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Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

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Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization. / Zhang, Ben; Shu, Xiao-Ou; Delahanty, Ryan J; Zeng, Chenjie; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Wen, Wanqing; Long, Jirong; Li, Chun; Dunning, Alison M; Chang-Claude, Jenny; Shah, Mitul; Perkins, Barbara J; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Bojesen, Stig E; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Lambrechts, Diether; Neven, Patrick; Wildiers, Hans; Floris, Giuseppe; Schmidt, Marjanka K; Rookus, Matti A; van den Hurk, Katja; de Kort, Wim L A M; Couch, Fergus J; Olson, Janet E; Hallberg, Emily; Vachon, Celine; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Peto, Julian; Dos-Santos-Silva, Isabel; Fletcher, Olivia; Johnson, Nichola; Nevanlinna, Heli; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Li, Jingmei; Humphreys, Keith; Brand, Judith; Guénel, Pascal; Truong, Thérèse; Cordina-Duverger, Emilie; Menegaux, Florence; Burwinkel, Barbara; Marme, Frederik; Yang, Rongxi; Surowy, Harald; Benitez, Javier; Zamora, M Pilar; Perez, Jose I A; Cox, Angela; Cross, Simon S; Reed, Malcolm W R; Andrulis, Irene L; Knight, Julia A; Glendon, Gord; Tchatchou, Sandrine; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Chenevix-Trench, Georgia; Haiman, Christopher A; Henderson, Brian E; Schumacher, Fredrick; Marchand, Loic Le; Lindblom, Annika; Margolin, Sara; Hooning, Maartje J; Martens, John W M; Tilanus-Linthorst, Madeleine M A; Collée, J Margriet; Hopper, John L; Southey, Melissa C; Tsimiklis, Helen; Apicella, Carmel; Slager, Susan; Toland, Amanda E; Ambrosone, Christine B; Yannoukakos, Drakoulis; Giles, Graham G; Milne, Roger L; McLean, Catriona; Fasching, Peter A; Haeberle, Lothar; Ekici, Arif B; Beckmann, Matthias W; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Swerdlow, Anthony J; Ashworth, Alan; Orr, Nick; Jones, Michael; Figueroa, Jonine; Garcia-Closas, Montserrat; Brinton, Louise; Lissowska, Jolanta; Dumont, Martine; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Brauch, Hiltrud; Brüning, Thomas; Ko, Yon-Dschun; Peterlongo, Paolo; Manoukian, Siranoush; Bonanni, Bernardo; Radice, Paolo; Bogdanova, Natalia; Antonenkova, Natalia; Dörk, Thilo; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Devilee, Peter; Seynaeve, Caroline; Van Asperen, Christi J; Jakubowska, Anna; Lubiński, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Hamann, Ute; Torres, Diana; Schmutzler, Rita K; Neuhausen, Susan L; Anton-Culver, Hoda; Kristensen, Vessela N; Grenaker Alnæs, Grethe I; Pierce, Brandon L; Kraft, Peter; Peters, Ulrike; Lindstrom, Sara; Seminara, Daniela; Burgess, Stephen; Ahsan, Habibul; Whittemore, Alice S; John, Esther M; Gammon, Marilie D; Malone, Kathleen E; Tessier, Daniel C; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Ahmed, Shahana; Maranian, Mel; Healey, Catherine S; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Álvarez, Nuria; Herrero, Daniel; Pharoah, Paul D P; Simard, Jacques; Hall, Per; Hunter, David J; Easton, Douglas F; Zheng, Wei; kConFab Investigators, Australian Ovarian Study Group.

In: JNCI-J NATL CANCER I, Vol. 107, No. 11, 11.2015, p. djv219.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Zhang, B, Shu, X-O, Delahanty, RJ, Zeng, C, Michailidou, K, Bolla, MK, Wang, Q, Dennis, J, Wen, W, Long, J, Li, C, Dunning, AM, Chang-Claude, J, Shah, M, Perkins, BJ, Czene, K, Darabi, H, Eriksson, M, Bojesen, SE, Nordestgaard, BG, Nielsen, SF, Flyger, H, Lambrechts, D, Neven, P, Wildiers, H, Floris, G, Schmidt, MK, Rookus, MA, van den Hurk, K, de Kort, WLAM, Couch, FJ, Olson, JE, Hallberg, E, Vachon, C, Rudolph, A, Seibold, P, Flesch-Janys, D, Peto, J, Dos-Santos-Silva, I, Fletcher, O, Johnson, N, Nevanlinna, H, Muranen, TA, Aittomäki, K, Blomqvist, C, Li, J, Humphreys, K, Brand, J, Guénel, P, Truong, T, Cordina-Duverger, E, Menegaux, F, Burwinkel, B, Marme, F, Yang, R, Surowy, H, Benitez, J, Zamora, MP, Perez, JIA, Cox, A, Cross, SS, Reed, MWR, Andrulis, IL, Knight, JA, Glendon, G, Tchatchou, S, Sawyer, EJ, Tomlinson, I, Kerin, MJ, Miller, N, Chenevix-Trench, G, Haiman, CA, Henderson, BE, Schumacher, F, Marchand, LL, Lindblom, A, Margolin, S, Hooning, MJ, Martens, JWM, Tilanus-Linthorst, MMA, Collée, JM, Hopper, JL, Southey, MC, Tsimiklis, H, Apicella, C, Slager, S, Toland, AE, Ambrosone, CB, Yannoukakos, D, Giles, GG, Milne, RL, McLean, C, Fasching, PA, Haeberle, L, Ekici, AB, Beckmann, MW, Brenner, H, Dieffenbach, AK, Arndt, V, Stegmaier, C, Swerdlow, AJ, Ashworth, A, Orr, N, Jones, M, Figueroa, J, Garcia-Closas, M, Brinton, L, Lissowska, J, Dumont, M, Winqvist, R, Pylkäs, K, Jukkola-Vuorinen, A, Grip, M, Brauch, H, Brüning, T, Ko, Y-D, Peterlongo, P, Manoukian, S, Bonanni, B, Radice, P, Bogdanova, N, Antonenkova, N, Dörk, T, Mannermaa, A, Kataja, V, Kosma, V-M, Hartikainen, JM, Devilee, P, Seynaeve, C, Van Asperen, CJ, Jakubowska, A, Lubiński, J, Jaworska-Bieniek, K, Durda, K, Hamann, U, Torres, D, Schmutzler, RK, Neuhausen, SL, Anton-Culver, H, Kristensen, VN, Grenaker Alnæs, GI, Pierce, BL, Kraft, P, Peters, U, Lindstrom, S, Seminara, D, Burgess, S, Ahsan, H, Whittemore, AS, John, EM, Gammon, MD, Malone, KE, Tessier, DC, Vincent, D, Bacot, F, Luccarini, C, Baynes, C, Ahmed, S, Maranian, M, Healey, CS, González-Neira, A, Pita, G, Alonso, MR, Álvarez, N, Herrero, D, Pharoah, PDP, Simard, J, Hall, P, Hunter, DJ, Easton, DF, Zheng, W & kConFab Investigators, Australian Ovarian Study Group 2015, 'Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization', JNCI-J NATL CANCER I, vol. 107, no. 11, pp. djv219. https://doi.org/10.1093/jnci/djv219

APA

Zhang, B., Shu, X-O., Delahanty, R. J., Zeng, C., Michailidou, K., Bolla, M. K., Wang, Q., Dennis, J., Wen, W., Long, J., Li, C., Dunning, A. M., Chang-Claude, J., Shah, M., Perkins, B. J., Czene, K., Darabi, H., Eriksson, M., Bojesen, S. E., ... kConFab Investigators, Australian Ovarian Study Group (2015). Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization. JNCI-J NATL CANCER I, 107(11), djv219. https://doi.org/10.1093/jnci/djv219

Vancouver

Zhang B, Shu X-O, Delahanty RJ, Zeng C, Michailidou K, Bolla MK et al. Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization. JNCI-J NATL CANCER I. 2015 Nov;107(11):djv219. https://doi.org/10.1093/jnci/djv219

Bibtex

@article{68a3adf8e8844d6f8611b2fa2e4fc6cf,
title = "Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization",
abstract = "BACKGROUND: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.METHODS: We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control patients, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16003 case patients and 41335 control patients.RESULTS: The pooled relative risk of breast cancer was 1.17 (95% confidence interval [CI] = 1.15 to 1.19) per 10cm increase in height in the meta-analysis of prospective studies. In Mendelian randomization analysis, the odds ratio of breast cancer per 10cm increase in genetically predicted height was 1.22 (95% CI = 1.13 to 1.32) in the first consortium and 1.21 (95% CI = 1.05 to 1.39) in the second consortium. The association was found in both premenopausal and postmenopausal women but restricted to hormone receptor-positive breast cancer. Analyses of height-associated variants identified eight new loci associated with breast cancer risk after adjusting for multiple comparisons, including three loci at 1q21.2, DNAJC27, and CCDC91 at genome-wide significance level P < 5×10(-8).CONCLUSIONS: Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.",
keywords = "Body Height, Breast Neoplasms, Evidence-Based Medicine, Female, Humans, Mendelian Randomization Analysis, Odds Ratio, Prospective Studies, Risk Factors",
author = "Ben Zhang and Xiao-Ou Shu and Delahanty, {Ryan J} and Chenjie Zeng and Kyriaki Michailidou and Bolla, {Manjeet K} and Qin Wang and Joe Dennis and Wanqing Wen and Jirong Long and Chun Li and Dunning, {Alison M} and Jenny Chang-Claude and Mitul Shah and Perkins, {Barbara J} and Kamila Czene and Hatef Darabi and Mikael Eriksson and Bojesen, {Stig E} and Nordestgaard, {B{\o}rge G} and Nielsen, {Sune F} and Henrik Flyger and Diether Lambrechts and Patrick Neven and Hans Wildiers and Giuseppe Floris and Schmidt, {Marjanka K} and Rookus, {Matti A} and {van den Hurk}, Katja and {de Kort}, {Wim L A M} and Couch, {Fergus J} and Olson, {Janet E} and Emily Hallberg and Celine Vachon and Anja Rudolph and Petra Seibold and Dieter Flesch-Janys and Julian Peto and Isabel Dos-Santos-Silva and Olivia Fletcher and Nichola Johnson and Heli Nevanlinna and Muranen, {Taru A} and Kristiina Aittom{\"a}ki and Carl Blomqvist and Jingmei Li and Keith Humphreys and Judith Brand and Pascal Gu{\'e}nel and Th{\'e}r{\`e}se Truong and Emilie Cordina-Duverger and Florence Menegaux and Barbara Burwinkel and Frederik Marme and Rongxi Yang and Harald Surowy and Javier Benitez and Zamora, {M Pilar} and Perez, {Jose I A} and Angela Cox and Cross, {Simon S} and Reed, {Malcolm W R} and Andrulis, {Irene L} and Knight, {Julia A} and Gord Glendon and Sandrine Tchatchou and Sawyer, {Elinor J} and Ian Tomlinson and Kerin, {Michael J} and Nicola Miller and Georgia Chenevix-Trench and Haiman, {Christopher A} and Henderson, {Brian E} and Fredrick Schumacher and Marchand, {Loic Le} and Annika Lindblom and Sara Margolin and Hooning, {Maartje J} and Martens, {John W M} and Tilanus-Linthorst, {Madeleine M A} and Coll{\'e}e, {J Margriet} and Hopper, {John L} and Southey, {Melissa C} and Helen Tsimiklis and Carmel Apicella and Susan Slager and Toland, {Amanda E} and Ambrosone, {Christine B} and Drakoulis Yannoukakos and Giles, {Graham G} and Milne, {Roger L} and Catriona McLean and Fasching, {Peter A} and Lothar Haeberle and Ekici, {Arif B} and Beckmann, {Matthias W} and Hermann Brenner and Dieffenbach, {Aida Karina} and Volker Arndt and Christa Stegmaier and Swerdlow, {Anthony J} and Alan Ashworth and Nick Orr and Michael Jones and Jonine Figueroa and Montserrat Garcia-Closas and Louise Brinton and Jolanta Lissowska and Martine Dumont and Robert Winqvist and Katri Pylk{\"a}s and Arja Jukkola-Vuorinen and Mervi Grip and Hiltrud Brauch and Thomas Br{\"u}ning and Yon-Dschun Ko and Paolo Peterlongo and Siranoush Manoukian and Bernardo Bonanni and Paolo Radice and Natalia Bogdanova and Natalia Antonenkova and Thilo D{\"o}rk and Arto Mannermaa and Vesa Kataja and Veli-Matti Kosma and Hartikainen, {Jaana M} and Peter Devilee and Caroline Seynaeve and {Van Asperen}, {Christi J} and Anna Jakubowska and Jan Lubi{\'n}ski and Katarzyna Jaworska-Bieniek and Katarzyna Durda and Ute Hamann and Diana Torres and Schmutzler, {Rita K} and Neuhausen, {Susan L} and Hoda Anton-Culver and Kristensen, {Vessela N} and {Grenaker Aln{\ae}s}, {Grethe I} and Pierce, {Brandon L} and Peter Kraft and Ulrike Peters and Sara Lindstrom and Daniela Seminara and Stephen Burgess and Habibul Ahsan and Whittemore, {Alice S} and John, {Esther M} and Gammon, {Marilie D} and Malone, {Kathleen E} and Tessier, {Daniel C} and Daniel Vincent and Francois Bacot and Craig Luccarini and Caroline Baynes and Shahana Ahmed and Mel Maranian and Healey, {Catherine S} and Anna Gonz{\'a}lez-Neira and Guillermo Pita and Alonso, {M Rosario} and Nuria {\'A}lvarez and Daniel Herrero and Pharoah, {Paul D P} and Jacques Simard and Per Hall and Hunter, {David J} and Easton, {Douglas F} and Wei Zheng and {kConFab Investigators, Australian Ovarian Study Group}",
note = "{\textcopyright} The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.",
year = "2015",
month = nov,
doi = "10.1093/jnci/djv219",
language = "English",
volume = "107",
pages = "djv219",
journal = "JNCI-J NATL CANCER I",
issn = "0027-8874",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Height and Breast Cancer Risk: Evidence From Prospective Studies and Mendelian Randomization

AU - Zhang, Ben

AU - Shu, Xiao-Ou

AU - Delahanty, Ryan J

AU - Zeng, Chenjie

AU - Michailidou, Kyriaki

AU - Bolla, Manjeet K

AU - Wang, Qin

AU - Dennis, Joe

AU - Wen, Wanqing

AU - Long, Jirong

AU - Li, Chun

AU - Dunning, Alison M

AU - Chang-Claude, Jenny

AU - Shah, Mitul

AU - Perkins, Barbara J

AU - Czene, Kamila

AU - Darabi, Hatef

AU - Eriksson, Mikael

AU - Bojesen, Stig E

AU - Nordestgaard, Børge G

AU - Nielsen, Sune F

AU - Flyger, Henrik

AU - Lambrechts, Diether

AU - Neven, Patrick

AU - Wildiers, Hans

AU - Floris, Giuseppe

AU - Schmidt, Marjanka K

AU - Rookus, Matti A

AU - van den Hurk, Katja

AU - de Kort, Wim L A M

AU - Couch, Fergus J

AU - Olson, Janet E

AU - Hallberg, Emily

AU - Vachon, Celine

AU - Rudolph, Anja

AU - Seibold, Petra

AU - Flesch-Janys, Dieter

AU - Peto, Julian

AU - Dos-Santos-Silva, Isabel

AU - Fletcher, Olivia

AU - Johnson, Nichola

AU - Nevanlinna, Heli

AU - Muranen, Taru A

AU - Aittomäki, Kristiina

AU - Blomqvist, Carl

AU - Li, Jingmei

AU - Humphreys, Keith

AU - Brand, Judith

AU - Guénel, Pascal

AU - Truong, Thérèse

AU - Cordina-Duverger, Emilie

AU - Menegaux, Florence

AU - Burwinkel, Barbara

AU - Marme, Frederik

AU - Yang, Rongxi

AU - Surowy, Harald

AU - Benitez, Javier

AU - Zamora, M Pilar

AU - Perez, Jose I A

AU - Cox, Angela

AU - Cross, Simon S

AU - Reed, Malcolm W R

AU - Andrulis, Irene L

AU - Knight, Julia A

AU - Glendon, Gord

AU - Tchatchou, Sandrine

AU - Sawyer, Elinor J

AU - Tomlinson, Ian

AU - Kerin, Michael J

AU - Miller, Nicola

AU - Chenevix-Trench, Georgia

AU - Haiman, Christopher A

AU - Henderson, Brian E

AU - Schumacher, Fredrick

AU - Marchand, Loic Le

AU - Lindblom, Annika

AU - Margolin, Sara

AU - Hooning, Maartje J

AU - Martens, John W M

AU - Tilanus-Linthorst, Madeleine M A

AU - Collée, J Margriet

AU - Hopper, John L

AU - Southey, Melissa C

AU - Tsimiklis, Helen

AU - Apicella, Carmel

AU - Slager, Susan

AU - Toland, Amanda E

AU - Ambrosone, Christine B

AU - Yannoukakos, Drakoulis

AU - Giles, Graham G

AU - Milne, Roger L

AU - McLean, Catriona

AU - Fasching, Peter A

AU - Haeberle, Lothar

AU - Ekici, Arif B

AU - Beckmann, Matthias W

AU - Brenner, Hermann

AU - Dieffenbach, Aida Karina

AU - Arndt, Volker

AU - Stegmaier, Christa

AU - Swerdlow, Anthony J

AU - Ashworth, Alan

AU - Orr, Nick

AU - Jones, Michael

AU - Figueroa, Jonine

AU - Garcia-Closas, Montserrat

AU - Brinton, Louise

AU - Lissowska, Jolanta

AU - Dumont, Martine

AU - Winqvist, Robert

AU - Pylkäs, Katri

AU - Jukkola-Vuorinen, Arja

AU - Grip, Mervi

AU - Brauch, Hiltrud

AU - Brüning, Thomas

AU - Ko, Yon-Dschun

AU - Peterlongo, Paolo

AU - Manoukian, Siranoush

AU - Bonanni, Bernardo

AU - Radice, Paolo

AU - Bogdanova, Natalia

AU - Antonenkova, Natalia

AU - Dörk, Thilo

AU - Mannermaa, Arto

AU - Kataja, Vesa

AU - Kosma, Veli-Matti

AU - Hartikainen, Jaana M

AU - Devilee, Peter

AU - Seynaeve, Caroline

AU - Van Asperen, Christi J

AU - Jakubowska, Anna

AU - Lubiński, Jan

AU - Jaworska-Bieniek, Katarzyna

AU - Durda, Katarzyna

AU - Hamann, Ute

AU - Torres, Diana

AU - Schmutzler, Rita K

AU - Neuhausen, Susan L

AU - Anton-Culver, Hoda

AU - Kristensen, Vessela N

AU - Grenaker Alnæs, Grethe I

AU - Pierce, Brandon L

AU - Kraft, Peter

AU - Peters, Ulrike

AU - Lindstrom, Sara

AU - Seminara, Daniela

AU - Burgess, Stephen

AU - Ahsan, Habibul

AU - Whittemore, Alice S

AU - John, Esther M

AU - Gammon, Marilie D

AU - Malone, Kathleen E

AU - Tessier, Daniel C

AU - Vincent, Daniel

AU - Bacot, Francois

AU - Luccarini, Craig

AU - Baynes, Caroline

AU - Ahmed, Shahana

AU - Maranian, Mel

AU - Healey, Catherine S

AU - González-Neira, Anna

AU - Pita, Guillermo

AU - Alonso, M Rosario

AU - Álvarez, Nuria

AU - Herrero, Daniel

AU - Pharoah, Paul D P

AU - Simard, Jacques

AU - Hall, Per

AU - Hunter, David J

AU - Easton, Douglas F

AU - Zheng, Wei

AU - kConFab Investigators, Australian Ovarian Study Group

N1 - © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

PY - 2015/11

Y1 - 2015/11

N2 - BACKGROUND: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.METHODS: We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control patients, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16003 case patients and 41335 control patients.RESULTS: The pooled relative risk of breast cancer was 1.17 (95% confidence interval [CI] = 1.15 to 1.19) per 10cm increase in height in the meta-analysis of prospective studies. In Mendelian randomization analysis, the odds ratio of breast cancer per 10cm increase in genetically predicted height was 1.22 (95% CI = 1.13 to 1.32) in the first consortium and 1.21 (95% CI = 1.05 to 1.39) in the second consortium. The association was found in both premenopausal and postmenopausal women but restricted to hormone receptor-positive breast cancer. Analyses of height-associated variants identified eight new loci associated with breast cancer risk after adjusting for multiple comparisons, including three loci at 1q21.2, DNAJC27, and CCDC91 at genome-wide significance level P < 5×10(-8).CONCLUSIONS: Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.

AB - BACKGROUND: Epidemiological studies have linked adult height with breast cancer risk in women. However, the magnitude of the association, particularly by subtypes of breast cancer, has not been established. Furthermore, the mechanisms of the association remain unclear.METHODS: We performed a meta-analysis to investigate associations between height and breast cancer risk using data from 159 prospective cohorts totaling 5216302 women, including 113178 events. In a consortium with individual-level data from 46325 case patients and 42482 control patients, we conducted a Mendelian randomization analysis using a genetic score that comprised 168 height-associated variants as an instrument. This association was further evaluated in a second consortium using summary statistics data from 16003 case patients and 41335 control patients.RESULTS: The pooled relative risk of breast cancer was 1.17 (95% confidence interval [CI] = 1.15 to 1.19) per 10cm increase in height in the meta-analysis of prospective studies. In Mendelian randomization analysis, the odds ratio of breast cancer per 10cm increase in genetically predicted height was 1.22 (95% CI = 1.13 to 1.32) in the first consortium and 1.21 (95% CI = 1.05 to 1.39) in the second consortium. The association was found in both premenopausal and postmenopausal women but restricted to hormone receptor-positive breast cancer. Analyses of height-associated variants identified eight new loci associated with breast cancer risk after adjusting for multiple comparisons, including three loci at 1q21.2, DNAJC27, and CCDC91 at genome-wide significance level P < 5×10(-8).CONCLUSIONS: Our study provides strong evidence that adult height is a risk factor for breast cancer in women and certain genetic factors and biological pathways affecting adult height have an important role in the etiology of breast cancer.

KW - Body Height

KW - Breast Neoplasms

KW - Evidence-Based Medicine

KW - Female

KW - Humans

KW - Mendelian Randomization Analysis

KW - Odds Ratio

KW - Prospective Studies

KW - Risk Factors

U2 - 10.1093/jnci/djv219

DO - 10.1093/jnci/djv219

M3 - SCORING: Journal article

C2 - 26296642

VL - 107

SP - djv219

JO - JNCI-J NATL CANCER I

JF - JNCI-J NATL CANCER I

SN - 0027-8874

IS - 11

ER -