Health-related quality of life in patients with subarachnoid haemorrhage
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Health-related quality of life in patients with subarachnoid haemorrhage. / Meyer, Bernhard; Ringel, Florian; Winter, Yaroslav; Spottke, Annika; Gharevi, Nadir; Dams, Judith; Balzer-Geldsetzer, Monika; Mueller, Ines K; Klockgether, Thomas; Schramm, Johannes; Urbach, Horst; Dodel, Richard.
In: CEREBROVASC DIS, Vol. 30, No. 4, 2010, p. 423-431.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Health-related quality of life in patients with subarachnoid haemorrhage
AU - Meyer, Bernhard
AU - Ringel, Florian
AU - Winter, Yaroslav
AU - Spottke, Annika
AU - Gharevi, Nadir
AU - Dams, Judith
AU - Balzer-Geldsetzer, Monika
AU - Mueller, Ines K
AU - Klockgether, Thomas
AU - Schramm, Johannes
AU - Urbach, Horst
AU - Dodel, Richard
N1 - Copyright (c) 2010 S. Karger AG, Basel.
PY - 2010
Y1 - 2010
N2 - BACKGROUND: Aneurysmal subarachnoid haemorrhage (SAH) is a devastating disease with high mortality and disability. The data from large longitudinal studies on health-related quality of life (HRQoL) in patients with SAH are limited. The objective was to investigate HRQoL in patients after SAH and to identify predictors of HRQoL.METHODS: 113 patients with aneurysmal SAH were assigned to either neurosurgery (n = 57) or endovascular coiling (n = 56). Clinical assessments (Barthel Index, modified Rankin Scale) and evaluation of HRQoL [36-Item Short-Form Survey, EuroQol (EQ5D), EQ visual analogue scale (EQ VAS)] were performed at discharge, and at 6 and 12 months of follow-up. Independent predictors of HRQoL were determined using multiple regression analysis.RESULTS: HRQoL in SAH patients was considerably reduced compared to the normal population. At discharge, 92.2% of the patients had moderate or severe problems on the EQ5D. The EQ VAS score was 57.8 +/- 19.3. However, HRQoL still showed improvement from 3 months up to 1 year. At 12 months after SAH, the EQ VAS score was approximately 12-14% higher than at discharge. The independent predictors of decreased HRQoL included female gender, severe SAH, functional disability, depression, a lower level of education and the lack of a stable partnership.CONCLUSIONS: The long-term HRQoL outcome after SAH is unfavourable. HRQoL outcome measures should be included in future studies to provide better evidence of the long-term outcomes after SAH. In addition, the independent determinants of HRQoL identified in this study should be considered in the healthcare programmes aimed at increasing the HRQoL in SAH survivors.
AB - BACKGROUND: Aneurysmal subarachnoid haemorrhage (SAH) is a devastating disease with high mortality and disability. The data from large longitudinal studies on health-related quality of life (HRQoL) in patients with SAH are limited. The objective was to investigate HRQoL in patients after SAH and to identify predictors of HRQoL.METHODS: 113 patients with aneurysmal SAH were assigned to either neurosurgery (n = 57) or endovascular coiling (n = 56). Clinical assessments (Barthel Index, modified Rankin Scale) and evaluation of HRQoL [36-Item Short-Form Survey, EuroQol (EQ5D), EQ visual analogue scale (EQ VAS)] were performed at discharge, and at 6 and 12 months of follow-up. Independent predictors of HRQoL were determined using multiple regression analysis.RESULTS: HRQoL in SAH patients was considerably reduced compared to the normal population. At discharge, 92.2% of the patients had moderate or severe problems on the EQ5D. The EQ VAS score was 57.8 +/- 19.3. However, HRQoL still showed improvement from 3 months up to 1 year. At 12 months after SAH, the EQ VAS score was approximately 12-14% higher than at discharge. The independent predictors of decreased HRQoL included female gender, severe SAH, functional disability, depression, a lower level of education and the lack of a stable partnership.CONCLUSIONS: The long-term HRQoL outcome after SAH is unfavourable. HRQoL outcome measures should be included in future studies to provide better evidence of the long-term outcomes after SAH. In addition, the independent determinants of HRQoL identified in this study should be considered in the healthcare programmes aimed at increasing the HRQoL in SAH survivors.
KW - Adult
KW - Aged
KW - Depression
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Neurosurgical Procedures
KW - Outcome Assessment (Health Care)
KW - Pain Measurement
KW - Quality of Life
KW - Retrospective Studies
KW - Risk Factors
KW - Subarachnoid Hemorrhage
KW - Comparative Study
KW - Journal Article
U2 - 10.1159/000317078
DO - 10.1159/000317078
M3 - SCORING: Journal article
C2 - 20720412
VL - 30
SP - 423
EP - 431
JO - CEREBROVASC DIS
JF - CEREBROVASC DIS
SN - 1015-9770
IS - 4
ER -
