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Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE

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Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE. / Salzer, Helmut J F; Rolling, Thierry; Vinnemeier, Christof D; Tannich, Egbert; Schmiedel, Stefan; Addo, Marylyn M; Cramer, Jakob P.

In: TRAVEL MED INFECT DI, Vol. 20, 09.09.2017, p. 49-55.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Salzer, HJF, Rolling, T, Vinnemeier, CD, Tannich, E, Schmiedel, S, Addo, MM & Cramer, JP 2017, 'Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE', TRAVEL MED INFECT DI, vol. 20, pp. 49-55. https://doi.org/10.1016/j.tmaid.2017.09.001

APA

Salzer, H. J. F., Rolling, T., Vinnemeier, C. D., Tannich, E., Schmiedel, S., Addo, M. M., & Cramer, J. P. (2017). Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE. TRAVEL MED INFECT DI, 20, 49-55. https://doi.org/10.1016/j.tmaid.2017.09.001

Vancouver

Salzer HJF, Rolling T, Vinnemeier CD, Tannich E, Schmiedel S, Addo MM et al. Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE. TRAVEL MED INFECT DI. 2017 Sep 9;20:49-55. https://doi.org/10.1016/j.tmaid.2017.09.001

Bibtex

@article{13d9a99d9c1043fd9a6e7f41f01d445f,
title = "Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE",
abstract = "OBJECTIVES: Eosinophilia in travelers and migrants returning from the tropics is often associated with invasive helminthic infections. Total IgE is considered a useful additional diagnostic parameter; however, both parameters are also increased in various other non-helminthic diseases.METHODS: We retrospectively evaluated travelers and migrants seen at our department between September 2007 and May 2014. Patients with an absolute eosinophil count ≥500 cells/μl were considered for further analyses.RESULTS: Among 6618 returned travelers and migrants, 154 (2.3%) had a total eosinophil count ≥500 cells/μL. Of these, 71 patients (46%) were diagnosed with helminthic infection. In an additional 62 patients (40%) with eosinophilia a final diagnosis was found, including non-helminthic infections in 34 patients and non-infectious causes in 28 patients, while in 21 patients (14%) no diagnosis was made. Patients with helminthic infections had higher eosinophil counts than travelers and migrants with other diagnoses (median 981 vs. 710 cells/μl; p = 0.001), while total IgE levels (n = 70; 172 vs. 152 kU/l; p = 0.731) were similar in both groups.CONCLUSION: Eosinophil count but not total IgE levels are associated with helminthic infections in returning travelers and migrants with eosinophilia. Our results do not support the use of total IgE to differentiate helminthic infections from other causes of eosinophilia in this population.",
keywords = "Adolescent, Adult, Aged, Animals, Child, Child, Preschool, Eosinophilia, Eosinophils, Female, Helminthiasis, Humans, Immunoglobulin E, Immunologic Tests, Male, Medical History Taking, Middle Aged, Retrospective Studies, Transients and Migrants, Travel, Young Adult, Journal Article",
author = "Salzer, {Helmut J F} and Thierry Rolling and Vinnemeier, {Christof D} and Egbert Tannich and Stefan Schmiedel and Addo, {Marylyn M} and Cramer, {Jakob P}",
note = "Copyright {\textcopyright} 2017 Elsevier Ltd. All rights reserved.",
year = "2017",
month = sep,
day = "9",
doi = "10.1016/j.tmaid.2017.09.001",
language = "English",
volume = "20",
pages = "49--55",
journal = "TRAVEL MED INFECT DI",
issn = "1477-8939",
publisher = "Elsevier USA",

}

RIS

TY - JOUR

T1 - Helminthic infections in returning travelers and migrants with eosinophilia: Diagnostic value of medical history, eosinophil count and IgE

AU - Salzer, Helmut J F

AU - Rolling, Thierry

AU - Vinnemeier, Christof D

AU - Tannich, Egbert

AU - Schmiedel, Stefan

AU - Addo, Marylyn M

AU - Cramer, Jakob P

N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.

PY - 2017/9/9

Y1 - 2017/9/9

N2 - OBJECTIVES: Eosinophilia in travelers and migrants returning from the tropics is often associated with invasive helminthic infections. Total IgE is considered a useful additional diagnostic parameter; however, both parameters are also increased in various other non-helminthic diseases.METHODS: We retrospectively evaluated travelers and migrants seen at our department between September 2007 and May 2014. Patients with an absolute eosinophil count ≥500 cells/μl were considered for further analyses.RESULTS: Among 6618 returned travelers and migrants, 154 (2.3%) had a total eosinophil count ≥500 cells/μL. Of these, 71 patients (46%) were diagnosed with helminthic infection. In an additional 62 patients (40%) with eosinophilia a final diagnosis was found, including non-helminthic infections in 34 patients and non-infectious causes in 28 patients, while in 21 patients (14%) no diagnosis was made. Patients with helminthic infections had higher eosinophil counts than travelers and migrants with other diagnoses (median 981 vs. 710 cells/μl; p = 0.001), while total IgE levels (n = 70; 172 vs. 152 kU/l; p = 0.731) were similar in both groups.CONCLUSION: Eosinophil count but not total IgE levels are associated with helminthic infections in returning travelers and migrants with eosinophilia. Our results do not support the use of total IgE to differentiate helminthic infections from other causes of eosinophilia in this population.

AB - OBJECTIVES: Eosinophilia in travelers and migrants returning from the tropics is often associated with invasive helminthic infections. Total IgE is considered a useful additional diagnostic parameter; however, both parameters are also increased in various other non-helminthic diseases.METHODS: We retrospectively evaluated travelers and migrants seen at our department between September 2007 and May 2014. Patients with an absolute eosinophil count ≥500 cells/μl were considered for further analyses.RESULTS: Among 6618 returned travelers and migrants, 154 (2.3%) had a total eosinophil count ≥500 cells/μL. Of these, 71 patients (46%) were diagnosed with helminthic infection. In an additional 62 patients (40%) with eosinophilia a final diagnosis was found, including non-helminthic infections in 34 patients and non-infectious causes in 28 patients, while in 21 patients (14%) no diagnosis was made. Patients with helminthic infections had higher eosinophil counts than travelers and migrants with other diagnoses (median 981 vs. 710 cells/μl; p = 0.001), while total IgE levels (n = 70; 172 vs. 152 kU/l; p = 0.731) were similar in both groups.CONCLUSION: Eosinophil count but not total IgE levels are associated with helminthic infections in returning travelers and migrants with eosinophilia. Our results do not support the use of total IgE to differentiate helminthic infections from other causes of eosinophilia in this population.

KW - Adolescent

KW - Adult

KW - Aged

KW - Animals

KW - Child

KW - Child, Preschool

KW - Eosinophilia

KW - Eosinophils

KW - Female

KW - Helminthiasis

KW - Humans

KW - Immunoglobulin E

KW - Immunologic Tests

KW - Male

KW - Medical History Taking

KW - Middle Aged

KW - Retrospective Studies

KW - Transients and Migrants

KW - Travel

KW - Young Adult

KW - Journal Article

U2 - 10.1016/j.tmaid.2017.09.001

DO - 10.1016/j.tmaid.2017.09.001

M3 - SCORING: Journal article

C2 - 28882532

VL - 20

SP - 49

EP - 55

JO - TRAVEL MED INFECT DI

JF - TRAVEL MED INFECT DI

SN - 1477-8939

ER -