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Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

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Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice. / Moschovaki-Filippidou, Foteini; Steiger, Stefanie; Lorenz, Georg; Schmaderer, Christoph; Ribeiro, Andrea; von Rauchhaupt, Ekaterina; Cohen, Clemens D; Anders, Hans-Joachim; Lindenmeyer, Maja; Lech, Maciej.

In: INT J MOL SCI, Vol. 21, No. 19, 23.09.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Moschovaki-Filippidou, F, Steiger, S, Lorenz, G, Schmaderer, C, Ribeiro, A, von Rauchhaupt, E, Cohen, CD, Anders, H-J, Lindenmeyer, M & Lech, M 2020, 'Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice', INT J MOL SCI, vol. 21, no. 19. https://doi.org/10.3390/ijms21196978

APA

Moschovaki-Filippidou, F., Steiger, S., Lorenz, G., Schmaderer, C., Ribeiro, A., von Rauchhaupt, E., Cohen, C. D., Anders, H-J., Lindenmeyer, M., & Lech, M. (2020). Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice. INT J MOL SCI, 21(19). https://doi.org/10.3390/ijms21196978

Vancouver

Moschovaki-Filippidou F, Steiger S, Lorenz G, Schmaderer C, Ribeiro A, von Rauchhaupt E et al. Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice. INT J MOL SCI. 2020 Sep 23;21(19). https://doi.org/10.3390/ijms21196978

Bibtex

@article{9298a200009841389c6b7312c97217f8,
title = "Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice",
abstract = "Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.",
author = "Foteini Moschovaki-Filippidou and Stefanie Steiger and Georg Lorenz and Christoph Schmaderer and Andrea Ribeiro and {von Rauchhaupt}, Ekaterina and Cohen, {Clemens D} and Hans-Joachim Anders and Maja Lindenmeyer and Maciej Lech",
year = "2020",
month = sep,
day = "23",
doi = "10.3390/ijms21196978",
language = "English",
volume = "21",
journal = "INT J MOL SCI",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "19",

}

RIS

TY - JOUR

T1 - Growth Differentiation Factor 15 Ameliorates Anti-Glomerular Basement Membrane Glomerulonephritis in Mice

AU - Moschovaki-Filippidou, Foteini

AU - Steiger, Stefanie

AU - Lorenz, Georg

AU - Schmaderer, Christoph

AU - Ribeiro, Andrea

AU - von Rauchhaupt, Ekaterina

AU - Cohen, Clemens D

AU - Anders, Hans-Joachim

AU - Lindenmeyer, Maja

AU - Lech, Maciej

PY - 2020/9/23

Y1 - 2020/9/23

N2 - Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.

AB - Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) cytokine family and an inflammation-associated protein. Here, we investigated the role of GDF15 in murine anti-glomerular basement membrane (GBM) glomerulonephritis. Glomerulonephritis induction in mice induced systemic expression of GDF15. Moreover, we demonstrate the protective effects for GDF15, as GDF15-deficient mice exhibited increased proteinuria with an aggravated crescent formation and mesangial expansion in anti-GBM nephritis. Herein, GDF15 was required for the regulation of T-cell chemotactic chemokines in the kidney. In addition, we found the upregulation of the CXCR3 receptor in activated T-cells in GDF15-deficient mice. These data indicate that CXCL10/CXCR3-dependent-signaling promotes the infiltration of T cells into the organ during acute inflammation controlled by GDF15. Together, these results reveal a novel mechanism limiting the migration of lymphocytes to the site of inflammation during glomerulonephritis.

U2 - 10.3390/ijms21196978

DO - 10.3390/ijms21196978

M3 - SCORING: Journal article

C2 - 32977372

VL - 21

JO - INT J MOL SCI

JF - INT J MOL SCI

SN - 1661-6596

IS - 19

ER -