Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period
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Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period. / Schwarz, J; Scheckenbach, V; Kugel, H; Spring, B; Pagel, J; Härtel, C; Pauluschke-Fröhlich, J; Peter, A; Poets, C F; Gille, C; Köstlin, N.
In: CLIN EXP IMMUNOL, Vol. 191, No. 3, 03.2018, p. 328-337.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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T1 - Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period
AU - Schwarz, J
AU - Scheckenbach, V
AU - Kugel, H
AU - Spring, B
AU - Pagel, J
AU - Härtel, C
AU - Pauluschke-Fröhlich, J
AU - Peter, A
AU - Poets, C F
AU - Gille, C
AU - Köstlin, N
N1 - © 2017 British Society for Immunology.
PY - 2018/3
Y1 - 2018/3
N2 - Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal-fetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR-MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR-MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR-MDSC accumulate further and correlate with inflammatory markers C-reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR-MDSC for immune-regulation in preterm infants and render them as a potential target for cell-based therapy of infections in these patients.
AB - Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal-fetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR-MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR-MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR-MDSC accumulate further and correlate with inflammatory markers C-reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR-MDSC for immune-regulation in preterm infants and render them as a potential target for cell-based therapy of infections in these patients.
KW - Adult
KW - C-Reactive Protein/metabolism
KW - Female
KW - Fetal Blood/physiology
KW - Flow Cytometry
KW - Granulocytes/physiology
KW - Humans
KW - Immune Tolerance
KW - Immunotherapy, Adoptive/methods
KW - Infant
KW - Infant, Newborn
KW - Infant, Newborn, Diseases/immunology
KW - Infant, Premature
KW - Infections/immunology
KW - Male
KW - Myeloid-Derived Suppressor Cells/physiology
KW - Obstetric Labor, Premature/immunology
KW - Pregnancy
U2 - 10.1111/cei.13059
DO - 10.1111/cei.13059
M3 - SCORING: Journal article
C2 - 28963753
VL - 191
SP - 328
EP - 337
JO - CLIN EXP IMMUNOL
JF - CLIN EXP IMMUNOL
SN - 0009-9104
IS - 3
ER -