Peine, Sven

AU - Glatzel, Markus

AU - Speicher, Michael R

AU - Geigl, Jochen B

AU - Westphal, Manfred

AU - Pantel, Klaus

AU - Riethdorf, Sabine

N1 - Copyright © 2014, American Association for the Advancement of Science.

PY - 2014/7/30

Y1 - 2014/7/30

N2 - Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumor in adults. The dogma that GBM spread is restricted to the brain was challenged by reports on extracranial metastases after organ transplantation from GBM donors. We identified circulating tumor cells (CTCs) in peripheral blood (PB) from 29 of 141 (20.6%) GBM patients by immunostaining of enriched mononuclear cells with antibodies directed against glial fibrillary acidic protein (GFAP). Tumor cell spread was not significantly enhanced by surgical intervention. The tumor nature of GFAP-positive cells was supported by the absence of those cells in healthy volunteers and the presence of tumor-specific aberrations such as EGFR gene amplification and gains and losses in genomic regions of chromosomes 7 and 10. Release of CTCs was associated with EGFR gene amplification, suggesting a growth potential of these cells. We demonstrate that hematogenous GBM spread is an intrinsic feature of GBM biology.

AB - Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumor in adults. The dogma that GBM spread is restricted to the brain was challenged by reports on extracranial metastases after organ transplantation from GBM donors. We identified circulating tumor cells (CTCs) in peripheral blood (PB) from 29 of 141 (20.6%) GBM patients by immunostaining of enriched mononuclear cells with antibodies directed against glial fibrillary acidic protein (GFAP). Tumor cell spread was not significantly enhanced by surgical intervention. The tumor nature of GFAP-positive cells was supported by the absence of those cells in healthy volunteers and the presence of tumor-specific aberrations such as EGFR gene amplification and gains and losses in genomic regions of chromosomes 7 and 10. Release of CTCs was associated with EGFR gene amplification, suggesting a growth potential of these cells. We demonstrate that hematogenous GBM spread is an intrinsic feature of GBM biology.

U2 - 10.1126/scitranslmed.3009095

DO - 10.1126/scitranslmed.3009095

M3 - SCORING: Journal article

C2 - 25080476

VL - 6

SP - 247ra101

JO - SCI TRANSL MED

JF - SCI TRANSL MED

SN - 1946-6234

IS - 247

ER -