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Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies

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Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies. / Cordts, Kathrin; Grzybowski, Ricarda; Lezius, Susanne; Lüneburg, Nicole; Atzler, Dorothee; Neu, Axel; Hornig, Sönke; Böger, Rainer H; Gerloff, Christian; Magnus, Tim; Thomalla, Götz; Schwedhelm, Edzard; Grant, Peter J; Choe, Chi-Un.

In: J NEUROL SCI, Vol. 397, 15.02.2019, p. 156-161.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cordts, K, Grzybowski, R, Lezius, S, Lüneburg, N, Atzler, D, Neu, A, Hornig, S, Böger, RH, Gerloff, C, Magnus, T, Thomalla, G, Schwedhelm, E, Grant, PJ & Choe, C-U 2019, 'Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies', J NEUROL SCI, vol. 397, pp. 156-161. https://doi.org/10.1016/j.jns.2018.12.037

APA

Cordts, K., Grzybowski, R., Lezius, S., Lüneburg, N., Atzler, D., Neu, A., Hornig, S., Böger, R. H., Gerloff, C., Magnus, T., Thomalla, G., Schwedhelm, E., Grant, P. J., & Choe, C-U. (2019). Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies. J NEUROL SCI, 397, 156-161. https://doi.org/10.1016/j.jns.2018.12.037

Vancouver

Cordts K, Grzybowski R, Lezius S, Lüneburg N, Atzler D, Neu A et al. Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies. J NEUROL SCI. 2019 Feb 15;397:156-161. https://doi.org/10.1016/j.jns.2018.12.037

Bibtex

@article{caa2d193729e4281a3751f98455b3d55,
title = "Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies",
abstract = "INTRODUCTION: Guanidino compounds, including l-homoarginine (l-hArg), symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA) and l-arginine (l-Arg) are associated with mortality, fatal strokes, stroke incidence, and atherosclerosis.OBJECTIVES: We aimed to study the association of guanidino compounds (l-hArg/ADMA and l-hArg/SDMA) with stroke etiology, internal carotid artery (ICA) stenosis and CHA2DS2-VASc score in patients with cerebrovascular disease.METHODS: We analyzed l-hArg, SDMA, ADMA, l-Arg, and compound molar ratios, i.e. l-hArg/ADMA and l-hArg/SDMA, in 272 patients with cerebrovascular disease in a cross-sectional discovery cohort and two cross-sectional validation cohorts of acute stroke patients from Germany (n = 137) and UK (n = 394). The guanidino compound levels were compared with clinical, imaging, and ultrasound parameters.RESULTS: Low l-hArg/ADMA and l-hArg/SDMA molar ratios predicted territorial infarcts (OR 1.74; 95% CI 1.34-2.26 and OR 1.64; 95% CI 1.26-2.15, respectively) and were associated with stroke subtypes due to large vessel disease or cardio-embolism (OR 1.52; 95% CI 1.12-2.06 and OR 2.01; 95% CI 1.35-3.00, respectively) in meta-analysis of the discovery and validation cohort data. In line with these results, a low l-hArg/ADMA and l-hArg/SDMA molar ratio was found in patients with ICA stenosis (OR 0.73; 95% CI 0.55-0.97 and OR 0.69; 95% CI 0.50-0.94, respectively) in the discovery and validation cohort. Furthermore, guanidino compound ratios (i.e. l-hArg/ADMA and l-hArg/SDMA) were strongly correlated with CHA2DS2-VASC score (p < .001) in all three cohorts.DISCUSSION: The results from these three cross-sectional studies reveal that guanidino compound ratios (i.e. l-hArg/ADMA and l-hArg/SDMA) can discriminate stroke etiologies, predict ICA stenosis and estimate risk prediction in patients with cerebrovascular disease.",
author = "Kathrin Cordts and Ricarda Grzybowski and Susanne Lezius and Nicole L{\"u}neburg and Dorothee Atzler and Axel Neu and S{\"o}nke Hornig and B{\"o}ger, {Rainer H} and Christian Gerloff and Tim Magnus and G{\"o}tz Thomalla and Edzard Schwedhelm and Grant, {Peter J} and Chi-Un Choe",
note = "Copyright {\textcopyright} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = feb,
day = "15",
doi = "10.1016/j.jns.2018.12.037",
language = "English",
volume = "397",
pages = "156--161",
journal = "J NEUROL SCI",
issn = "0022-510X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Guanidino compound ratios are associated with stroke etiology, internal carotid artery stenosis and CHA(2)DS(2)-VASc score in three cross-sectional studies

AU - Cordts, Kathrin

AU - Grzybowski, Ricarda

AU - Lezius, Susanne

AU - Lüneburg, Nicole

AU - Atzler, Dorothee

AU - Neu, Axel

AU - Hornig, Sönke

AU - Böger, Rainer H

AU - Gerloff, Christian

AU - Magnus, Tim

AU - Thomalla, Götz

AU - Schwedhelm, Edzard

AU - Grant, Peter J

AU - Choe, Chi-Un

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/2/15

Y1 - 2019/2/15

N2 - INTRODUCTION: Guanidino compounds, including l-homoarginine (l-hArg), symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA) and l-arginine (l-Arg) are associated with mortality, fatal strokes, stroke incidence, and atherosclerosis.OBJECTIVES: We aimed to study the association of guanidino compounds (l-hArg/ADMA and l-hArg/SDMA) with stroke etiology, internal carotid artery (ICA) stenosis and CHA2DS2-VASc score in patients with cerebrovascular disease.METHODS: We analyzed l-hArg, SDMA, ADMA, l-Arg, and compound molar ratios, i.e. l-hArg/ADMA and l-hArg/SDMA, in 272 patients with cerebrovascular disease in a cross-sectional discovery cohort and two cross-sectional validation cohorts of acute stroke patients from Germany (n = 137) and UK (n = 394). The guanidino compound levels were compared with clinical, imaging, and ultrasound parameters.RESULTS: Low l-hArg/ADMA and l-hArg/SDMA molar ratios predicted territorial infarcts (OR 1.74; 95% CI 1.34-2.26 and OR 1.64; 95% CI 1.26-2.15, respectively) and were associated with stroke subtypes due to large vessel disease or cardio-embolism (OR 1.52; 95% CI 1.12-2.06 and OR 2.01; 95% CI 1.35-3.00, respectively) in meta-analysis of the discovery and validation cohort data. In line with these results, a low l-hArg/ADMA and l-hArg/SDMA molar ratio was found in patients with ICA stenosis (OR 0.73; 95% CI 0.55-0.97 and OR 0.69; 95% CI 0.50-0.94, respectively) in the discovery and validation cohort. Furthermore, guanidino compound ratios (i.e. l-hArg/ADMA and l-hArg/SDMA) were strongly correlated with CHA2DS2-VASC score (p < .001) in all three cohorts.DISCUSSION: The results from these three cross-sectional studies reveal that guanidino compound ratios (i.e. l-hArg/ADMA and l-hArg/SDMA) can discriminate stroke etiologies, predict ICA stenosis and estimate risk prediction in patients with cerebrovascular disease.

AB - INTRODUCTION: Guanidino compounds, including l-homoarginine (l-hArg), symmetric dimethylarginine (SDMA), asymmetric dimethylarginine (ADMA) and l-arginine (l-Arg) are associated with mortality, fatal strokes, stroke incidence, and atherosclerosis.OBJECTIVES: We aimed to study the association of guanidino compounds (l-hArg/ADMA and l-hArg/SDMA) with stroke etiology, internal carotid artery (ICA) stenosis and CHA2DS2-VASc score in patients with cerebrovascular disease.METHODS: We analyzed l-hArg, SDMA, ADMA, l-Arg, and compound molar ratios, i.e. l-hArg/ADMA and l-hArg/SDMA, in 272 patients with cerebrovascular disease in a cross-sectional discovery cohort and two cross-sectional validation cohorts of acute stroke patients from Germany (n = 137) and UK (n = 394). The guanidino compound levels were compared with clinical, imaging, and ultrasound parameters.RESULTS: Low l-hArg/ADMA and l-hArg/SDMA molar ratios predicted territorial infarcts (OR 1.74; 95% CI 1.34-2.26 and OR 1.64; 95% CI 1.26-2.15, respectively) and were associated with stroke subtypes due to large vessel disease or cardio-embolism (OR 1.52; 95% CI 1.12-2.06 and OR 2.01; 95% CI 1.35-3.00, respectively) in meta-analysis of the discovery and validation cohort data. In line with these results, a low l-hArg/ADMA and l-hArg/SDMA molar ratio was found in patients with ICA stenosis (OR 0.73; 95% CI 0.55-0.97 and OR 0.69; 95% CI 0.50-0.94, respectively) in the discovery and validation cohort. Furthermore, guanidino compound ratios (i.e. l-hArg/ADMA and l-hArg/SDMA) were strongly correlated with CHA2DS2-VASC score (p < .001) in all three cohorts.DISCUSSION: The results from these three cross-sectional studies reveal that guanidino compound ratios (i.e. l-hArg/ADMA and l-hArg/SDMA) can discriminate stroke etiologies, predict ICA stenosis and estimate risk prediction in patients with cerebrovascular disease.

U2 - 10.1016/j.jns.2018.12.037

DO - 10.1016/j.jns.2018.12.037

M3 - SCORING: Journal article

C2 - 30640152

VL - 397

SP - 156

EP - 161

JO - J NEUROL SCI

JF - J NEUROL SCI

SN - 0022-510X

ER -