Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis
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Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis. / Pocock, Stuart; Brieger, David B; Owen, Ruth; Chen, Jiyan; Cohen, Mauricio G; Goodman, Shaun; Granger, Christopher B; Nicolau, José C; Simon, Tabassome; Westermann, Dirk; Yasuda, Satoshi; Hedman, Katarina; Mellström, Carl; Andersson Sundell, Karolina; Grieve, Richard.
In: OPEN HEART, Vol. 8, No. 1, e001499, 02.2021.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis
AU - Pocock, Stuart
AU - Brieger, David B
AU - Owen, Ruth
AU - Chen, Jiyan
AU - Cohen, Mauricio G
AU - Goodman, Shaun
AU - Granger, Christopher B
AU - Nicolau, José C
AU - Simon, Tabassome
AU - Westermann, Dirk
AU - Yasuda, Satoshi
AU - Hedman, Katarina
AU - Mellström, Carl
AU - Andersson Sundell, Karolina
AU - Grieve, Richard
N1 - © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/2
Y1 - 2021/2
N2 - OBJECTIVE: To assess associations of health-related quality of life (HRQoL) with patient profile, resource use, cardiovascular (CV) events and mortality in stable patients post-myocardial infarction (MI).METHODS: The global, prospective, observational TIGRIS Study enrolled 9126 patients 1-3 years post-MI. HRQoL was assessed at enrolment and 6-month intervals using the patient-reported EuroQol-5 dimension (EQ-5D) questionnaire, with scores anchored at 0 (worst possible) and 1 (perfect health). Resource use, CV events and mortality were recorded during 2-years' follow-up. Regression models estimated the associations of index score at enrolment with patient characteristics, resource use, CV events and mortality over 2-years' follow-up.RESULTS: Among 8978 patients who completed the EQ-5D questionnaire, 52% reported 'some' or 'severe' problems on one or more health dimensions. Factors associated with a lower index score were: female sex, older age, obesity, smoking, higher heart rate, less formal education, presence of comorbidity (eg, angina, stroke), emergency room visit in the previous 6 months and non-ST-elevation MI as the index event. Compared with an index score of 1 at enrolment, a lower index score was associated with higher risk of all-cause death, with an adjusted rate ratio of 3.09 (95% CI 2.20 to 4.31), and of a CV event, with a rate ratio of 2.31 (95% CI 1.76 to 3.03). Patients with lower index score at enrolment had almost two times as many hospitalisations over 2-years' follow-up.CONCLUSIONS: Clinicians managing patients post-acute coronary syndrome should recognise that a poorer HRQoL is clearly linked to risk of hospitalisations, major CV events and death.TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT01866904) (https://clinicaltrials.gov).
AB - OBJECTIVE: To assess associations of health-related quality of life (HRQoL) with patient profile, resource use, cardiovascular (CV) events and mortality in stable patients post-myocardial infarction (MI).METHODS: The global, prospective, observational TIGRIS Study enrolled 9126 patients 1-3 years post-MI. HRQoL was assessed at enrolment and 6-month intervals using the patient-reported EuroQol-5 dimension (EQ-5D) questionnaire, with scores anchored at 0 (worst possible) and 1 (perfect health). Resource use, CV events and mortality were recorded during 2-years' follow-up. Regression models estimated the associations of index score at enrolment with patient characteristics, resource use, CV events and mortality over 2-years' follow-up.RESULTS: Among 8978 patients who completed the EQ-5D questionnaire, 52% reported 'some' or 'severe' problems on one or more health dimensions. Factors associated with a lower index score were: female sex, older age, obesity, smoking, higher heart rate, less formal education, presence of comorbidity (eg, angina, stroke), emergency room visit in the previous 6 months and non-ST-elevation MI as the index event. Compared with an index score of 1 at enrolment, a lower index score was associated with higher risk of all-cause death, with an adjusted rate ratio of 3.09 (95% CI 2.20 to 4.31), and of a CV event, with a rate ratio of 2.31 (95% CI 1.76 to 3.03). Patients with lower index score at enrolment had almost two times as many hospitalisations over 2-years' follow-up.CONCLUSIONS: Clinicians managing patients post-acute coronary syndrome should recognise that a poorer HRQoL is clearly linked to risk of hospitalisations, major CV events and death.TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT01866904) (https://clinicaltrials.gov).
KW - Aged
KW - Aged, 80 and over
KW - Electrocardiography
KW - Female
KW - Follow-Up Studies
KW - Health Status
KW - Hospitalization
KW - Humans
KW - Male
KW - Middle Aged
KW - Myocardial Infarction/diagnosis
KW - Prognosis
KW - Prospective Studies
KW - Quality of Life
KW - Registries
KW - Surveys and Questionnaires
KW - Time Factors
U2 - 10.1136/openhrt-2020-001499
DO - 10.1136/openhrt-2020-001499
M3 - SCORING: Journal article
C2 - 33563776
VL - 8
JO - OPEN HEART
JF - OPEN HEART
SN - 2053-3624
IS - 1
M1 - e001499
ER -
