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Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

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Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse. / Ahlbeck, Joachim; Song, Lingzhen; Chini, Mattia; Bitzenhofer, Sebastian H; Hanganu-Opatz, Ileana L.

In: ELIFE, Vol. 7, 10.04.2018, p. e33158.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ahlbeck, J, Song, L, Chini, M, Bitzenhofer, SH & Hanganu-Opatz, IL 2018, 'Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse', ELIFE, vol. 7, pp. e33158. https://doi.org/10.7554/eLife.33158

APA

Ahlbeck, J., Song, L., Chini, M., Bitzenhofer, S. H., & Hanganu-Opatz, I. L. (2018). Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse. ELIFE, 7, e33158. https://doi.org/10.7554/eLife.33158

Vancouver

Ahlbeck J, Song L, Chini M, Bitzenhofer SH, Hanganu-Opatz IL. Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse. ELIFE. 2018 Apr 10;7:e33158. https://doi.org/10.7554/eLife.33158

Bibtex

@article{42f97ad9b81945c5ac2ace45badb6f62,
title = "Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse",
abstract = "The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain.",
keywords = "Journal Article",
author = "Joachim Ahlbeck and Lingzhen Song and Mattia Chini and Bitzenhofer, {Sebastian H} and Hanganu-Opatz, {Ileana L}",
note = "{\textcopyright} 2018, Ahlbeck et al.",
year = "2018",
month = apr,
day = "10",
doi = "10.7554/eLife.33158",
language = "English",
volume = "7",
pages = "e33158",
journal = "ELIFE",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - Glutamatergic drive along the septo-temporal axis of hippocampus boosts prelimbic oscillations in the neonatal mouse

AU - Ahlbeck, Joachim

AU - Song, Lingzhen

AU - Chini, Mattia

AU - Bitzenhofer, Sebastian H

AU - Hanganu-Opatz, Ileana L

N1 - © 2018, Ahlbeck et al.

PY - 2018/4/10

Y1 - 2018/4/10

N2 - The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain.

AB - The long-range coupling within prefrontal-hippocampal networks that account for cognitive performance emerges early in life. The discontinuous hippocampal theta bursts have been proposed to drive the generation of neonatal prefrontal oscillations, yet the cellular substrate of these early interactions is still unresolved. Here, we selectively target optogenetic manipulation of glutamatergic projection neurons in the CA1 area of either dorsal or intermediate/ventral hippocampus at neonatal age to elucidate their contribution to the emergence of prefrontal oscillatory entrainment. We show that despite stronger theta and ripples power in dorsal hippocampus, the prefrontal cortex is mainly coupled with intermediate/ventral hippocampus by phase-locking of neuronal firing via dense direct axonal projections. Theta band-confined activation by light of pyramidal neurons in intermediate/ventral but not dorsal CA1 that were transfected by in utero electroporation with high-efficiency channelrhodopsin boosts prefrontal oscillations. Our data causally elucidate the cellular origin of the long-range coupling in the developing brain.

KW - Journal Article

U2 - 10.7554/eLife.33158

DO - 10.7554/eLife.33158

M3 - SCORING: Journal article

C2 - 29631696

VL - 7

SP - e33158

JO - ELIFE

JF - ELIFE

SN - 2050-084X

ER -