Give me A5 for lipoprotein hydrolysis!
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Give me A5 for lipoprotein hydrolysis! / Merkel, Martin; Heeren, Joerg.
In: J CLIN INVEST, Vol. 115, No. 10, 10, 2005, p. 2694-2696.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Give me A5 for lipoprotein hydrolysis!
AU - Merkel, Martin
AU - Heeren, Joerg
PY - 2005
Y1 - 2005
N2 - APOA5 is a newly identified apolipoprotein that plays a crucial role in the regulation of plasma triglyceride levels. In several human studies, common APOA5 single nucleotide polymorphisms have been strongly associated with elevated plasma triglyceride levels. In this issue of the JCI, Marçais et al. report that the rare Q139X mutation in APOA5 leads to severe hypertriglyceridemia by exerting a dominant-negative effect on the plasma lipolytic system for triglyceride-rich lipoproteins. The presented data support the idea that the molecular mechanism of APOA5 function may include the enhancement of binding between lipoproteins and proteoglycans at the vascular wall and activation of proteoglycan-bound lipoprotein lipase.
AB - APOA5 is a newly identified apolipoprotein that plays a crucial role in the regulation of plasma triglyceride levels. In several human studies, common APOA5 single nucleotide polymorphisms have been strongly associated with elevated plasma triglyceride levels. In this issue of the JCI, Marçais et al. report that the rare Q139X mutation in APOA5 leads to severe hypertriglyceridemia by exerting a dominant-negative effect on the plasma lipolytic system for triglyceride-rich lipoproteins. The presented data support the idea that the molecular mechanism of APOA5 function may include the enhancement of binding between lipoproteins and proteoglycans at the vascular wall and activation of proteoglycan-bound lipoprotein lipase.
M3 - SCORING: Zeitschriftenaufsatz
VL - 115
SP - 2694
EP - 2696
JO - J CLIN INVEST
JF - J CLIN INVEST
SN - 0021-9738
IS - 10
M1 - 10
ER -
