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Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases

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Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases : results from the Gutenberg Health Study. / Münzel, Thomas; Hahad, Omar; Gori, Tommaso; Hollmann, Sebastian; Arnold, Natalie; Prochaska, Jürgen H; Schulz, Andreas; Beutel, Manfred; Pfeiffer, Norbert; Schmidtmann, Irene; Lackner, Karl J; Keaney, John F; Wild, Philipp S.

In: CLIN RES CARDIOL, Vol. 108, No. 12, 12.2019, p. 1313-1323.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research

Harvard

Münzel, T, Hahad, O, Gori, T, Hollmann, S, Arnold, N, Prochaska, JH, Schulz, A, Beutel, M, Pfeiffer, N, Schmidtmann, I, Lackner, KJ, Keaney, JF & Wild, PS 2019, 'Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study', CLIN RES CARDIOL, vol. 108, no. 12, pp. 1313-1323. https://doi.org/10.1007/s00392-019-01466-2

APA

Münzel, T., Hahad, O., Gori, T., Hollmann, S., Arnold, N., Prochaska, J. H., Schulz, A., Beutel, M., Pfeiffer, N., Schmidtmann, I., Lackner, K. J., Keaney, J. F., & Wild, P. S. (2019). Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study. CLIN RES CARDIOL, 108(12), 1313-1323. https://doi.org/10.1007/s00392-019-01466-2

Vancouver

Münzel T, Hahad O, Gori T, Hollmann S, Arnold N, Prochaska JH et al. Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study. CLIN RES CARDIOL. 2019 Dec;108(12):1313-1323. https://doi.org/10.1007/s00392-019-01466-2

Bibtex

@article{2937139575ba492e93bbdf2ece99c926,
title = "Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases: results from the Gutenberg Health Study",
abstract = "BACKGROUND: Higher, but also lower resting heart rate (HR), has been associated with increased cardiovascular events and mortality. Little is known about the interplay between HR, cardiovascular risk factors, concomitant diseases, vascular (endothelial) function, neurohormonal biomarkers, and all-cause mortality in the general population. Thus, we aimed to investigate these relationships in a population-based cohort.METHODS: 15,010 individuals (aged 35-74 at enrolment in 2007-2012) from the Gutenberg Health Study were analyzed. Multivariable regression modeling was used to assess the relation between the variables and conditional density plots were generated for cardiovascular risk factors, diseases, and mortality to show their dependence on HR.RESULTS: There were 714 deaths in the total sample at 7.67 ± 1.68 years of follow-up. The prevalence of diabetes mellitus, arterial hypertension, coronary and peripheral artery disease, chronic heart failure, and previous myocardial infarction exhibited a J-shaped association with HR. Mortality showed a similar relation with a nadir of 64 beats per minute (bpm) in the total sample. Each 10 bpm HR reduction in HR < 64 subjects was independently associated with increased mortality (Hazard Ratio 1.36; 95% confidence interval 1.06-1.75). This increased risk was also present in HR > 64 subjects (Hazard Ratio 1.29; 95% confidence interval 1.19-1.41 per 10 bpm increase in HR). Results found for vascular and neurohormonal biomarkers exhibited a differential picture in subjects with a HR below and above the nadir.DISCUSSION: These results indicate that in addition to a higher HR, a lower HR is associated with increased mortality.",
keywords = "Adult, Aged, Asymptomatic Diseases, Cardiovascular Diseases/diagnosis, Cause of Death, Female, Germany/epidemiology, Heart Rate, Humans, Male, Middle Aged, Prevalence, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Time Factors",
author = "Thomas M{\"u}nzel and Omar Hahad and Tommaso Gori and Sebastian Hollmann and Natalie Arnold and Prochaska, {J{\"u}rgen H} and Andreas Schulz and Manfred Beutel and Norbert Pfeiffer and Irene Schmidtmann and Lackner, {Karl J} and Keaney, {John F} and Wild, {Philipp S}",
year = "2019",
month = dec,
doi = "10.1007/s00392-019-01466-2",
language = "English",
volume = "108",
pages = "1313--1323",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "12",

}

RIS

TY - JOUR

T1 - Heart rate, mortality, and the relation with clinical and subclinical cardiovascular diseases

T2 - results from the Gutenberg Health Study

AU - Münzel, Thomas

AU - Hahad, Omar

AU - Gori, Tommaso

AU - Hollmann, Sebastian

AU - Arnold, Natalie

AU - Prochaska, Jürgen H

AU - Schulz, Andreas

AU - Beutel, Manfred

AU - Pfeiffer, Norbert

AU - Schmidtmann, Irene

AU - Lackner, Karl J

AU - Keaney, John F

AU - Wild, Philipp S

PY - 2019/12

Y1 - 2019/12

N2 - BACKGROUND: Higher, but also lower resting heart rate (HR), has been associated with increased cardiovascular events and mortality. Little is known about the interplay between HR, cardiovascular risk factors, concomitant diseases, vascular (endothelial) function, neurohormonal biomarkers, and all-cause mortality in the general population. Thus, we aimed to investigate these relationships in a population-based cohort.METHODS: 15,010 individuals (aged 35-74 at enrolment in 2007-2012) from the Gutenberg Health Study were analyzed. Multivariable regression modeling was used to assess the relation between the variables and conditional density plots were generated for cardiovascular risk factors, diseases, and mortality to show their dependence on HR.RESULTS: There were 714 deaths in the total sample at 7.67 ± 1.68 years of follow-up. The prevalence of diabetes mellitus, arterial hypertension, coronary and peripheral artery disease, chronic heart failure, and previous myocardial infarction exhibited a J-shaped association with HR. Mortality showed a similar relation with a nadir of 64 beats per minute (bpm) in the total sample. Each 10 bpm HR reduction in HR < 64 subjects was independently associated with increased mortality (Hazard Ratio 1.36; 95% confidence interval 1.06-1.75). This increased risk was also present in HR > 64 subjects (Hazard Ratio 1.29; 95% confidence interval 1.19-1.41 per 10 bpm increase in HR). Results found for vascular and neurohormonal biomarkers exhibited a differential picture in subjects with a HR below and above the nadir.DISCUSSION: These results indicate that in addition to a higher HR, a lower HR is associated with increased mortality.

AB - BACKGROUND: Higher, but also lower resting heart rate (HR), has been associated with increased cardiovascular events and mortality. Little is known about the interplay between HR, cardiovascular risk factors, concomitant diseases, vascular (endothelial) function, neurohormonal biomarkers, and all-cause mortality in the general population. Thus, we aimed to investigate these relationships in a population-based cohort.METHODS: 15,010 individuals (aged 35-74 at enrolment in 2007-2012) from the Gutenberg Health Study were analyzed. Multivariable regression modeling was used to assess the relation between the variables and conditional density plots were generated for cardiovascular risk factors, diseases, and mortality to show their dependence on HR.RESULTS: There were 714 deaths in the total sample at 7.67 ± 1.68 years of follow-up. The prevalence of diabetes mellitus, arterial hypertension, coronary and peripheral artery disease, chronic heart failure, and previous myocardial infarction exhibited a J-shaped association with HR. Mortality showed a similar relation with a nadir of 64 beats per minute (bpm) in the total sample. Each 10 bpm HR reduction in HR < 64 subjects was independently associated with increased mortality (Hazard Ratio 1.36; 95% confidence interval 1.06-1.75). This increased risk was also present in HR > 64 subjects (Hazard Ratio 1.29; 95% confidence interval 1.19-1.41 per 10 bpm increase in HR). Results found for vascular and neurohormonal biomarkers exhibited a differential picture in subjects with a HR below and above the nadir.DISCUSSION: These results indicate that in addition to a higher HR, a lower HR is associated with increased mortality.

KW - Adult

KW - Aged

KW - Asymptomatic Diseases

KW - Cardiovascular Diseases/diagnosis

KW - Cause of Death

KW - Female

KW - Germany/epidemiology

KW - Heart Rate

KW - Humans

KW - Male

KW - Middle Aged

KW - Prevalence

KW - Prognosis

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Time Factors

U2 - 10.1007/s00392-019-01466-2

DO - 10.1007/s00392-019-01466-2

M3 - SCORING: Journal article

C2 - 30953178

VL - 108

SP - 1313

EP - 1323

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 12

ER -