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Germline variation at 8q24 and prostate cancer risk in men of European ancestry

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Germline variation at 8q24 and prostate cancer risk in men of European ancestry. / Matejcic, Marco; Saunders, Edward J; Dadaev, Tokhir; Brook, Mark N; Wang, Kan; Sheng, Xin; Olama, Ali Amin Al; Schumacher, Fredrick R; Ingles, Sue A; Govindasami, Koveela; Benlloch, Sara; Berndt, Sonja I; Albanes, Demetrius; Koutros, Stella; Muir, Kenneth; Stevens, Victoria L; Gapstur, Susan M; Tangen, Catherine M; Batra, Jyotsna; Clements, Judith; Gronberg, Henrik; Pashayan, Nora; Schleutker, Johanna; Wolk, Alicja; West, Catharine; Mucci, Lorelei; Kraft, Peter; Cancel-Tassin, Géraldine; Sorensen, Karina D; Maehle, Lovise; Grindedal, Eli M; Strom, Sara S; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Travis, Ruth C; Hamilton, Robert J; Rosenstein, Barry; Lu, Yong-Jie; Giles, Graham G; Kibel, Adam S; Vega, Ana; Bensen, Jeanette T; Kogevinas, Manolis; Penney, Kathryn L; Park, Jong Y; Stanford, Janet L; Cybulski, Cezary; Nordestgaard, Børge G; Brenner, Hermann; Maier, Christiane; Kim, Jeri; Teixeira, Manuel R; Neuhausen, Susan L; De Ruyck, Kim; Razack, Azad; Newcomb, Lisa F; Lessel, Davor; Kaneva, Radka; Usmani, Nawaid; Claessens, Frank; Townsend, Paul A; Dominguez, Manuela G; Roobol, Monique J; Menegaux, Florence; Khaw, Kay-Tee; Cannon-Albright, Lisa A; Pandha, Hardev; Thibodeau, Stephen N; Schaid, Daniel J; Wiklund, Fredrik; Chanock, Stephen J; Easton, Douglas F; Eeles, Rosalind A; Kote-Jarai, Zsofia; Conti, David V; Haiman, Christopher A; PRACTICAL Consortium.

In: NAT COMMUN, Vol. 9, No. 1, 05.11.2018, p. 4616.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Matejcic, M, Saunders, EJ, Dadaev, T, Brook, MN, Wang, K, Sheng, X, Olama, AAA, Schumacher, FR, Ingles, SA, Govindasami, K, Benlloch, S, Berndt, SI, Albanes, D, Koutros, S, Muir, K, Stevens, VL, Gapstur, SM, Tangen, CM, Batra, J, Clements, J, Gronberg, H, Pashayan, N, Schleutker, J, Wolk, A, West, C, Mucci, L, Kraft, P, Cancel-Tassin, G, Sorensen, KD, Maehle, L, Grindedal, EM, Strom, SS, Neal, DE, Hamdy, FC, Donovan, JL, Travis, RC, Hamilton, RJ, Rosenstein, B, Lu, Y-J, Giles, GG, Kibel, AS, Vega, A, Bensen, JT, Kogevinas, M, Penney, KL, Park, JY, Stanford, JL, Cybulski, C, Nordestgaard, BG, Brenner, H, Maier, C, Kim, J, Teixeira, MR, Neuhausen, SL, De Ruyck, K, Razack, A, Newcomb, LF, Lessel, D, Kaneva, R, Usmani, N, Claessens, F, Townsend, PA, Dominguez, MG, Roobol, MJ, Menegaux, F, Khaw, K-T, Cannon-Albright, LA, Pandha, H, Thibodeau, SN, Schaid, DJ, Wiklund, F, Chanock, SJ, Easton, DF, Eeles, RA, Kote-Jarai, Z, Conti, DV, Haiman, CA & PRACTICAL Consortium 2018, 'Germline variation at 8q24 and prostate cancer risk in men of European ancestry', NAT COMMUN, vol. 9, no. 1, pp. 4616. https://doi.org/10.1038/s41467-018-06863-1

APA

Matejcic, M., Saunders, E. J., Dadaev, T., Brook, M. N., Wang, K., Sheng, X., Olama, A. A. A., Schumacher, F. R., Ingles, S. A., Govindasami, K., Benlloch, S., Berndt, S. I., Albanes, D., Koutros, S., Muir, K., Stevens, V. L., Gapstur, S. M., Tangen, C. M., Batra, J., ... PRACTICAL Consortium (2018). Germline variation at 8q24 and prostate cancer risk in men of European ancestry. NAT COMMUN, 9(1), 4616. https://doi.org/10.1038/s41467-018-06863-1

Vancouver

Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X et al. Germline variation at 8q24 and prostate cancer risk in men of European ancestry. NAT COMMUN. 2018 Nov 5;9(1):4616. https://doi.org/10.1038/s41467-018-06863-1

Bibtex

@article{37ac1aa11f6d4ba9b362c63041c25233,
title = "Germline variation at 8q24 and prostate cancer risk in men of European ancestry",
abstract = "Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.",
keywords = "Journal Article",
author = "Marco Matejcic and Saunders, {Edward J} and Tokhir Dadaev and Brook, {Mark N} and Kan Wang and Xin Sheng and Olama, {Ali Amin Al} and Schumacher, {Fredrick R} and Ingles, {Sue A} and Koveela Govindasami and Sara Benlloch and Berndt, {Sonja I} and Demetrius Albanes and Stella Koutros and Kenneth Muir and Stevens, {Victoria L} and Gapstur, {Susan M} and Tangen, {Catherine M} and Jyotsna Batra and Judith Clements and Henrik Gronberg and Nora Pashayan and Johanna Schleutker and Alicja Wolk and Catharine West and Lorelei Mucci and Peter Kraft and G{\'e}raldine Cancel-Tassin and Sorensen, {Karina D} and Lovise Maehle and Grindedal, {Eli M} and Strom, {Sara S} and Neal, {David E} and Hamdy, {Freddie C} and Donovan, {Jenny L} and Travis, {Ruth C} and Hamilton, {Robert J} and Barry Rosenstein and Yong-Jie Lu and Giles, {Graham G} and Kibel, {Adam S} and Ana Vega and Bensen, {Jeanette T} and Manolis Kogevinas and Penney, {Kathryn L} and Park, {Jong Y} and Stanford, {Janet L} and Cezary Cybulski and Nordestgaard, {B{\o}rge G} and Hermann Brenner and Christiane Maier and Jeri Kim and Teixeira, {Manuel R} and Neuhausen, {Susan L} and {De Ruyck}, Kim and Azad Razack and Newcomb, {Lisa F} and Davor Lessel and Radka Kaneva and Nawaid Usmani and Frank Claessens and Townsend, {Paul A} and Dominguez, {Manuela G} and Roobol, {Monique J} and Florence Menegaux and Kay-Tee Khaw and Cannon-Albright, {Lisa A} and Hardev Pandha and Thibodeau, {Stephen N} and Schaid, {Daniel J} and Fredrik Wiklund and Chanock, {Stephen J} and Easton, {Douglas F} and Eeles, {Rosalind A} and Zsofia Kote-Jarai and Conti, {David V} and Haiman, {Christopher A} and {PRACTICAL Consortium}",
year = "2018",
month = nov,
day = "5",
doi = "10.1038/s41467-018-06863-1",
language = "English",
volume = "9",
pages = "4616",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Germline variation at 8q24 and prostate cancer risk in men of European ancestry

AU - Matejcic, Marco

AU - Saunders, Edward J

AU - Dadaev, Tokhir

AU - Brook, Mark N

AU - Wang, Kan

AU - Sheng, Xin

AU - Olama, Ali Amin Al

AU - Schumacher, Fredrick R

AU - Ingles, Sue A

AU - Govindasami, Koveela

AU - Benlloch, Sara

AU - Berndt, Sonja I

AU - Albanes, Demetrius

AU - Koutros, Stella

AU - Muir, Kenneth

AU - Stevens, Victoria L

AU - Gapstur, Susan M

AU - Tangen, Catherine M

AU - Batra, Jyotsna

AU - Clements, Judith

AU - Gronberg, Henrik

AU - Pashayan, Nora

AU - Schleutker, Johanna

AU - Wolk, Alicja

AU - West, Catharine

AU - Mucci, Lorelei

AU - Kraft, Peter

AU - Cancel-Tassin, Géraldine

AU - Sorensen, Karina D

AU - Maehle, Lovise

AU - Grindedal, Eli M

AU - Strom, Sara S

AU - Neal, David E

AU - Hamdy, Freddie C

AU - Donovan, Jenny L

AU - Travis, Ruth C

AU - Hamilton, Robert J

AU - Rosenstein, Barry

AU - Lu, Yong-Jie

AU - Giles, Graham G

AU - Kibel, Adam S

AU - Vega, Ana

AU - Bensen, Jeanette T

AU - Kogevinas, Manolis

AU - Penney, Kathryn L

AU - Park, Jong Y

AU - Stanford, Janet L

AU - Cybulski, Cezary

AU - Nordestgaard, Børge G

AU - Brenner, Hermann

AU - Maier, Christiane

AU - Kim, Jeri

AU - Teixeira, Manuel R

AU - Neuhausen, Susan L

AU - De Ruyck, Kim

AU - Razack, Azad

AU - Newcomb, Lisa F

AU - Lessel, Davor

AU - Kaneva, Radka

AU - Usmani, Nawaid

AU - Claessens, Frank

AU - Townsend, Paul A

AU - Dominguez, Manuela G

AU - Roobol, Monique J

AU - Menegaux, Florence

AU - Khaw, Kay-Tee

AU - Cannon-Albright, Lisa A

AU - Pandha, Hardev

AU - Thibodeau, Stephen N

AU - Schaid, Daniel J

AU - Wiklund, Fredrik

AU - Chanock, Stephen J

AU - Easton, Douglas F

AU - Eeles, Rosalind A

AU - Kote-Jarai, Zsofia

AU - Conti, David V

AU - Haiman, Christopher A

AU - PRACTICAL Consortium

PY - 2018/11/5

Y1 - 2018/11/5

N2 - Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

AB - Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10-15), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.

KW - Journal Article

U2 - 10.1038/s41467-018-06863-1

DO - 10.1038/s41467-018-06863-1

M3 - SCORING: Journal article

C2 - 30397198

VL - 9

SP - 4616

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -