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Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery

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Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery. / Gatti, Giuseppe; Perrotti, Andrea; Reichart, Daniel; Maschietto, Luca; Onorati, Francesco; Chocron, Sidney; Dalén, Magnus; Svenarud, Peter; Faggian, Giuseppe; Santarpino, Giuseppe; Fischlein, Theodor; Pappalardo, Aniello; Maselli, Daniele; Dominici, Carmelo; Nardella, Saverio; Rubino, Antonino S; De Feo, Marisa; Santini, Francesco; Nicolini, Francesco; Gherli, Riccardo; Mariscalco, Giovanni; Tauriainen, Tuomas; Kinnunen, Eeva-Maija; Ruggieri, Vito G; Saccocci, Matteo; Biancari, Fausto.

In: CIRC J, Vol. 81, No. 1, 22.12.2016, p. 36-43.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Gatti, G, Perrotti, A, Reichart, D, Maschietto, L, Onorati, F, Chocron, S, Dalén, M, Svenarud, P, Faggian, G, Santarpino, G, Fischlein, T, Pappalardo, A, Maselli, D, Dominici, C, Nardella, S, Rubino, AS, De Feo, M, Santini, F, Nicolini, F, Gherli, R, Mariscalco, G, Tauriainen, T, Kinnunen, E-M, Ruggieri, VG, Saccocci, M & Biancari, F 2016, 'Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery', CIRC J, vol. 81, no. 1, pp. 36-43. https://doi.org/10.1253/circj.CJ-16-0778

APA

Gatti, G., Perrotti, A., Reichart, D., Maschietto, L., Onorati, F., Chocron, S., Dalén, M., Svenarud, P., Faggian, G., Santarpino, G., Fischlein, T., Pappalardo, A., Maselli, D., Dominici, C., Nardella, S., Rubino, A. S., De Feo, M., Santini, F., Nicolini, F., ... Biancari, F. (2016). Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery. CIRC J, 81(1), 36-43. https://doi.org/10.1253/circj.CJ-16-0778

Vancouver

Gatti G, Perrotti A, Reichart D, Maschietto L, Onorati F, Chocron S et al. Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery. CIRC J. 2016 Dec 22;81(1):36-43. https://doi.org/10.1253/circj.CJ-16-0778

Bibtex

@article{6e2cc3526dca45f6bb314e83328dea9e,
title = "Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery",
abstract = "BACKGROUND: Glycated hemoglobin (HbA1c) is a suspected risk factor for sternal wound infection (SWI) after CABG.Methods and Results:Data on preoperative HbA1c and SWI were available in 2,130 patients undergoing isolated CABG from the prospective E-CABG registry. SWI occurred in 114 (5.4%). Baseline HbA1c was significantly higher in patients with SWI (mean, 54±17 vs. 45±13 mmol/mol, P<0.0001). This difference was also observed in patients without a diagnosis of diabetes (P=0.027), in insulin-dependent diabetic (P=0.023) and non-insulin-dependent diabetic patients (P=0.034). In the overall series, HbA1c >70 mmol/mol (NGSP units, 8.6%) was associated with the highest risk of SWI (20.6% vs. 4.6%; adjusted OR, 5.01; 95% CI: 2.47-10.15). When dichotomized according to the cut-off 53 mmol/mol (NGSP units, 7.0%) as suggested both for diagnosis and optimal glycemic control of diabetes, HbA1c was associated with increased risk of SWI in the overall series (10.6% vs. 3.9%; adjusted OR, 2.09; 95% CI: 1.24-3.52), in diabetic patients (11.7% vs. 5.1%; adjusted OR, 2.69; 95% CI: 1.38-5.25), in patients undergoing elective surgery (9.9% vs. 2.7%; adjusted OR, 2.09; 95% CI: 1.24-3.52) and in patients with bilateral mammary artery grafts (13.7% vs. 4.8%; adjusted OR, 2.35; 95% CI: 1.17-4.69).CONCLUSIONS: Screening for HbA1c before CABG may identify untreated diabetic patients, as well as diabetic patients with suboptimal glycemic control, at high risk of SWI.",
keywords = "Aged, Coronary Artery Bypass/adverse effects, Diabetes Mellitus/blood, Female, Glycated Hemoglobin A/metabolism, Humans, Male, Middle Aged, Risk Factors, Sternum, Surgical Wound Infection/blood",
author = "Giuseppe Gatti and Andrea Perrotti and Daniel Reichart and Luca Maschietto and Francesco Onorati and Sidney Chocron and Magnus Dal{\'e}n and Peter Svenarud and Giuseppe Faggian and Giuseppe Santarpino and Theodor Fischlein and Aniello Pappalardo and Daniele Maselli and Carmelo Dominici and Saverio Nardella and Rubino, {Antonino S} and {De Feo}, Marisa and Francesco Santini and Francesco Nicolini and Riccardo Gherli and Giovanni Mariscalco and Tuomas Tauriainen and Eeva-Maija Kinnunen and Ruggieri, {Vito G} and Matteo Saccocci and Fausto Biancari",
year = "2016",
month = dec,
day = "22",
doi = "10.1253/circj.CJ-16-0778",
language = "English",
volume = "81",
pages = "36--43",
journal = "CIRC J",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "1",

}

RIS

TY - JOUR

T1 - Glycated Hemoglobin and Risk of Sternal Wound Infection After Isolated Coronary Surgery

AU - Gatti, Giuseppe

AU - Perrotti, Andrea

AU - Reichart, Daniel

AU - Maschietto, Luca

AU - Onorati, Francesco

AU - Chocron, Sidney

AU - Dalén, Magnus

AU - Svenarud, Peter

AU - Faggian, Giuseppe

AU - Santarpino, Giuseppe

AU - Fischlein, Theodor

AU - Pappalardo, Aniello

AU - Maselli, Daniele

AU - Dominici, Carmelo

AU - Nardella, Saverio

AU - Rubino, Antonino S

AU - De Feo, Marisa

AU - Santini, Francesco

AU - Nicolini, Francesco

AU - Gherli, Riccardo

AU - Mariscalco, Giovanni

AU - Tauriainen, Tuomas

AU - Kinnunen, Eeva-Maija

AU - Ruggieri, Vito G

AU - Saccocci, Matteo

AU - Biancari, Fausto

PY - 2016/12/22

Y1 - 2016/12/22

N2 - BACKGROUND: Glycated hemoglobin (HbA1c) is a suspected risk factor for sternal wound infection (SWI) after CABG.Methods and Results:Data on preoperative HbA1c and SWI were available in 2,130 patients undergoing isolated CABG from the prospective E-CABG registry. SWI occurred in 114 (5.4%). Baseline HbA1c was significantly higher in patients with SWI (mean, 54±17 vs. 45±13 mmol/mol, P<0.0001). This difference was also observed in patients without a diagnosis of diabetes (P=0.027), in insulin-dependent diabetic (P=0.023) and non-insulin-dependent diabetic patients (P=0.034). In the overall series, HbA1c >70 mmol/mol (NGSP units, 8.6%) was associated with the highest risk of SWI (20.6% vs. 4.6%; adjusted OR, 5.01; 95% CI: 2.47-10.15). When dichotomized according to the cut-off 53 mmol/mol (NGSP units, 7.0%) as suggested both for diagnosis and optimal glycemic control of diabetes, HbA1c was associated with increased risk of SWI in the overall series (10.6% vs. 3.9%; adjusted OR, 2.09; 95% CI: 1.24-3.52), in diabetic patients (11.7% vs. 5.1%; adjusted OR, 2.69; 95% CI: 1.38-5.25), in patients undergoing elective surgery (9.9% vs. 2.7%; adjusted OR, 2.09; 95% CI: 1.24-3.52) and in patients with bilateral mammary artery grafts (13.7% vs. 4.8%; adjusted OR, 2.35; 95% CI: 1.17-4.69).CONCLUSIONS: Screening for HbA1c before CABG may identify untreated diabetic patients, as well as diabetic patients with suboptimal glycemic control, at high risk of SWI.

AB - BACKGROUND: Glycated hemoglobin (HbA1c) is a suspected risk factor for sternal wound infection (SWI) after CABG.Methods and Results:Data on preoperative HbA1c and SWI were available in 2,130 patients undergoing isolated CABG from the prospective E-CABG registry. SWI occurred in 114 (5.4%). Baseline HbA1c was significantly higher in patients with SWI (mean, 54±17 vs. 45±13 mmol/mol, P<0.0001). This difference was also observed in patients without a diagnosis of diabetes (P=0.027), in insulin-dependent diabetic (P=0.023) and non-insulin-dependent diabetic patients (P=0.034). In the overall series, HbA1c >70 mmol/mol (NGSP units, 8.6%) was associated with the highest risk of SWI (20.6% vs. 4.6%; adjusted OR, 5.01; 95% CI: 2.47-10.15). When dichotomized according to the cut-off 53 mmol/mol (NGSP units, 7.0%) as suggested both for diagnosis and optimal glycemic control of diabetes, HbA1c was associated with increased risk of SWI in the overall series (10.6% vs. 3.9%; adjusted OR, 2.09; 95% CI: 1.24-3.52), in diabetic patients (11.7% vs. 5.1%; adjusted OR, 2.69; 95% CI: 1.38-5.25), in patients undergoing elective surgery (9.9% vs. 2.7%; adjusted OR, 2.09; 95% CI: 1.24-3.52) and in patients with bilateral mammary artery grafts (13.7% vs. 4.8%; adjusted OR, 2.35; 95% CI: 1.17-4.69).CONCLUSIONS: Screening for HbA1c before CABG may identify untreated diabetic patients, as well as diabetic patients with suboptimal glycemic control, at high risk of SWI.

KW - Aged

KW - Coronary Artery Bypass/adverse effects

KW - Diabetes Mellitus/blood

KW - Female

KW - Glycated Hemoglobin A/metabolism

KW - Humans

KW - Male

KW - Middle Aged

KW - Risk Factors

KW - Sternum

KW - Surgical Wound Infection/blood

U2 - 10.1253/circj.CJ-16-0778

DO - 10.1253/circj.CJ-16-0778

M3 - SCORING: Journal article

C2 - 27928145

VL - 81

SP - 36

EP - 43

JO - CIRC J

JF - CIRC J

SN - 1346-9843

IS - 1

ER -