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Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines

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Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines. / Vinnemeier, C D; Brust, Patrick; Owusu-Dabo, E; Sarpong, N; Sarfo, E Y; Bio, Y; Rolling, T; Dekker, D; Adu-Sarkodie, Y; Eberhardt, K A; May, J; Cramer, J P.

In: TROP MED INT HEALTH, Vol. 20, No. 11, 11.2015, p. 1516-24.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Vinnemeier, CD, Brust, P, Owusu-Dabo, E, Sarpong, N, Sarfo, EY, Bio, Y, Rolling, T, Dekker, D, Adu-Sarkodie, Y, Eberhardt, KA, May, J & Cramer, JP 2015, 'Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines', TROP MED INT HEALTH, vol. 20, no. 11, pp. 1516-24. https://doi.org/10.1111/tmi.12589

APA

Vinnemeier, C. D., Brust, P., Owusu-Dabo, E., Sarpong, N., Sarfo, E. Y., Bio, Y., Rolling, T., Dekker, D., Adu-Sarkodie, Y., Eberhardt, K. A., May, J., & Cramer, J. P. (2015). Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines. TROP MED INT HEALTH, 20(11), 1516-24. https://doi.org/10.1111/tmi.12589

Vancouver

Vinnemeier CD, Brust P, Owusu-Dabo E, Sarpong N, Sarfo EY, Bio Y et al. Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines. TROP MED INT HEALTH. 2015 Nov;20(11):1516-24. https://doi.org/10.1111/tmi.12589

Bibtex

@article{1e6419b7fc864425932511953c46447a,
title = "Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines",
abstract = "OBJECTIVE: To assess the prevalence and serotype distribution of Group B Streptococcus (GBS) in Ghana since colonization of pregnant women can lead to subsequent infection of the newborn and potentially fatal invasive disease and this knowledge is a prerequisite for future evaluation of vaccine trials.METHODS: Double-centre study conducted in one rural and one urban hospital in central Ghana, West Africa. Women in late pregnancy (≥35 weeks of gestation) attending the antenatal care clinic (ANC) provided recto-vaginal swabs for GBS-testing. GBS isolates were analysed for serotype and antibiotic susceptibility. GBS-positive women were treated with intrapartum antibiotic prophylaxis (IAP) according to current guidelines of the Center for Disease Control and Prevention (CDC).RESULTS: 519 women were recruited at both study sites, recto-vaginal swabs were taken from 509. The overall prevalence of GBS was 19.1% (18.1% in rural Pramso and 23.1% in urban Kumasi). Capsular polysaccharide serotype (CPS) Ia was the most frequent (28.1%), followed by serotype V (27.1%) and III (21.9%). No resistance to penicillin was detected; but there was resistance to second-line antibiotics clindamycin (3.1%) and erythromycin (1%).DISCUSSION: GBS serotype distribution in Ghana is similar to that worldwide, but variations in prevalence of certain serotypes between the urban and rural study were high. Antibiotic resistance of GBS strains was surprisingly low in this study. This article is protected by copyright. All rights reserved.",
author = "Vinnemeier, {C D} and Patrick Brust and E Owusu-Dabo and N Sarpong and Sarfo, {E Y} and Y Bio and T Rolling and D Dekker and Y Adu-Sarkodie and Eberhardt, {K A} and J May and Cramer, {J P}",
note = "This article is protected by copyright. All rights reserved.",
year = "2015",
month = nov,
doi = "10.1111/tmi.12589",
language = "English",
volume = "20",
pages = "1516--24",
journal = "TROP MED INT HEALTH",
issn = "1360-2276",
publisher = "Wiley-Blackwell",
number = "11",

}

RIS

TY - JOUR

T1 - Group B Streptococci Serotype Distribution in Pregnant Women in Ghana Assessment of Potential Coverage Through Future Vaccines

AU - Vinnemeier, C D

AU - Brust, Patrick

AU - Owusu-Dabo, E

AU - Sarpong, N

AU - Sarfo, E Y

AU - Bio, Y

AU - Rolling, T

AU - Dekker, D

AU - Adu-Sarkodie, Y

AU - Eberhardt, K A

AU - May, J

AU - Cramer, J P

N1 - This article is protected by copyright. All rights reserved.

PY - 2015/11

Y1 - 2015/11

N2 - OBJECTIVE: To assess the prevalence and serotype distribution of Group B Streptococcus (GBS) in Ghana since colonization of pregnant women can lead to subsequent infection of the newborn and potentially fatal invasive disease and this knowledge is a prerequisite for future evaluation of vaccine trials.METHODS: Double-centre study conducted in one rural and one urban hospital in central Ghana, West Africa. Women in late pregnancy (≥35 weeks of gestation) attending the antenatal care clinic (ANC) provided recto-vaginal swabs for GBS-testing. GBS isolates were analysed for serotype and antibiotic susceptibility. GBS-positive women were treated with intrapartum antibiotic prophylaxis (IAP) according to current guidelines of the Center for Disease Control and Prevention (CDC).RESULTS: 519 women were recruited at both study sites, recto-vaginal swabs were taken from 509. The overall prevalence of GBS was 19.1% (18.1% in rural Pramso and 23.1% in urban Kumasi). Capsular polysaccharide serotype (CPS) Ia was the most frequent (28.1%), followed by serotype V (27.1%) and III (21.9%). No resistance to penicillin was detected; but there was resistance to second-line antibiotics clindamycin (3.1%) and erythromycin (1%).DISCUSSION: GBS serotype distribution in Ghana is similar to that worldwide, but variations in prevalence of certain serotypes between the urban and rural study were high. Antibiotic resistance of GBS strains was surprisingly low in this study. This article is protected by copyright. All rights reserved.

AB - OBJECTIVE: To assess the prevalence and serotype distribution of Group B Streptococcus (GBS) in Ghana since colonization of pregnant women can lead to subsequent infection of the newborn and potentially fatal invasive disease and this knowledge is a prerequisite for future evaluation of vaccine trials.METHODS: Double-centre study conducted in one rural and one urban hospital in central Ghana, West Africa. Women in late pregnancy (≥35 weeks of gestation) attending the antenatal care clinic (ANC) provided recto-vaginal swabs for GBS-testing. GBS isolates were analysed for serotype and antibiotic susceptibility. GBS-positive women were treated with intrapartum antibiotic prophylaxis (IAP) according to current guidelines of the Center for Disease Control and Prevention (CDC).RESULTS: 519 women were recruited at both study sites, recto-vaginal swabs were taken from 509. The overall prevalence of GBS was 19.1% (18.1% in rural Pramso and 23.1% in urban Kumasi). Capsular polysaccharide serotype (CPS) Ia was the most frequent (28.1%), followed by serotype V (27.1%) and III (21.9%). No resistance to penicillin was detected; but there was resistance to second-line antibiotics clindamycin (3.1%) and erythromycin (1%).DISCUSSION: GBS serotype distribution in Ghana is similar to that worldwide, but variations in prevalence of certain serotypes between the urban and rural study were high. Antibiotic resistance of GBS strains was surprisingly low in this study. This article is protected by copyright. All rights reserved.

U2 - 10.1111/tmi.12589

DO - 10.1111/tmi.12589

M3 - SCORING: Journal article

C2 - 26285044

VL - 20

SP - 1516

EP - 1524

JO - TROP MED INT HEALTH

JF - TROP MED INT HEALTH

SN - 1360-2276

IS - 11

ER -