Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: A report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT
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Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: A report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT. / Sureda, Anna; Carpenter, Paul A; Bacigalupo, Andrea; Bhatt, Vijaya Raj; de la Fuente, Josu; Ho, Aloysius; Kean, Leslie; Lee, Jong Wook; Sánchez-Ortega, Isabel; Savani, Bipin N; Schetelig, Johannes; Stadtmauer, Edward A; Takahashi, Yoshiyuki; Atsuta, Yoshiko; Koreth, John; Kröger, Nicolaus; Ljungman, Per; Okamoto, Shinichiro; Popat, Uday; Soiffer, Robert; Stefanski, Heather E; Kharfan-Dabaja, Mohamed A.
In: BONE MARROW TRANSPL, Vol. 59, No. 6, 06.2024, p. 832-837.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Harmonizing definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism in allogeneic hematopoietic cell transplantation: A report on behalf of the EBMT, ASTCT, CIBMTR, and APBMT
AU - Sureda, Anna
AU - Carpenter, Paul A
AU - Bacigalupo, Andrea
AU - Bhatt, Vijaya Raj
AU - de la Fuente, Josu
AU - Ho, Aloysius
AU - Kean, Leslie
AU - Lee, Jong Wook
AU - Sánchez-Ortega, Isabel
AU - Savani, Bipin N
AU - Schetelig, Johannes
AU - Stadtmauer, Edward A
AU - Takahashi, Yoshiyuki
AU - Atsuta, Yoshiko
AU - Koreth, John
AU - Kröger, Nicolaus
AU - Ljungman, Per
AU - Okamoto, Shinichiro
AU - Popat, Uday
AU - Soiffer, Robert
AU - Stefanski, Heather E
AU - Kharfan-Dabaja, Mohamed A
N1 - © 2024. The Author(s).
PY - 2024/6
Y1 - 2024/6
N2 - Despite emergence of novel therapies to treat hematologic malignancies, allogeneic hematopoietic cell transplantation (allo-HCT) remains an essential treatment modality capable of curing these diseases. Allo-HCT has been also shown to be curative in benign hematologic disorders such as aplastic anemia, sickle cell disease, and thalassemia, among others. Recently, the American Society for Transplantation and Cellular Therapy (ASTCT) published standardized definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism. To attempt broader international consensus, a panel of adult and pediatric physician transplant experts was assembled from European Society for Blood and Marrow Transplantation (EBMT), ASTCT, the Center for International Blood and Marrow Transplant Research (CIBMTR), and Asia-Pacific Blood and Marrow Transplantation (APBMT). Consensus was defined as ≥70% of voting members strongly agreeing or somewhat agreeing with a definition. With few exceptions, there was a consensus to endorse the prior ASTCT definitions. Importantly, we revised existing EBMT and CIBMTR data collection forms to align with these harmonized definitions that will facilitate research and international collaboration among transplant researchers and across transplant registries.
AB - Despite emergence of novel therapies to treat hematologic malignancies, allogeneic hematopoietic cell transplantation (allo-HCT) remains an essential treatment modality capable of curing these diseases. Allo-HCT has been also shown to be curative in benign hematologic disorders such as aplastic anemia, sickle cell disease, and thalassemia, among others. Recently, the American Society for Transplantation and Cellular Therapy (ASTCT) published standardized definitions for hematopoietic recovery, graft rejection, graft failure, poor graft function, and donor chimerism. To attempt broader international consensus, a panel of adult and pediatric physician transplant experts was assembled from European Society for Blood and Marrow Transplantation (EBMT), ASTCT, the Center for International Blood and Marrow Transplant Research (CIBMTR), and Asia-Pacific Blood and Marrow Transplantation (APBMT). Consensus was defined as ≥70% of voting members strongly agreeing or somewhat agreeing with a definition. With few exceptions, there was a consensus to endorse the prior ASTCT definitions. Importantly, we revised existing EBMT and CIBMTR data collection forms to align with these harmonized definitions that will facilitate research and international collaboration among transplant researchers and across transplant registries.
U2 - 10.1038/s41409-024-02251-0
DO - 10.1038/s41409-024-02251-0
M3 - SCORING: Journal article
C2 - 38443706
VL - 59
SP - 832
EP - 837
JO - BONE MARROW TRANSPL
JF - BONE MARROW TRANSPL
SN - 0268-3369
IS - 6
ER -