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Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings

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Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings. / Heßmann, Philipp; Seeberg, Greta; Reese, Jens Peter; Dams, Judith; Baum, Erika; Müller, Matthias J; Dodel, Richard; Balzer-Geldsetzer, Monika.

In: J ALZHEIMERS DIS, Vol. 51, No. 2, 2016, p. 545-561.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Heßmann, P, Seeberg, G, Reese, JP, Dams, J, Baum, E, Müller, MJ, Dodel, R & Balzer-Geldsetzer, M 2016, 'Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings', J ALZHEIMERS DIS, vol. 51, no. 2, pp. 545-561. https://doi.org/10.3233/JAD-150835

APA

Heßmann, P., Seeberg, G., Reese, J. P., Dams, J., Baum, E., Müller, M. J., Dodel, R., & Balzer-Geldsetzer, M. (2016). Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings. J ALZHEIMERS DIS, 51(2), 545-561. https://doi.org/10.3233/JAD-150835

Vancouver

Heßmann P, Seeberg G, Reese JP, Dams J, Baum E, Müller MJ et al. Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings. J ALZHEIMERS DIS. 2016;51(2):545-561. https://doi.org/10.3233/JAD-150835

Bibtex

@article{ba96f4c6bd7c42c2ad648d951f5cc8e5,
title = "Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings",
abstract = "The purpose of this study is to evaluate the health-related quality of life (HrQoL) of patients with Alzheimer's disease (AD) in different care settings (institutionalized versus community-dwelling) across all severity stages of dementia. Patients were consecutively recruited with their primary caregivers (123 inpatients and 272 outpatients), and the impact of patient-related parameters such as behavioral and psychological symptoms of dementia (BPSD) (Geriatric Depression Scale [GDS] and Neuropsychiatric Inventory [NPI]) and functional capacity (Alzheimer's Disease Cooperative Study-Activities of Daily Living [ADCS-ADL]) on HrQoL was analyzed. Patients' HrQoL was assessed using self-reported and caregiver-rated generic (EuroQoL Instrument) and dementia-specific (Quality of Life-Alzheimer's Disease [Qol-AD]) scales. Patients reported a considerably higher HrQoL than their caregivers on the QoL-AD, EQ-5D, and EQ VAS (p <  0.001). Different dementia severity groups showed significantly worse results in HrQoL for patients with lower MMSE scores. The mean self-reported QoL-AD decreased from 32.3±5.7 in the group with the highest MMSE scores to 27.1±5.5 in patients with the lowest MMSE scores (p <  0.001). A considerably lower HrQoL was shown for institutionalized patients versus participants in outpatient settings (proxy-rated QoL-AD 19.7±4.6 versus 26.0±7.1, p <  0.001). Depressive symptoms (GDS), BPSD (NPI), and reduced functional capacity (ADCS-ADL) were evaluated for their impact on patients' HrQoL. Multivariate models explained between 22% and 54% of the variance in patients' HrQoL. To analyze the causative direction of the reported associations, further longitudinal studies should be conducted.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "Philipp He{\ss}mann and Greta Seeberg and Reese, {Jens Peter} and Judith Dams and Erika Baum and M{\"u}ller, {Matthias J} and Richard Dodel and Monika Balzer-Geldsetzer",
year = "2016",
doi = "10.3233/JAD-150835",
language = "English",
volume = "51",
pages = "545--561",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

RIS

TY - JOUR

T1 - Health-Related Quality of Life in Patients with Alzheimer's Disease in Different German Health Care Settings

AU - Heßmann, Philipp

AU - Seeberg, Greta

AU - Reese, Jens Peter

AU - Dams, Judith

AU - Baum, Erika

AU - Müller, Matthias J

AU - Dodel, Richard

AU - Balzer-Geldsetzer, Monika

PY - 2016

Y1 - 2016

N2 - The purpose of this study is to evaluate the health-related quality of life (HrQoL) of patients with Alzheimer's disease (AD) in different care settings (institutionalized versus community-dwelling) across all severity stages of dementia. Patients were consecutively recruited with their primary caregivers (123 inpatients and 272 outpatients), and the impact of patient-related parameters such as behavioral and psychological symptoms of dementia (BPSD) (Geriatric Depression Scale [GDS] and Neuropsychiatric Inventory [NPI]) and functional capacity (Alzheimer's Disease Cooperative Study-Activities of Daily Living [ADCS-ADL]) on HrQoL was analyzed. Patients' HrQoL was assessed using self-reported and caregiver-rated generic (EuroQoL Instrument) and dementia-specific (Quality of Life-Alzheimer's Disease [Qol-AD]) scales. Patients reported a considerably higher HrQoL than their caregivers on the QoL-AD, EQ-5D, and EQ VAS (p <  0.001). Different dementia severity groups showed significantly worse results in HrQoL for patients with lower MMSE scores. The mean self-reported QoL-AD decreased from 32.3±5.7 in the group with the highest MMSE scores to 27.1±5.5 in patients with the lowest MMSE scores (p <  0.001). A considerably lower HrQoL was shown for institutionalized patients versus participants in outpatient settings (proxy-rated QoL-AD 19.7±4.6 versus 26.0±7.1, p <  0.001). Depressive symptoms (GDS), BPSD (NPI), and reduced functional capacity (ADCS-ADL) were evaluated for their impact on patients' HrQoL. Multivariate models explained between 22% and 54% of the variance in patients' HrQoL. To analyze the causative direction of the reported associations, further longitudinal studies should be conducted.

AB - The purpose of this study is to evaluate the health-related quality of life (HrQoL) of patients with Alzheimer's disease (AD) in different care settings (institutionalized versus community-dwelling) across all severity stages of dementia. Patients were consecutively recruited with their primary caregivers (123 inpatients and 272 outpatients), and the impact of patient-related parameters such as behavioral and psychological symptoms of dementia (BPSD) (Geriatric Depression Scale [GDS] and Neuropsychiatric Inventory [NPI]) and functional capacity (Alzheimer's Disease Cooperative Study-Activities of Daily Living [ADCS-ADL]) on HrQoL was analyzed. Patients' HrQoL was assessed using self-reported and caregiver-rated generic (EuroQoL Instrument) and dementia-specific (Quality of Life-Alzheimer's Disease [Qol-AD]) scales. Patients reported a considerably higher HrQoL than their caregivers on the QoL-AD, EQ-5D, and EQ VAS (p <  0.001). Different dementia severity groups showed significantly worse results in HrQoL for patients with lower MMSE scores. The mean self-reported QoL-AD decreased from 32.3±5.7 in the group with the highest MMSE scores to 27.1±5.5 in patients with the lowest MMSE scores (p <  0.001). A considerably lower HrQoL was shown for institutionalized patients versus participants in outpatient settings (proxy-rated QoL-AD 19.7±4.6 versus 26.0±7.1, p <  0.001). Depressive symptoms (GDS), BPSD (NPI), and reduced functional capacity (ADCS-ADL) were evaluated for their impact on patients' HrQoL. Multivariate models explained between 22% and 54% of the variance in patients' HrQoL. To analyze the causative direction of the reported associations, further longitudinal studies should be conducted.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.3233/JAD-150835

DO - 10.3233/JAD-150835

M3 - SCORING: Journal article

C2 - 26890754

VL - 51

SP - 545

EP - 561

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 2

ER -