Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
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Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. / Global Cardiovascular Risk Consortium.
In: NEW ENGL J MED, Vol. 389, No. 14, 05.10.2023, p. 1273-1285.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality
AU - Global Cardiovascular Risk Consortium
AU - Magnussen, Christina
AU - Ojeda, Francisco M
AU - Leong, Darryl P
AU - Alegre-Diaz, Jesus
AU - Amouyel, Philippe
AU - Aviles-Santa, Larissa
AU - De Bacquer, Dirk
AU - Ballantyne, Christie M
AU - Bernabé-Ortiz, Antonio
AU - Bobak, Martin
AU - Brenner, Hermann
AU - Carrillo-Larco, Rodrigo M
AU - de Lemos, James
AU - Dobson, Annette
AU - Dörr, Marcus
AU - Donfrancesco, Chiara
AU - Drygas, Wojciech
AU - Dullaart, Robin P
AU - Engström, Gunnar
AU - Ferrario, Marco M
AU - Ferrières, Jean
AU - de Gaetano, Giovanni
AU - Goldbourt, Uri
AU - Gonzalez, Clicerio
AU - Grassi, Guido
AU - Hodge, Allison M
AU - Hveem, Kristian
AU - Iacoviello, Licia
AU - Ikram, M Kamran
AU - Irazola, Vilma
AU - Jobe, Modou
AU - Jousilahti, Pekka
AU - Kaleebu, Pontiano
AU - Kavousi, Maryam
AU - Kee, Frank
AU - Khalili, Davood
AU - Koenig, Wolfgang
AU - Kontsevaya, Anna
AU - Kuulasmaa, Kari
AU - Lackner, Karl J
AU - Leistner, David M
AU - Lind, Lars
AU - Linneberg, Allan
AU - Lorenz, Thiess
AU - Lyngbakken, Magnus Nakrem
AU - Malekzadeh, Reza
AU - Malyutina, Sofia
AU - Mathiesen, Ellisiv B
AU - Melander, Olle
AU - Metspalu, Andres
AU - Miranda, J Jaime
AU - Moitry, Marie
AU - Mugisha, Joseph
AU - Nalini, Mahdi
AU - Nambi, Vijay
AU - Ninomiya, Toshiharu
AU - Oppermann, Karen
AU - d'Orsi, Eleonora
AU - Pająk, Andrzej
AU - Palmieri, Luigi
AU - Panagiotakos, Demosthenes
AU - Perianayagam, Arokiasamy
AU - Peters, Annette
AU - Poustchi, Hossein
AU - Prentice, Andrew M
AU - Prescott, Eva
AU - Risérus, Ulf
AU - Salomaa, Veikko
AU - Sans, Susana
AU - Sakata, Satoko
AU - Schöttker, Ben
AU - Schutte, Aletta E
AU - Sepanlou, Sadaf G
AU - Sharma, Sanjib Kumar
AU - Shaw, Jonathan E
AU - Simons, Leon A
AU - Söderberg, Stefan
AU - Tamosiunas, Abdonas
AU - Thorand, Barbara
AU - Tunstall-Pedoe, Hugh
AU - Twerenbold, Raphael
AU - Vanuzzo, Diego
AU - Veronesi, Giovanni
AU - Waibel, Julia
AU - Wannamethee, S Goya
AU - Watanabe, Masafumi
AU - Wild, Philipp S
AU - Yao, Yao
AU - Zeng, Yi
AU - Ziegler, Andreas
AU - Blankenberg, Stefan
N1 - Copyright © 2023 Massachusetts Medical Society.
PY - 2023/10/5
Y1 - 2023/10/5
N2 - BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).
AB - BACKGROUND: Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.METHODS: We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non-high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.RESULTS: Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).CONCLUSIONS: Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825.).
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Cardiovascular Diseases/epidemiology
KW - Diabetes Mellitus
KW - Risk Factors
KW - Smoking/adverse effects
KW - Heart Disease Risk Factors
KW - Internationality
U2 - 10.1056/NEJMoa2206916
DO - 10.1056/NEJMoa2206916
M3 - SCORING: Journal article
C2 - 37632466
VL - 389
SP - 1273
EP - 1285
JO - NEW ENGL J MED
JF - NEW ENGL J MED
SN - 0028-4793
IS - 14
ER -