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Gut microbiome and atrial fibrillation-results from a large population-based study

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Gut microbiome and atrial fibrillation-results from a large population-based study. / Palmu, Joonatan; Börschel, Christin S; Ortega-Alonso, Alfredo; Markó, Lajos; Inouye, Michael; Jousilahti, Pekka; Salido, Rodolfo A; Sanders, Karenina; Brennan, Caitriona; Humphrey, Gregory C; Sanders, Jon G; Gutmann, Friederike; Linz, Dominik; Salomaa, Veikko; Havulinna, Aki S; Forslund, Sofia K; Knight, Rob; Lahti, Leo; Niiranen, Teemu; Schnabel, Renate B.

In: EBIOMEDICINE, Vol. 91, 05.2023, p. 104583.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Palmu, J, Börschel, CS, Ortega-Alonso, A, Markó, L, Inouye, M, Jousilahti, P, Salido, RA, Sanders, K, Brennan, C, Humphrey, GC, Sanders, JG, Gutmann, F, Linz, D, Salomaa, V, Havulinna, AS, Forslund, SK, Knight, R, Lahti, L, Niiranen, T & Schnabel, RB 2023, 'Gut microbiome and atrial fibrillation-results from a large population-based study', EBIOMEDICINE, vol. 91, pp. 104583. https://doi.org/10.1016/j.ebiom.2023.104583

APA

Palmu, J., Börschel, C. S., Ortega-Alonso, A., Markó, L., Inouye, M., Jousilahti, P., Salido, R. A., Sanders, K., Brennan, C., Humphrey, G. C., Sanders, J. G., Gutmann, F., Linz, D., Salomaa, V., Havulinna, A. S., Forslund, S. K., Knight, R., Lahti, L., Niiranen, T., & Schnabel, R. B. (2023). Gut microbiome and atrial fibrillation-results from a large population-based study. EBIOMEDICINE, 91, 104583. https://doi.org/10.1016/j.ebiom.2023.104583

Vancouver

Palmu J, Börschel CS, Ortega-Alonso A, Markó L, Inouye M, Jousilahti P et al. Gut microbiome and atrial fibrillation-results from a large population-based study. EBIOMEDICINE. 2023 May;91:104583. https://doi.org/10.1016/j.ebiom.2023.104583

Bibtex

@article{64db8fc52bef45ff967b126f757054ab,
title = "Gut microbiome and atrial fibrillation-results from a large population-based study",
abstract = "BACKGROUND: Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown.METHODS: We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case-control cohort of 138 individuals in Hamburg, Germany.FINDINGS: Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P < 0.05. Both prevalent and incident AF were associated with the genera Enorma and Bifidobacterium (FDR-corrected P < 0.001). AF was not significantly associated with bacterial diversity measures. Seventy-five percent of top genera (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) in Cox regression analyses showed a consistent direction of shifted abundance in an independent AF case-control cohort that was used for replication.INTERPRETATION: Our findings establish the basis for the use of microbiome profiles in AF risk prediction. However, extensive research is still warranted before microbiome sequencing can be used for prevention and targeted treatment of AF.FUNDING: This study was funded by European Research Council, German Ministry of Research and Education, Academy of Finland, Finnish Medical Foundation, and the Finnish Foundation for Cardiovascular Research, the Emil Aaltonen Foundation, and the Paavo Nurmi Foundation.",
keywords = "Humans, Atrial Fibrillation/etiology, Gastrointestinal Microbiome, Heart, Bacteria/genetics, Aging, Incidence",
author = "Joonatan Palmu and B{\"o}rschel, {Christin S} and Alfredo Ortega-Alonso and Lajos Mark{\'o} and Michael Inouye and Pekka Jousilahti and Salido, {Rodolfo A} and Karenina Sanders and Caitriona Brennan and Humphrey, {Gregory C} and Sanders, {Jon G} and Friederike Gutmann and Dominik Linz and Veikko Salomaa and Havulinna, {Aki S} and Forslund, {Sofia K} and Rob Knight and Leo Lahti and Teemu Niiranen and Schnabel, {Renate B}",
note = "Copyright {\textcopyright} 2023 The Author(s). Published by Elsevier B.V. All rights reserved.",
year = "2023",
month = may,
doi = "10.1016/j.ebiom.2023.104583",
language = "English",
volume = "91",
pages = "104583",
journal = "EBIOMEDICINE",
issn = "2352-3964",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Gut microbiome and atrial fibrillation-results from a large population-based study

AU - Palmu, Joonatan

AU - Börschel, Christin S

AU - Ortega-Alonso, Alfredo

AU - Markó, Lajos

AU - Inouye, Michael

AU - Jousilahti, Pekka

AU - Salido, Rodolfo A

AU - Sanders, Karenina

AU - Brennan, Caitriona

AU - Humphrey, Gregory C

AU - Sanders, Jon G

AU - Gutmann, Friederike

AU - Linz, Dominik

AU - Salomaa, Veikko

AU - Havulinna, Aki S

AU - Forslund, Sofia K

AU - Knight, Rob

AU - Lahti, Leo

AU - Niiranen, Teemu

AU - Schnabel, Renate B

N1 - Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.

PY - 2023/5

Y1 - 2023/5

N2 - BACKGROUND: Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown.METHODS: We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case-control cohort of 138 individuals in Hamburg, Germany.FINDINGS: Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P < 0.05. Both prevalent and incident AF were associated with the genera Enorma and Bifidobacterium (FDR-corrected P < 0.001). AF was not significantly associated with bacterial diversity measures. Seventy-five percent of top genera (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) in Cox regression analyses showed a consistent direction of shifted abundance in an independent AF case-control cohort that was used for replication.INTERPRETATION: Our findings establish the basis for the use of microbiome profiles in AF risk prediction. However, extensive research is still warranted before microbiome sequencing can be used for prevention and targeted treatment of AF.FUNDING: This study was funded by European Research Council, German Ministry of Research and Education, Academy of Finland, Finnish Medical Foundation, and the Finnish Foundation for Cardiovascular Research, the Emil Aaltonen Foundation, and the Paavo Nurmi Foundation.

AB - BACKGROUND: Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown.METHODS: We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case-control cohort of 138 individuals in Hamburg, Germany.FINDINGS: Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 539) over a median follow-up of 15 years was associated with eight microbial genera with false discovery rate (FDR)-corrected P < 0.05. Both prevalent and incident AF were associated with the genera Enorma and Bifidobacterium (FDR-corrected P < 0.001). AF was not significantly associated with bacterial diversity measures. Seventy-five percent of top genera (Enorma, Paraprevotella, Odoribacter, Collinsella, Barnesiella, Alistipes) in Cox regression analyses showed a consistent direction of shifted abundance in an independent AF case-control cohort that was used for replication.INTERPRETATION: Our findings establish the basis for the use of microbiome profiles in AF risk prediction. However, extensive research is still warranted before microbiome sequencing can be used for prevention and targeted treatment of AF.FUNDING: This study was funded by European Research Council, German Ministry of Research and Education, Academy of Finland, Finnish Medical Foundation, and the Finnish Foundation for Cardiovascular Research, the Emil Aaltonen Foundation, and the Paavo Nurmi Foundation.

KW - Humans

KW - Atrial Fibrillation/etiology

KW - Gastrointestinal Microbiome

KW - Heart

KW - Bacteria/genetics

KW - Aging

KW - Incidence

U2 - 10.1016/j.ebiom.2023.104583

DO - 10.1016/j.ebiom.2023.104583

M3 - SCORING: Journal article

C2 - 37119735

VL - 91

SP - 104583

JO - EBIOMEDICINE

JF - EBIOMEDICINE

SN - 2352-3964

ER -