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H7N9 avian influenza virus infection in men is associated with testosterone depletion

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H7N9 avian influenza virus infection in men is associated with testosterone depletion. / Bai, Tian; Chen, Yongkun; Beck, Sebastian; Stanelle-Bertram, Stephanie; Mounogou, Nancy Kouassi; Chen, Tao; Dong, Jie; Schneider, Bettina; Jia, Tingting; Yang, Jing; Wang, Lijie; Meinhardt, Andreas; Zapf, Antonia; Kreienbrock, Lothar; Wang, Dayan; Shu, Yuelong; Gabriel, Gülsah.

In: NAT COMMUN, Vol. 13, No. 1, 6936, 14.11.2022.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bai, T, Chen, Y, Beck, S, Stanelle-Bertram, S, Mounogou, NK, Chen, T, Dong, J, Schneider, B, Jia, T, Yang, J, Wang, L, Meinhardt, A, Zapf, A, Kreienbrock, L, Wang, D, Shu, Y & Gabriel, G 2022, 'H7N9 avian influenza virus infection in men is associated with testosterone depletion', NAT COMMUN, vol. 13, no. 1, 6936. https://doi.org/10.1038/s41467-022-34500-5

APA

Bai, T., Chen, Y., Beck, S., Stanelle-Bertram, S., Mounogou, N. K., Chen, T., Dong, J., Schneider, B., Jia, T., Yang, J., Wang, L., Meinhardt, A., Zapf, A., Kreienbrock, L., Wang, D., Shu, Y., & Gabriel, G. (2022). H7N9 avian influenza virus infection in men is associated with testosterone depletion. NAT COMMUN, 13(1), [6936]. https://doi.org/10.1038/s41467-022-34500-5

Vancouver

Bai T, Chen Y, Beck S, Stanelle-Bertram S, Mounogou NK, Chen T et al. H7N9 avian influenza virus infection in men is associated with testosterone depletion. NAT COMMUN. 2022 Nov 14;13(1). 6936. https://doi.org/10.1038/s41467-022-34500-5

Bibtex

@article{36d2a3b2952942c785c599771398a304,
title = "H7N9 avian influenza virus infection in men is associated with testosterone depletion",
abstract = "Human infections with H7N9 avian influenza A virus that emerged in East China in 2013 and caused high morbidity rates were more frequently detected in men than in women over the last five epidemic waves. However, molecular markers associated with poor disease outcomes in men are still unknown. In this study, we systematically analysed sex hormone and cytokine levels in males and females with laboratory-confirmed H7N9 influenza in comparison to H7N9-negative control groups as well as laboratory-confirmed seasonal H1N1/H3N2 influenza cases (n = 369). Multivariable analyses reveal that H7N9-infected men present with considerably reduced testosterone levels associated with a poor outcome compared to non-infected controls. Regression analyses reveal that testosterone levels in H7N9-infected men are negatively associated with the levels of several pro-inflammatory cytokines, such as IL-6 and IL-15. To assess whether there is a causal relationship between low testosterone levels and avian H7N9 influenza infection, we used a mouse model. In male mice, we show that respiratory H7N9 infection leads to a high viral load and inflammatory cytokine response in the testes as well as a reduction in pre-infection plasma testosterone levels. Collectively, these findings suggest that monitoring sex hormone levels may support individualized management for patients with avian influenza infections.",
keywords = "Humans, Male, Female, Animals, Mice, Influenza in Birds, Influenza A Virus, H7N9 Subtype, Influenza, Human, Influenza A Virus, H1N1 Subtype, Influenza A Virus, H3N2 Subtype, Testosterone, Cytokines, China/epidemiology",
author = "Tian Bai and Yongkun Chen and Sebastian Beck and Stephanie Stanelle-Bertram and Mounogou, {Nancy Kouassi} and Tao Chen and Jie Dong and Bettina Schneider and Tingting Jia and Jing Yang and Lijie Wang and Andreas Meinhardt and Antonia Zapf and Lothar Kreienbrock and Dayan Wang and Yuelong Shu and G{\"u}lsah Gabriel",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = nov,
day = "14",
doi = "10.1038/s41467-022-34500-5",
language = "English",
volume = "13",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - H7N9 avian influenza virus infection in men is associated with testosterone depletion

AU - Bai, Tian

AU - Chen, Yongkun

AU - Beck, Sebastian

AU - Stanelle-Bertram, Stephanie

AU - Mounogou, Nancy Kouassi

AU - Chen, Tao

AU - Dong, Jie

AU - Schneider, Bettina

AU - Jia, Tingting

AU - Yang, Jing

AU - Wang, Lijie

AU - Meinhardt, Andreas

AU - Zapf, Antonia

AU - Kreienbrock, Lothar

AU - Wang, Dayan

AU - Shu, Yuelong

AU - Gabriel, Gülsah

N1 - © 2022. The Author(s).

PY - 2022/11/14

Y1 - 2022/11/14

N2 - Human infections with H7N9 avian influenza A virus that emerged in East China in 2013 and caused high morbidity rates were more frequently detected in men than in women over the last five epidemic waves. However, molecular markers associated with poor disease outcomes in men are still unknown. In this study, we systematically analysed sex hormone and cytokine levels in males and females with laboratory-confirmed H7N9 influenza in comparison to H7N9-negative control groups as well as laboratory-confirmed seasonal H1N1/H3N2 influenza cases (n = 369). Multivariable analyses reveal that H7N9-infected men present with considerably reduced testosterone levels associated with a poor outcome compared to non-infected controls. Regression analyses reveal that testosterone levels in H7N9-infected men are negatively associated with the levels of several pro-inflammatory cytokines, such as IL-6 and IL-15. To assess whether there is a causal relationship between low testosterone levels and avian H7N9 influenza infection, we used a mouse model. In male mice, we show that respiratory H7N9 infection leads to a high viral load and inflammatory cytokine response in the testes as well as a reduction in pre-infection plasma testosterone levels. Collectively, these findings suggest that monitoring sex hormone levels may support individualized management for patients with avian influenza infections.

AB - Human infections with H7N9 avian influenza A virus that emerged in East China in 2013 and caused high morbidity rates were more frequently detected in men than in women over the last five epidemic waves. However, molecular markers associated with poor disease outcomes in men are still unknown. In this study, we systematically analysed sex hormone and cytokine levels in males and females with laboratory-confirmed H7N9 influenza in comparison to H7N9-negative control groups as well as laboratory-confirmed seasonal H1N1/H3N2 influenza cases (n = 369). Multivariable analyses reveal that H7N9-infected men present with considerably reduced testosterone levels associated with a poor outcome compared to non-infected controls. Regression analyses reveal that testosterone levels in H7N9-infected men are negatively associated with the levels of several pro-inflammatory cytokines, such as IL-6 and IL-15. To assess whether there is a causal relationship between low testosterone levels and avian H7N9 influenza infection, we used a mouse model. In male mice, we show that respiratory H7N9 infection leads to a high viral load and inflammatory cytokine response in the testes as well as a reduction in pre-infection plasma testosterone levels. Collectively, these findings suggest that monitoring sex hormone levels may support individualized management for patients with avian influenza infections.

KW - Humans

KW - Male

KW - Female

KW - Animals

KW - Mice

KW - Influenza in Birds

KW - Influenza A Virus, H7N9 Subtype

KW - Influenza, Human

KW - Influenza A Virus, H1N1 Subtype

KW - Influenza A Virus, H3N2 Subtype

KW - Testosterone

KW - Cytokines

KW - China/epidemiology

U2 - 10.1038/s41467-022-34500-5

DO - 10.1038/s41467-022-34500-5

M3 - SCORING: Journal article

C2 - 36376288

VL - 13

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 6936

ER -