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Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza

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Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza. / Hartmann, Wiebke; Brunn, Marie-Luise; Stetter, Nadine; Gagliani, Nicola; Muscate, Franziska; Stanelle-Bertram, Stephanie; Gabriel, Gülsah; Breloer, Minka.

In: CELL REP, Vol. 29, No. 8, 19.11.2019, p. 2243-2256.e4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hartmann, W, Brunn, M-L, Stetter, N, Gagliani, N, Muscate, F, Stanelle-Bertram, S, Gabriel, G & Breloer, M 2019, 'Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza', CELL REP, vol. 29, no. 8, pp. 2243-2256.e4. https://doi.org/10.1016/j.celrep.2019.10.051

APA

Hartmann, W., Brunn, M-L., Stetter, N., Gagliani, N., Muscate, F., Stanelle-Bertram, S., Gabriel, G., & Breloer, M. (2019). Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza. CELL REP, 29(8), 2243-2256.e4. https://doi.org/10.1016/j.celrep.2019.10.051

Vancouver

Hartmann W, Brunn M-L, Stetter N, Gagliani N, Muscate F, Stanelle-Bertram S et al. Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza. CELL REP. 2019 Nov 19;29(8):2243-2256.e4. https://doi.org/10.1016/j.celrep.2019.10.051

Bibtex

@article{70e106474bf340fdaad851bf52cee158,
title = "Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza",
abstract = "Helminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seasonal influenza. Vaccination-induced protection against challenge infections with the human pathogenic 2009 pandemic H1N1 influenza A virus is drastically impaired in helminth-infected mice. Impaired responses are also observed if vaccinations are performed after clearance of a previous helminth infection, suggesting that individuals in helminth-endemic areas may not always benefit from vaccinations, even in the absence of an acute and diagnosable helminth infection. Mechanistically, the suppression is associated with a systemic and sustained expansion of interleukin (IL)-10-producing CD4+CD49+LAG-3+ type 1 regulatory T cells and partially abrogated by in vivo blockade of the IL-10 receptor.",
author = "Wiebke Hartmann and Marie-Luise Brunn and Nadine Stetter and Nicola Gagliani and Franziska Muscate and Stephanie Stanelle-Bertram and G{\"u}lsah Gabriel and Minka Breloer",
note = "Copyright {\textcopyright} 2019 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2019",
month = nov,
day = "19",
doi = "10.1016/j.celrep.2019.10.051",
language = "English",
volume = "29",
pages = "2243--2256.e4",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Helminth Infections Suppress the Efficacy of Vaccination against Seasonal Influenza

AU - Hartmann, Wiebke

AU - Brunn, Marie-Luise

AU - Stetter, Nadine

AU - Gagliani, Nicola

AU - Muscate, Franziska

AU - Stanelle-Bertram, Stephanie

AU - Gabriel, Gülsah

AU - Breloer, Minka

N1 - Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2019/11/19

Y1 - 2019/11/19

N2 - Helminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seasonal influenza. Vaccination-induced protection against challenge infections with the human pathogenic 2009 pandemic H1N1 influenza A virus is drastically impaired in helminth-infected mice. Impaired responses are also observed if vaccinations are performed after clearance of a previous helminth infection, suggesting that individuals in helminth-endemic areas may not always benefit from vaccinations, even in the absence of an acute and diagnosable helminth infection. Mechanistically, the suppression is associated with a systemic and sustained expansion of interleukin (IL)-10-producing CD4+CD49+LAG-3+ type 1 regulatory T cells and partially abrogated by in vivo blockade of the IL-10 receptor.

AB - Helminth parasites infect more than a quarter of the human population and inflict significant changes to the immunological status of their hosts. Here, we analyze the impact of helminth infections on the efficacy of vaccinations using Litomosoides sigmodontis-infected mice. Concurrent helminth infection reduces the quantity and quality of antibody responses to vaccination against seasonal influenza. Vaccination-induced protection against challenge infections with the human pathogenic 2009 pandemic H1N1 influenza A virus is drastically impaired in helminth-infected mice. Impaired responses are also observed if vaccinations are performed after clearance of a previous helminth infection, suggesting that individuals in helminth-endemic areas may not always benefit from vaccinations, even in the absence of an acute and diagnosable helminth infection. Mechanistically, the suppression is associated with a systemic and sustained expansion of interleukin (IL)-10-producing CD4+CD49+LAG-3+ type 1 regulatory T cells and partially abrogated by in vivo blockade of the IL-10 receptor.

U2 - 10.1016/j.celrep.2019.10.051

DO - 10.1016/j.celrep.2019.10.051

M3 - SCORING: Journal article

C2 - 31747598

VL - 29

SP - 2243-2256.e4

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 8

ER -