Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period

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Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period. / Schwarz, J; Scheckenbach, V; Kugel, H; Spring, B; Pagel, J; Härtel, C; Pauluschke-Fröhlich, J; Peter, A; Poets, C F; Gille, C; Köstlin, N.

In: CLIN EXP IMMUNOL, Vol. 191, No. 3, 03.2018, p. 328-337.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearchpeer-review

Harvard

Schwarz, J, Scheckenbach, V, Kugel, H, Spring, B, Pagel, J, Härtel, C, Pauluschke-Fröhlich, J, Peter, A, Poets, CF, Gille, C & Köstlin, N 2018, 'Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period', CLIN EXP IMMUNOL, vol. 191, no. 3, pp. 328-337. https://doi.org/10.1111/cei.13059

APA

Schwarz, J., Scheckenbach, V., Kugel, H., Spring, B., Pagel, J., Härtel, C., Pauluschke-Fröhlich, J., Peter, A., Poets, C. F., Gille, C., & Köstlin, N. (2018). Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period. CLIN EXP IMMUNOL, 191(3), 328-337. https://doi.org/10.1111/cei.13059

Vancouver

Bibtex

@article{3e091cdcaa0449a997b154f1e5d0795c,
title = "Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period",
abstract = "Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal-fetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR-MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR-MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR-MDSC accumulate further and correlate with inflammatory markers C-reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR-MDSC for immune-regulation in preterm infants and render them as a potential target for cell-based therapy of infections in these patients.",
keywords = "Adult, C-Reactive Protein/metabolism, Female, Fetal Blood/physiology, Flow Cytometry, Granulocytes/physiology, Humans, Immune Tolerance, Immunotherapy, Adoptive/methods, Infant, Infant, Newborn, Infant, Newborn, Diseases/immunology, Infant, Premature, Infections/immunology, Male, Myeloid-Derived Suppressor Cells/physiology, Obstetric Labor, Premature/immunology, Pregnancy",
author = "J Schwarz and V Scheckenbach and H Kugel and B Spring and J Pagel and C H{\"a}rtel and J Pauluschke-Fr{\"o}hlich and A Peter and Poets, {C F} and C Gille and N K{\"o}stlin",
note = "{\textcopyright} 2017 British Society for Immunology.",
year = "2018",
month = mar,
doi = "10.1111/cei.13059",
language = "English",
volume = "191",
pages = "328--337",
journal = "CLIN EXP IMMUNOL",
issn = "0009-9104",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Granulocytic myeloid-derived suppressor cells (GR-MDSC) accumulate in cord blood of preterm infants and remain elevated during the neonatal period

AU - Schwarz, J

AU - Scheckenbach, V

AU - Kugel, H

AU - Spring, B

AU - Pagel, J

AU - Härtel, C

AU - Pauluschke-Fröhlich, J

AU - Peter, A

AU - Poets, C F

AU - Gille, C

AU - Köstlin, N

N1 - © 2017 British Society for Immunology.

PY - 2018/3

Y1 - 2018/3

N2 - Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal-fetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR-MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR-MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR-MDSC accumulate further and correlate with inflammatory markers C-reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR-MDSC for immune-regulation in preterm infants and render them as a potential target for cell-based therapy of infections in these patients.

AB - Preterm delivery is the leading cause of perinatal morbidity and mortality. Among the most important complications in preterm infants are peri- or postnatal infections. Myeloid-derived suppressor cells (MDSC) are myeloid cells with suppressive activity on other immune cells. Emerging evidence suggests that granulocytic MDSC (GR-MDSC) play a pivotal role in mediating maternal-fetal tolerance. The role of MDSC for postnatal immune-regulation in neonates is incompletely understood. Until the present time, nothing was known about expression of MDSC in preterm infants. In the present pilot study, we quantified GR-MDSC counts in cord blood and peripheral blood of preterm infants born between 23 + 0 and 36 + 6 weeks of gestation (WOG) during the first 3 months of life and analysed the effect of perinatal infections. We show that GR-MDSC are increased in cord blood independent of gestational age and remain elevated in peripheral blood of preterm infants during the neonatal period. After day 28 they drop to nearly adult levels. In case of perinatal or postnatal infection, GR-MDSC accumulate further and correlate with inflammatory markers C-reactive protein (CRP) and white blood cell counts (WBC). Our results point towards a role of GR-MDSC for immune-regulation in preterm infants and render them as a potential target for cell-based therapy of infections in these patients.

KW - Adult

KW - C-Reactive Protein/metabolism

KW - Female

KW - Fetal Blood/physiology

KW - Flow Cytometry

KW - Granulocytes/physiology

KW - Humans

KW - Immune Tolerance

KW - Immunotherapy, Adoptive/methods

KW - Infant

KW - Infant, Newborn

KW - Infant, Newborn, Diseases/immunology

KW - Infant, Premature

KW - Infections/immunology

KW - Male

KW - Myeloid-Derived Suppressor Cells/physiology

KW - Obstetric Labor, Premature/immunology

KW - Pregnancy

U2 - 10.1111/cei.13059

DO - 10.1111/cei.13059

M3 - SCORING: Journal article

C2 - 28963753

VL - 191

SP - 328

EP - 337

JO - CLIN EXP IMMUNOL

JF - CLIN EXP IMMUNOL

SN - 0009-9104

IS - 3

ER -