Granulocyte-colony stimulating factor response is superior to neutropenia duration in predicting the risk of infection after high-dose chemotherapy for myeloma and lymphoma
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Granulocyte-colony stimulating factor response is superior to neutropenia duration in predicting the risk of infection after high-dose chemotherapy for myeloma and lymphoma. / Straka, Christian; Salwender, Hans; Schnabel, Brigitte; Sandherr, Michael; Wandt, Hannes; Hübel, Kai; Scheid, Christof; Metzner, Bernd; Hentrich, Marcus; Franke, Daniel; Weidenegger, Gloria; Freund, Mathias; Sezer, Orhan; Einsele, Hermann; Hinke, Axel; Emmerich, Bertold.
In: LEUKEMIA LYMPHOMA, Vol. 56, No. 2, 02.2015, p. 368-76.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Granulocyte-colony stimulating factor response is superior to neutropenia duration in predicting the risk of infection after high-dose chemotherapy for myeloma and lymphoma
AU - Straka, Christian
AU - Salwender, Hans
AU - Schnabel, Brigitte
AU - Sandherr, Michael
AU - Wandt, Hannes
AU - Hübel, Kai
AU - Scheid, Christof
AU - Metzner, Bernd
AU - Hentrich, Marcus
AU - Franke, Daniel
AU - Weidenegger, Gloria
AU - Freund, Mathias
AU - Sezer, Orhan
AU - Einsele, Hermann
AU - Hinke, Axel
AU - Emmerich, Bertold
PY - 2015/2
Y1 - 2015/2
N2 - The patient granulocyte-colony stimulating factor (G-CSF) response is represented by the leukocyte peak in the blood induced by a single dose of G-CSF after chemotherapy, and is correlated with subsequent neutropenic infection risk. General patterns for a meaningful risk group stratification, have not yet been determined. Two independent data sets including a total of 306 cases with myeloma or lymphoma and autologous blood stem cell transplant were available. An infection susceptibility curve plotted according to ranked G-CSF responses from a multicenter study reproduced and validated a curve from the previous single center. Two trend changes were seen within these curves at around 11,000 and 22,000 leukocytes/μL, which separated three groups with a high, medium and low risk of infection. While G-CSF response is related to the consecutive duration of neutropenia, it retains additional independent predictive information for infection risk (p<0.0001) and, more important, is a tool available before the onset of the critical period.
AB - The patient granulocyte-colony stimulating factor (G-CSF) response is represented by the leukocyte peak in the blood induced by a single dose of G-CSF after chemotherapy, and is correlated with subsequent neutropenic infection risk. General patterns for a meaningful risk group stratification, have not yet been determined. Two independent data sets including a total of 306 cases with myeloma or lymphoma and autologous blood stem cell transplant were available. An infection susceptibility curve plotted according to ranked G-CSF responses from a multicenter study reproduced and validated a curve from the previous single center. Two trend changes were seen within these curves at around 11,000 and 22,000 leukocytes/μL, which separated three groups with a high, medium and low risk of infection. While G-CSF response is related to the consecutive duration of neutropenia, it retains additional independent predictive information for infection risk (p<0.0001) and, more important, is a tool available before the onset of the critical period.
U2 - 10.3109/10428194.2014.919631
DO - 10.3109/10428194.2014.919631
M3 - SCORING: Journal article
C2 - 24794810
VL - 56
SP - 368
EP - 376
JO - LEUKEMIA LYMPHOMA
JF - LEUKEMIA LYMPHOMA
SN - 1042-8194
IS - 2
ER -
