Guidelines for Long-Term Follow-Up after Childhood Cancer: Practical Implications for the Daily Work
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Guidelines for Long-Term Follow-Up after Childhood Cancer: Practical Implications for the Daily Work. / Gebauer, Judith; Baust, Katja; Bardi, Edit; Grabow, Desiree; Stein, Alexander; van der Pal, Helena J; Calaminus, Gabriele; Langer, Thorsten.
In: ONCOL RES TREAT, Vol. 43, No. 3, 13.01.2020, p. 61-69.Research output: SCORING: Contribution to journal › SCORING: Review article › Education
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TY - JOUR
T1 - Guidelines for Long-Term Follow-Up after Childhood Cancer: Practical Implications for the Daily Work
AU - Gebauer, Judith
AU - Baust, Katja
AU - Bardi, Edit
AU - Grabow, Desiree
AU - Stein, Alexander
AU - van der Pal, Helena J
AU - Calaminus, Gabriele
AU - Langer, Thorsten
N1 - © 2020 S. Karger AG, Basel.
PY - 2020/1/13
Y1 - 2020/1/13
N2 - BACKGROUND: Many childhood cancer survivors develop treatment-associated late effects emerging years or even decades after the end of treatment. Evidence-based guidelines recommend risk-adapted screening, facilitating early diagnosis and management of these sequelae. Long-term follow-up (LTFU) in specialized late effects clinics is devised to implement screening recommendations in the care of childhood cancer survivors.OBJECTIVES: To create a practical LTFU tool for the daily practice.METHODS: Current guidelines and screening recommendations concerning LTFU in adult survivors of childhood cancer were reviewed and a comprehensive LTFU approach was developed.RESULTS: A risk stratification model assigning patients to three risk groups with different screening recommendations and frequencies is presented based on current LTFU guidelines. Furthermore, a model of LTFU in a clinical multidisciplinary team is proposed.CONCLUSIONS: Although late morbidity and mortality in childhood cancer survivors have been attenuated in the last decade by reducing treatment toxicities, a high proportion of long-term survivors already is or will still be affected by treatment-associated chronic health conditions. With the knowledge of late effects and their occurrence as a consequence of specific treatment modalities, practical LTFU recommendations are essential to achieve standardized and structured LTFU care.
AB - BACKGROUND: Many childhood cancer survivors develop treatment-associated late effects emerging years or even decades after the end of treatment. Evidence-based guidelines recommend risk-adapted screening, facilitating early diagnosis and management of these sequelae. Long-term follow-up (LTFU) in specialized late effects clinics is devised to implement screening recommendations in the care of childhood cancer survivors.OBJECTIVES: To create a practical LTFU tool for the daily practice.METHODS: Current guidelines and screening recommendations concerning LTFU in adult survivors of childhood cancer were reviewed and a comprehensive LTFU approach was developed.RESULTS: A risk stratification model assigning patients to three risk groups with different screening recommendations and frequencies is presented based on current LTFU guidelines. Furthermore, a model of LTFU in a clinical multidisciplinary team is proposed.CONCLUSIONS: Although late morbidity and mortality in childhood cancer survivors have been attenuated in the last decade by reducing treatment toxicities, a high proportion of long-term survivors already is or will still be affected by treatment-associated chronic health conditions. With the knowledge of late effects and their occurrence as a consequence of specific treatment modalities, practical LTFU recommendations are essential to achieve standardized and structured LTFU care.
U2 - 10.1159/000504200
DO - 10.1159/000504200
M3 - SCORING: Review article
C2 - 31931503
VL - 43
SP - 61
EP - 69
JO - ONCOL RES TREAT
JF - ONCOL RES TREAT
SN - 2296-5270
IS - 3
ER -