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Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies

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Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies. / Leon, David A; Shkolnikov, Vladimir M; Borinskaya, Svetlana; Casas, Juan-Pablo; Evans, Alun; Gil, Artyom; Kee, Frank; Kiryanov, Nikolay; McKee, Martin; O'Doherty, Mark G; Ploubidis, George B; Polikina, Olga; Vassiliev, Maxim; Blankenberg, Stefan; Watkins, Hugh.

In: EUR J EPIDEMIOL, Vol. 28, No. 5, 05.2013, p. 393-404.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Leon, DA, Shkolnikov, VM, Borinskaya, S, Casas, J-P, Evans, A, Gil, A, Kee, F, Kiryanov, N, McKee, M, O'Doherty, MG, Ploubidis, GB, Polikina, O, Vassiliev, M, Blankenberg, S & Watkins, H 2013, 'Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies', EUR J EPIDEMIOL, vol. 28, no. 5, pp. 393-404. https://doi.org/10.1007/s10654-013-9808-9

APA

Leon, D. A., Shkolnikov, V. M., Borinskaya, S., Casas, J-P., Evans, A., Gil, A., Kee, F., Kiryanov, N., McKee, M., O'Doherty, M. G., Ploubidis, G. B., Polikina, O., Vassiliev, M., Blankenberg, S., & Watkins, H. (2013). Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies. EUR J EPIDEMIOL, 28(5), 393-404. https://doi.org/10.1007/s10654-013-9808-9

Vancouver

Leon DA, Shkolnikov VM, Borinskaya S, Casas J-P, Evans A, Gil A et al. Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies. EUR J EPIDEMIOL. 2013 May;28(5):393-404. https://doi.org/10.1007/s10654-013-9808-9

Bibtex

@article{d44d92d4b6b5425cb8f70a153de43abc,
title = "Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies",
abstract = "Russia has very high mortality from cardiovascular disease (CVD), with evidence that heavy drinking may play a role. To throw further light on this association we have studied the association of alcohol with predictors of CVD risk including B-type natriuretic peptide (BNP). Levels of BNP increase primarily in response to abnormal cardiac chamber wall stretch which can occur both as a result of atherosclerosis as well as due to other types of damage to the myocardium. No previous population-based studies have investigated the association with alcohol. We analysed cross-sectional data on drinking behaviour in 993 men aged 25-60 years from the Izhevsk Family Study 2 (IFS2), conducted in the Russian city of Izhevsk in 2008-2009. Relative to non-drinkers, men who drank hazardously had an odds ratio (OR) of being in the top 20 % of the BNP distribution of 4.66 (95 % CI 2.13, 10.19) adjusted for age, obesity, waist-hip ratio, and smoking. Further adjustment for class of hypertension resulted in only slight attenuation of the effect, suggesting that this effect was not secondary to the influence of alcohol on blood pressure. In contrast hazardous drinking was associated with markedly raised ApoA1 and HDL cholesterol levels, but had little impact on levels of ApoB and LDL cholesterol. Similar but less pronounced associations were found in the Belfast (UK) component of the PRIME study conducted in 1991. These findings suggest that the association of heavy drinking with increased risk of cardiovascular disease may be partly due to alcohol-induced non-atherosclerotic damage to the myocardium.",
keywords = "Adult, Alcohol Drinking/adverse effects, Apolipoprotein A-I/blood, Apolipoproteins B/blood, Blood Pressure, Cardiovascular Diseases/blood, Cholesterol, HDL/blood, Cholesterol, LDL/blood, Cross-Sectional Studies, Humans, Logistic Models, Male, Middle Aged, Natriuretic Peptide, Brain/blood, Population Surveillance, Risk Factors, Russia/epidemiology, Socioeconomic Factors, Surveys and Questionnaires",
author = "Leon, {David A} and Shkolnikov, {Vladimir M} and Svetlana Borinskaya and Juan-Pablo Casas and Alun Evans and Artyom Gil and Frank Kee and Nikolay Kiryanov and Martin McKee and O'Doherty, {Mark G} and Ploubidis, {George B} and Olga Polikina and Maxim Vassiliev and Stefan Blankenberg and Hugh Watkins",
year = "2013",
month = may,
doi = "10.1007/s10654-013-9808-9",
language = "English",
volume = "28",
pages = "393--404",
journal = "EUR J EPIDEMIOL",
issn = "0393-2990",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Hazardous alcohol consumption is associated with increased levels of B-type natriuretic peptide: evidence from two population-based studies

AU - Leon, David A

AU - Shkolnikov, Vladimir M

AU - Borinskaya, Svetlana

AU - Casas, Juan-Pablo

AU - Evans, Alun

AU - Gil, Artyom

AU - Kee, Frank

AU - Kiryanov, Nikolay

AU - McKee, Martin

AU - O'Doherty, Mark G

AU - Ploubidis, George B

AU - Polikina, Olga

AU - Vassiliev, Maxim

AU - Blankenberg, Stefan

AU - Watkins, Hugh

PY - 2013/5

Y1 - 2013/5

N2 - Russia has very high mortality from cardiovascular disease (CVD), with evidence that heavy drinking may play a role. To throw further light on this association we have studied the association of alcohol with predictors of CVD risk including B-type natriuretic peptide (BNP). Levels of BNP increase primarily in response to abnormal cardiac chamber wall stretch which can occur both as a result of atherosclerosis as well as due to other types of damage to the myocardium. No previous population-based studies have investigated the association with alcohol. We analysed cross-sectional data on drinking behaviour in 993 men aged 25-60 years from the Izhevsk Family Study 2 (IFS2), conducted in the Russian city of Izhevsk in 2008-2009. Relative to non-drinkers, men who drank hazardously had an odds ratio (OR) of being in the top 20 % of the BNP distribution of 4.66 (95 % CI 2.13, 10.19) adjusted for age, obesity, waist-hip ratio, and smoking. Further adjustment for class of hypertension resulted in only slight attenuation of the effect, suggesting that this effect was not secondary to the influence of alcohol on blood pressure. In contrast hazardous drinking was associated with markedly raised ApoA1 and HDL cholesterol levels, but had little impact on levels of ApoB and LDL cholesterol. Similar but less pronounced associations were found in the Belfast (UK) component of the PRIME study conducted in 1991. These findings suggest that the association of heavy drinking with increased risk of cardiovascular disease may be partly due to alcohol-induced non-atherosclerotic damage to the myocardium.

AB - Russia has very high mortality from cardiovascular disease (CVD), with evidence that heavy drinking may play a role. To throw further light on this association we have studied the association of alcohol with predictors of CVD risk including B-type natriuretic peptide (BNP). Levels of BNP increase primarily in response to abnormal cardiac chamber wall stretch which can occur both as a result of atherosclerosis as well as due to other types of damage to the myocardium. No previous population-based studies have investigated the association with alcohol. We analysed cross-sectional data on drinking behaviour in 993 men aged 25-60 years from the Izhevsk Family Study 2 (IFS2), conducted in the Russian city of Izhevsk in 2008-2009. Relative to non-drinkers, men who drank hazardously had an odds ratio (OR) of being in the top 20 % of the BNP distribution of 4.66 (95 % CI 2.13, 10.19) adjusted for age, obesity, waist-hip ratio, and smoking. Further adjustment for class of hypertension resulted in only slight attenuation of the effect, suggesting that this effect was not secondary to the influence of alcohol on blood pressure. In contrast hazardous drinking was associated with markedly raised ApoA1 and HDL cholesterol levels, but had little impact on levels of ApoB and LDL cholesterol. Similar but less pronounced associations were found in the Belfast (UK) component of the PRIME study conducted in 1991. These findings suggest that the association of heavy drinking with increased risk of cardiovascular disease may be partly due to alcohol-induced non-atherosclerotic damage to the myocardium.

KW - Adult

KW - Alcohol Drinking/adverse effects

KW - Apolipoprotein A-I/blood

KW - Apolipoproteins B/blood

KW - Blood Pressure

KW - Cardiovascular Diseases/blood

KW - Cholesterol, HDL/blood

KW - Cholesterol, LDL/blood

KW - Cross-Sectional Studies

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Natriuretic Peptide, Brain/blood

KW - Population Surveillance

KW - Risk Factors

KW - Russia/epidemiology

KW - Socioeconomic Factors

KW - Surveys and Questionnaires

U2 - 10.1007/s10654-013-9808-9

DO - 10.1007/s10654-013-9808-9

M3 - SCORING: Journal article

C2 - 23645505

VL - 28

SP - 393

EP - 404

JO - EUR J EPIDEMIOL

JF - EUR J EPIDEMIOL

SN - 0393-2990

IS - 5

ER -