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Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour

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Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour. / Vashist, Yogesh K; Uzunoglu, Guentac; Cataldegirmen, Guelle; Kalinin, Viacheslar; Schurr, Paulus; Koenig, Alexandra M; Thieltges, Sabrina; Zehler, Oliver; Schneider, Claus; Izbicki, Jacob R; Yekebas, Emre F.

In: HISTOPATHOLOGY, Vol. 54, No. 3, 02.2009, p. 303-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vashist, YK, Uzunoglu, G, Cataldegirmen, G, Kalinin, V, Schurr, P, Koenig, AM, Thieltges, S, Zehler, O, Schneider, C, Izbicki, JR & Yekebas, EF 2009, 'Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour', HISTOPATHOLOGY, vol. 54, no. 3, pp. 303-8. https://doi.org/10.1111/j.1365-2559.2009.03221.x

APA

Vashist, Y. K., Uzunoglu, G., Cataldegirmen, G., Kalinin, V., Schurr, P., Koenig, A. M., Thieltges, S., Zehler, O., Schneider, C., Izbicki, J. R., & Yekebas, E. F. (2009). Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour. HISTOPATHOLOGY, 54(3), 303-8. https://doi.org/10.1111/j.1365-2559.2009.03221.x

Vancouver

Vashist YK, Uzunoglu G, Cataldegirmen G, Kalinin V, Schurr P, Koenig AM et al. Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour. HISTOPATHOLOGY. 2009 Feb;54(3):303-8. https://doi.org/10.1111/j.1365-2559.2009.03221.x

Bibtex

@article{d3b83a359e62446cbd9a120fd90baa25,
title = "Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour",
abstract = "AIMS: Gastrointestinal stromal tumours (GISTs) display genetic alterations on chromosome 22. GTn repeat (GTn) length polymorphism in the promoter of haeme oxygenase-1 gene (HMOX-1) is located on chromosome 22 and associated with malignant growth. The aim was to investigate the role of HMOX-1 promoter polymorphism in GIST patients.METHODS AND RESULTS: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival (P = 0.001).CONCLUSIONS: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST.",
keywords = "Biomarkers, Tumor, Female, Gastrointestinal Stromal Tumors, Heme Oxygenase-1, Humans, Male, Middle Aged, Polymorphism, Genetic, Promoter Regions, Genetic",
author = "Vashist, {Yogesh K} and Guentac Uzunoglu and Guelle Cataldegirmen and Viacheslar Kalinin and Paulus Schurr and Koenig, {Alexandra M} and Sabrina Thieltges and Oliver Zehler and Claus Schneider and Izbicki, {Jacob R} and Yekebas, {Emre F}",
year = "2009",
month = feb,
doi = "10.1111/j.1365-2559.2009.03221.x",
language = "English",
volume = "54",
pages = "303--8",
journal = "HISTOPATHOLOGY",
issn = "0309-0167",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour

AU - Vashist, Yogesh K

AU - Uzunoglu, Guentac

AU - Cataldegirmen, Guelle

AU - Kalinin, Viacheslar

AU - Schurr, Paulus

AU - Koenig, Alexandra M

AU - Thieltges, Sabrina

AU - Zehler, Oliver

AU - Schneider, Claus

AU - Izbicki, Jacob R

AU - Yekebas, Emre F

PY - 2009/2

Y1 - 2009/2

N2 - AIMS: Gastrointestinal stromal tumours (GISTs) display genetic alterations on chromosome 22. GTn repeat (GTn) length polymorphism in the promoter of haeme oxygenase-1 gene (HMOX-1) is located on chromosome 22 and associated with malignant growth. The aim was to investigate the role of HMOX-1 promoter polymorphism in GIST patients.METHODS AND RESULTS: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival (P = 0.001).CONCLUSIONS: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST.

AB - AIMS: Gastrointestinal stromal tumours (GISTs) display genetic alterations on chromosome 22. GTn repeat (GTn) length polymorphism in the promoter of haeme oxygenase-1 gene (HMOX-1) is located on chromosome 22 and associated with malignant growth. The aim was to investigate the role of HMOX-1 promoter polymorphism in GIST patients.METHODS AND RESULTS: Tumour and corresponding healthy tissue DNA of 44 patients who underwent surgical resection of GIST were analysed by polymerase chain reaction, capillary electrophoresis and DNA sequencing. GTn polymorphism was classified into short (S) and long (L) allele. There was no difference detected in GTn genotype between tumour and healthy tissue DNA. Short GTn allele (SGTn) was significantly associated with metastatic disease, higher tumour recurrence rates and high risk GIST (consensus criteria 2001). Furthermore, SGTn allele carriers had significantly shorter disease-free and overall survival (log rank test, P < 0.0001). On multivariate Cox regression analysis, GTn polymorphism was identified as an independent prognostic factor for survival (P = 0.001).CONCLUSIONS: HMOX-1 promoter GTn polymorphism is a potential prognostic marker and may help to allocate patients to different risk groups, customized therapy and follow-up. Haeme oxygenase-1 could represent an important candidate gene in the pathogenesis and growth of GIST.

KW - Biomarkers, Tumor

KW - Female

KW - Gastrointestinal Stromal Tumors

KW - Heme Oxygenase-1

KW - Humans

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Promoter Regions, Genetic

U2 - 10.1111/j.1365-2559.2009.03221.x

DO - 10.1111/j.1365-2559.2009.03221.x

M3 - SCORING: Journal article

C2 - 19236506

VL - 54

SP - 303

EP - 308

JO - HISTOPATHOLOGY

JF - HISTOPATHOLOGY

SN - 0309-0167

IS - 3

ER -