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Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms

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Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms. / Dettenborn-Betz, Lucia; Hinkelmann, Kim; Muhtz, Christoph; Gao, Wei; Wingenfeld, Katja; Spitzer, Carsten; Moritz, Steffen; Kirschbaum, Clemens; Otte, Christian.

In: PSYCHONEUROENDOCRINO, Vol. 38, No. 10, 01.10.2013, p. 2373-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Dettenborn-Betz, L, Hinkelmann, K, Muhtz, C, Gao, W, Wingenfeld, K, Spitzer, C, Moritz, S, Kirschbaum, C & Otte, C 2013, 'Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms', PSYCHONEUROENDOCRINO, vol. 38, no. 10, pp. 2373-7. https://doi.org/10.1016/j.psyneuen.2013.03.011

APA

Dettenborn-Betz, L., Hinkelmann, K., Muhtz, C., Gao, W., Wingenfeld, K., Spitzer, C., Moritz, S., Kirschbaum, C., & Otte, C. (2013). Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms. PSYCHONEUROENDOCRINO, 38(10), 2373-7. https://doi.org/10.1016/j.psyneuen.2013.03.011

Vancouver

Dettenborn-Betz L, Hinkelmann K, Muhtz C, Gao W, Wingenfeld K, Spitzer C et al. Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms. PSYCHONEUROENDOCRINO. 2013 Oct 1;38(10):2373-7. https://doi.org/10.1016/j.psyneuen.2013.03.011

Bibtex

@article{38c738f2894b43f8a8b88443f68021de,
title = "Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms",
abstract = "BACKGROUND: Testosterone binds to androgen receptors, which can be found abundantly in the hippocampus. Associations between testosterone levels and visuospatial memory have been reported, albeit with inconsistent results. Previous studies have used point sampling of testosterone levels (blood, saliva) rather than long-term secretion measures. Hair analysis for steroids allows for retrospective ascertainment of cumulative steroid measures over several months. We examined hair testosterone and its association with verbal and visuospatial memory in middle-aged men and women with and without major depression.METHODS: We examined a total of 73 middle-aged individuals (35 depressed patients, and 38 age-, sex- and education-matched healthy subjects). We tested verbal (Auditory Verbal Learning Task) and visuospatial (Rey figure) memory and measured testosterone in the hair by liquid chromatography tandem mass spectrometry.RESULTS: Hair testosterone levels did not differ between patients and controls (mean 1.35pg/mg vs. 1.40pg/mg, SD 0.61 and 0.80, respectively). In men (n=24) but not women (n=49), hair testosterone was associated with visuospatial memory in a multiple regression analysis after controlling for age, education, body mass index, and depression (adjusted R(2)=0.56).CONCLUSIONS: With the new method of testosterone measurement in hair allowing for long-term cumulative ascertainment of testosterone secretion, we extend recent results of a male-specific role for testosterone in visuospatial memory.",
keywords = "Adult, Depression, Female, Hair, Humans, Male, Memory, Middle Aged, Neuropsychological Tests, Pattern Recognition, Visual, Space Perception, Tandem Mass Spectrometry, Testosterone, Verbal Learning",
author = "Lucia Dettenborn-Betz and Kim Hinkelmann and Christoph Muhtz and Wei Gao and Katja Wingenfeld and Carsten Spitzer and Steffen Moritz and Clemens Kirschbaum and Christian Otte",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = oct,
day = "1",
doi = "10.1016/j.psyneuen.2013.03.011",
language = "English",
volume = "38",
pages = "2373--7",
journal = "PSYCHONEUROENDOCRINO",
issn = "0306-4530",
publisher = "Elsevier Limited",
number = "10",

}

RIS

TY - JOUR

T1 - Hair testosterone and visuospatial memory in middle-aged men and women with and without depressive symptoms

AU - Dettenborn-Betz, Lucia

AU - Hinkelmann, Kim

AU - Muhtz, Christoph

AU - Gao, Wei

AU - Wingenfeld, Katja

AU - Spitzer, Carsten

AU - Moritz, Steffen

AU - Kirschbaum, Clemens

AU - Otte, Christian

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/10/1

Y1 - 2013/10/1

N2 - BACKGROUND: Testosterone binds to androgen receptors, which can be found abundantly in the hippocampus. Associations between testosterone levels and visuospatial memory have been reported, albeit with inconsistent results. Previous studies have used point sampling of testosterone levels (blood, saliva) rather than long-term secretion measures. Hair analysis for steroids allows for retrospective ascertainment of cumulative steroid measures over several months. We examined hair testosterone and its association with verbal and visuospatial memory in middle-aged men and women with and without major depression.METHODS: We examined a total of 73 middle-aged individuals (35 depressed patients, and 38 age-, sex- and education-matched healthy subjects). We tested verbal (Auditory Verbal Learning Task) and visuospatial (Rey figure) memory and measured testosterone in the hair by liquid chromatography tandem mass spectrometry.RESULTS: Hair testosterone levels did not differ between patients and controls (mean 1.35pg/mg vs. 1.40pg/mg, SD 0.61 and 0.80, respectively). In men (n=24) but not women (n=49), hair testosterone was associated with visuospatial memory in a multiple regression analysis after controlling for age, education, body mass index, and depression (adjusted R(2)=0.56).CONCLUSIONS: With the new method of testosterone measurement in hair allowing for long-term cumulative ascertainment of testosterone secretion, we extend recent results of a male-specific role for testosterone in visuospatial memory.

AB - BACKGROUND: Testosterone binds to androgen receptors, which can be found abundantly in the hippocampus. Associations between testosterone levels and visuospatial memory have been reported, albeit with inconsistent results. Previous studies have used point sampling of testosterone levels (blood, saliva) rather than long-term secretion measures. Hair analysis for steroids allows for retrospective ascertainment of cumulative steroid measures over several months. We examined hair testosterone and its association with verbal and visuospatial memory in middle-aged men and women with and without major depression.METHODS: We examined a total of 73 middle-aged individuals (35 depressed patients, and 38 age-, sex- and education-matched healthy subjects). We tested verbal (Auditory Verbal Learning Task) and visuospatial (Rey figure) memory and measured testosterone in the hair by liquid chromatography tandem mass spectrometry.RESULTS: Hair testosterone levels did not differ between patients and controls (mean 1.35pg/mg vs. 1.40pg/mg, SD 0.61 and 0.80, respectively). In men (n=24) but not women (n=49), hair testosterone was associated with visuospatial memory in a multiple regression analysis after controlling for age, education, body mass index, and depression (adjusted R(2)=0.56).CONCLUSIONS: With the new method of testosterone measurement in hair allowing for long-term cumulative ascertainment of testosterone secretion, we extend recent results of a male-specific role for testosterone in visuospatial memory.

KW - Adult

KW - Depression

KW - Female

KW - Hair

KW - Humans

KW - Male

KW - Memory

KW - Middle Aged

KW - Neuropsychological Tests

KW - Pattern Recognition, Visual

KW - Space Perception

KW - Tandem Mass Spectrometry

KW - Testosterone

KW - Verbal Learning

U2 - 10.1016/j.psyneuen.2013.03.011

DO - 10.1016/j.psyneuen.2013.03.011

M3 - SCORING: Journal article

C2 - 23602131

VL - 38

SP - 2373

EP - 2377

JO - PSYCHONEUROENDOCRINO

JF - PSYCHONEUROENDOCRINO

SN - 0306-4530

IS - 10

ER -