Heat generation during ablation of porcine skin with erbium:YAG laser vs a novel picosecond infrared laser

TY - JOUR

T1 - Heat generation during ablation of porcine skin with erbium:YAG laser vs a novel picosecond infrared laser

AU - Jowett, Nathan

AU - Wöllmer, Wolfgang

AU - Mlynarek, Alex M

AU - Wiseman, Paul

AU - Segal, Bernard

AU - Franjic, Kresimir

AU - Krötz, Peter

AU - Böttcher, Arne

AU - Knecht, Rainald

AU - Miller, R J Dwayne

PY - 2013/8/1

Y1 - 2013/8/1

N2 - IMPORTANCE: Despite significant advances in surgery, most surgical tools remain basic. Lasers provide a means of precise surgical ablation, but their clinical use has remained limited because of undesired thermal, ionizing, or acoustic stress effects leading to tissue injury. A novel ultrafast, nonionizing, picosecond infrared laser (PIRL) system has recently been developed and is capable, in theory, of ablation with negligible thermal or acoustic stress effects.OBJECTIVE: To measure and compare heat generation by means of thermography during ablation of ex vivo porcine skin by conventional microsecond-pulsed erbium:YAG (Er:YAG) laser and picosecond infrared laser (PIRL).DESIGN AND SETTING: This study was conducted in an optics laboratory and used a pretest-posttest experimental design comparing 2 methods of laser ablation of tissue with each sample acting as its own control.INTERVENTION: Ex vivo porcine skin was ablated in a 5-mm line pattern with both Er:YAG laser and PIRL at fluence levels marginally above ablation threshold (2 J/cm² and 0.6 J/cm², respectively).MAIN OUTCOMES AND MEASURES: Peaks and maxima of skin temperature rises were determined using a thermography camera. Means of peak temperature rises were compared using the paired sample t test. Ablation craters were assessed by means of digital microscopy. RESULTS Mean peak rise in skin surface temperature for the Er:YAG laser and PIRL was 15.0°C and 1.68°C, respectively (P < .001). Maximum peak rise in skin surface temperature was 18.85°C for the Er:YAG laser and 2.05°C for the PIRL. Ablation craters were confirmed on digital microscopy.CONCLUSIONS AND RELEVANCE: Picosecond infrared laser ablation results in negligible heat generation, considerably less than Er:YAG laser ablation, which confirms the potential of this novel technology in minimizing undesirable thermal injury associated with lasers currently in clinical use.

AB - IMPORTANCE: Despite significant advances in surgery, most surgical tools remain basic. Lasers provide a means of precise surgical ablation, but their clinical use has remained limited because of undesired thermal, ionizing, or acoustic stress effects leading to tissue injury. A novel ultrafast, nonionizing, picosecond infrared laser (PIRL) system has recently been developed and is capable, in theory, of ablation with negligible thermal or acoustic stress effects.OBJECTIVE: To measure and compare heat generation by means of thermography during ablation of ex vivo porcine skin by conventional microsecond-pulsed erbium:YAG (Er:YAG) laser and picosecond infrared laser (PIRL).DESIGN AND SETTING: This study was conducted in an optics laboratory and used a pretest-posttest experimental design comparing 2 methods of laser ablation of tissue with each sample acting as its own control.INTERVENTION: Ex vivo porcine skin was ablated in a 5-mm line pattern with both Er:YAG laser and PIRL at fluence levels marginally above ablation threshold (2 J/cm² and 0.6 J/cm², respectively).MAIN OUTCOMES AND MEASURES: Peaks and maxima of skin temperature rises were determined using a thermography camera. Means of peak temperature rises were compared using the paired sample t test. Ablation craters were assessed by means of digital microscopy. RESULTS Mean peak rise in skin surface temperature for the Er:YAG laser and PIRL was 15.0°C and 1.68°C, respectively (P < .001). Maximum peak rise in skin surface temperature was 18.85°C for the Er:YAG laser and 2.05°C for the PIRL. Ablation craters were confirmed on digital microscopy.CONCLUSIONS AND RELEVANCE: Picosecond infrared laser ablation results in negligible heat generation, considerably less than Er:YAG laser ablation, which confirms the potential of this novel technology in minimizing undesirable thermal injury associated with lasers currently in clinical use.

KW - Animals

KW - Epidermis

KW - Hot Temperature

KW - Infrared Rays

KW - Laser Therapy

KW - Lasers, Solid-State

KW - Models, Animal

KW - Sensitivity and Specificity

KW - Swine

KW - Thermography

U2 - 10.1001/jamaoto.2013.3974

DO - 10.1001/jamaoto.2013.3974

M3 - SCORING: Journal article

C2 - 23949359

VL - 139

SP - 828

EP - 833

JO - JAMA OTOLARYNGOL

JF - JAMA OTOLARYNGOL

SN - 2168-6181

IS - 8

ER -