Research ExplorerPublicationsGrowth differentiation factor-15 in the early diagnosis and ...

Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain

Standard

Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain. / Schaub, Nora; Reichlin, Tobias; Twerenbold, Raphael; Reiter, Miriam; Steuer, Stephan; Bassetti, Stefano; Stelzig, Claudia; Wolf, Claudia; Winkler, Katrin; Haaf, Philip; Meissner, Julia; Drexler, Beatrice; Mueller, Christian.

In: CLIN CHEM, Vol. 58, No. 2, 02.2012, p. 441-9.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schaub, N, Reichlin, T, Twerenbold, R, Reiter, M, Steuer, S, Bassetti, S, Stelzig, C, Wolf, C, Winkler, K, Haaf, P, Meissner, J, Drexler, B & Mueller, C 2012, 'Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain', CLIN CHEM, vol. 58, no. 2, pp. 441-9. https://doi.org/10.1373/clinchem.2011.173310

APA

Schaub, N., Reichlin, T., Twerenbold, R., Reiter, M., Steuer, S., Bassetti, S., Stelzig, C., Wolf, C., Winkler, K., Haaf, P., Meissner, J., Drexler, B., & Mueller, C. (2012). Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain. CLIN CHEM, 58(2), 441-9. https://doi.org/10.1373/clinchem.2011.173310

Vancouver

Schaub N, Reichlin T, Twerenbold R, Reiter M, Steuer S, Bassetti S et al. Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain. CLIN CHEM. 2012 Feb;58(2):441-9. https://doi.org/10.1373/clinchem.2011.173310

Bibtex

@article{86a3a1ca24ed474485d2f54818da7dd4,
title = "Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain",
abstract = "BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-responsive marker that might aid in the early diagnosis and risk stratification of patients with suspected acute myocardial infarction (AMI).METHODS: In a prospective, international multicenter study, GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and B-type natriuretic peptide (BNP) were measured in 646 unselected patients presenting to the emergency department with acute chest pain. The final diagnosis was adjudicated by 2 independent cardiologists. The primary prognostic end point was all-cause mortality during a median follow-up of 26 months.RESULTS: AMI was the adjudicated final diagnosis in 115 patients (18%). GDF-15 concentrations at presentation were significantly higher in AMI patients compared to patients with other diagnoses. The diagnostic accuracy of GDF-15 at presentation for the diagnosis of AMI as quantified by the area under the ROC curve (AUC) was lower (AUC 0.69, 95% CI 0.64-0.74) compared to hs-cTnT (AUC 0.96, 95% CI 0.94-0.98, P < 0.001) and BNP (AUC 0.74, 95% CI 0.69-0.80, P = 0.02). A total of 55 deaths occurred during follow-up. GDF-15 predicted all-cause mortality independently of and more accurately than hs-cTnT [AUC 0.85 (95% CI 0.81-0.90) vs 0.77 (95% CI 0.72-0.83), P = 0.002] and BNP (AUC 0.75, 95% CI 0.68-0.82, P = 0.007). Net reclassification improvement was 0.15 (P = 0.01), and the absolute integrated discrimination improvement was 0.07, yielding a relative integrated discrimination improvement of 0.36 (P = 0.07).CONCLUSIONS: GDF-15 predicts all-cause mortality in unselected patients with acute chest pain independently of and more accurately than hs-cTnT and BNP. However, GDF-15 does not seem to help in the early diagnosis of AMI.",
keywords = "Acute Disease, Aged, Aged, 80 and over, Angina, Unstable/diagnosis, Biomarkers/blood, Chest Pain/diagnosis, Early Diagnosis, Female, Growth Differentiation Factor 15/blood, Humans, Male, Middle Aged, Mortality, Myocardial Infarction/diagnosis, Natriuretic Peptide, Brain/blood, Prognosis, Prospective Studies, Risk Assessment, Troponin T/blood",
author = "Nora Schaub and Tobias Reichlin and Raphael Twerenbold and Miriam Reiter and Stephan Steuer and Stefano Bassetti and Claudia Stelzig and Claudia Wolf and Katrin Winkler and Philip Haaf and Julia Meissner and Beatrice Drexler and Christian Mueller",
year = "2012",
month = feb,
doi = "10.1373/clinchem.2011.173310",
language = "English",
volume = "58",
pages = "441--9",
journal = "CLIN CHEM",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Growth differentiation factor-15 in the early diagnosis and risk stratification of patients with acute chest pain

AU - Schaub, Nora

AU - Reichlin, Tobias

AU - Twerenbold, Raphael

AU - Reiter, Miriam

AU - Steuer, Stephan

AU - Bassetti, Stefano

AU - Stelzig, Claudia

AU - Wolf, Claudia

AU - Winkler, Katrin

AU - Haaf, Philip

AU - Meissner, Julia

AU - Drexler, Beatrice

AU - Mueller, Christian

PY - 2012/2

Y1 - 2012/2

N2 - BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-responsive marker that might aid in the early diagnosis and risk stratification of patients with suspected acute myocardial infarction (AMI).METHODS: In a prospective, international multicenter study, GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and B-type natriuretic peptide (BNP) were measured in 646 unselected patients presenting to the emergency department with acute chest pain. The final diagnosis was adjudicated by 2 independent cardiologists. The primary prognostic end point was all-cause mortality during a median follow-up of 26 months.RESULTS: AMI was the adjudicated final diagnosis in 115 patients (18%). GDF-15 concentrations at presentation were significantly higher in AMI patients compared to patients with other diagnoses. The diagnostic accuracy of GDF-15 at presentation for the diagnosis of AMI as quantified by the area under the ROC curve (AUC) was lower (AUC 0.69, 95% CI 0.64-0.74) compared to hs-cTnT (AUC 0.96, 95% CI 0.94-0.98, P < 0.001) and BNP (AUC 0.74, 95% CI 0.69-0.80, P = 0.02). A total of 55 deaths occurred during follow-up. GDF-15 predicted all-cause mortality independently of and more accurately than hs-cTnT [AUC 0.85 (95% CI 0.81-0.90) vs 0.77 (95% CI 0.72-0.83), P = 0.002] and BNP (AUC 0.75, 95% CI 0.68-0.82, P = 0.007). Net reclassification improvement was 0.15 (P = 0.01), and the absolute integrated discrimination improvement was 0.07, yielding a relative integrated discrimination improvement of 0.36 (P = 0.07).CONCLUSIONS: GDF-15 predicts all-cause mortality in unselected patients with acute chest pain independently of and more accurately than hs-cTnT and BNP. However, GDF-15 does not seem to help in the early diagnosis of AMI.

AB - BACKGROUND: Growth differentiation factor-15 (GDF-15) is a stress-responsive marker that might aid in the early diagnosis and risk stratification of patients with suspected acute myocardial infarction (AMI).METHODS: In a prospective, international multicenter study, GDF-15, high-sensitivity cardiac troponin T (hs-cTnT), and B-type natriuretic peptide (BNP) were measured in 646 unselected patients presenting to the emergency department with acute chest pain. The final diagnosis was adjudicated by 2 independent cardiologists. The primary prognostic end point was all-cause mortality during a median follow-up of 26 months.RESULTS: AMI was the adjudicated final diagnosis in 115 patients (18%). GDF-15 concentrations at presentation were significantly higher in AMI patients compared to patients with other diagnoses. The diagnostic accuracy of GDF-15 at presentation for the diagnosis of AMI as quantified by the area under the ROC curve (AUC) was lower (AUC 0.69, 95% CI 0.64-0.74) compared to hs-cTnT (AUC 0.96, 95% CI 0.94-0.98, P < 0.001) and BNP (AUC 0.74, 95% CI 0.69-0.80, P = 0.02). A total of 55 deaths occurred during follow-up. GDF-15 predicted all-cause mortality independently of and more accurately than hs-cTnT [AUC 0.85 (95% CI 0.81-0.90) vs 0.77 (95% CI 0.72-0.83), P = 0.002] and BNP (AUC 0.75, 95% CI 0.68-0.82, P = 0.007). Net reclassification improvement was 0.15 (P = 0.01), and the absolute integrated discrimination improvement was 0.07, yielding a relative integrated discrimination improvement of 0.36 (P = 0.07).CONCLUSIONS: GDF-15 predicts all-cause mortality in unselected patients with acute chest pain independently of and more accurately than hs-cTnT and BNP. However, GDF-15 does not seem to help in the early diagnosis of AMI.

KW - Acute Disease

KW - Aged

KW - Aged, 80 and over

KW - Angina, Unstable/diagnosis

KW - Biomarkers/blood

KW - Chest Pain/diagnosis

KW - Early Diagnosis

KW - Female

KW - Growth Differentiation Factor 15/blood

KW - Humans

KW - Male

KW - Middle Aged

KW - Mortality

KW - Myocardial Infarction/diagnosis

KW - Natriuretic Peptide, Brain/blood

KW - Prognosis

KW - Prospective Studies

KW - Risk Assessment

KW - Troponin T/blood

U2 - 10.1373/clinchem.2011.173310

DO - 10.1373/clinchem.2011.173310

M3 - SCORING: Journal article

C2 - 22205695

VL - 58

SP - 441

EP - 449

JO - CLIN CHEM

JF - CLIN CHEM

SN - 0009-9147

IS - 2

ER -