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Germ cell lineage differentiation in non-seminomatous germ cell tumours

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Germ cell lineage differentiation in non-seminomatous germ cell tumours. / Honecker, Friedemann; Stoop, Hans; Mayer, Frank; Bokemeyer, Carsten; Castrillon, Diego H; Lau, Yun-Fai Chris; Looijenga, Leendert H J; Oosterhuis, J Wolter.

In: J PATHOL, Vol. 208, No. 3, 02.2006, p. 395-400.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Honecker, F, Stoop, H, Mayer, F, Bokemeyer, C, Castrillon, DH, Lau, Y-FC, Looijenga, LHJ & Oosterhuis, JW 2006, 'Germ cell lineage differentiation in non-seminomatous germ cell tumours', J PATHOL, vol. 208, no. 3, pp. 395-400. https://doi.org/10.1002/path.1872

APA

Honecker, F., Stoop, H., Mayer, F., Bokemeyer, C., Castrillon, D. H., Lau, Y-F. C., Looijenga, L. H. J., & Oosterhuis, J. W. (2006). Germ cell lineage differentiation in non-seminomatous germ cell tumours. J PATHOL, 208(3), 395-400. https://doi.org/10.1002/path.1872

Vancouver

Honecker F, Stoop H, Mayer F, Bokemeyer C, Castrillon DH, Lau Y-FC et al. Germ cell lineage differentiation in non-seminomatous germ cell tumours. J PATHOL. 2006 Feb;208(3):395-400. https://doi.org/10.1002/path.1872

Bibtex

@article{a43bf0dc99394c87acdc7bdff36cd31b,
title = "Germ cell lineage differentiation in non-seminomatous germ cell tumours",
abstract = "Human germ cell tumours (GCTs) have long fascinated investigators for a number of reasons. Being pluripotential tumours, they can differentiate into both extra-embryonic and embryonic (somatic) tissues. However, it has never been shown convincingly that, in humans, these tumours are truly totipotent and can also give rise to the germ lineage, the third major differentiation lineage occurring early during embryonic life. Using a number of newly available, distinct, immunohistochemical markers, such as OCT3/4, VASA and TSPY, the occurrence of germ cells was investigated in a number of germ cell tumours. Development of germ cells was identified in three independent non-seminomas, including two pure yolk sac tumours and one mixed tumour composed of yolk sac tumour and immature teratoma. Our finding indicates a previously unknown totipotent potential of human GCTs and raises the question of whether, under certain culture conditions, primordial germ cells could be derived from human GCT cell lines.",
keywords = "Biological Markers, Cell Differentiation, Cell Lineage, Endodermal Sinus Tumor, Female, Germ Cells, Humans, Immunohistochemistry, Male, Neoplasms, Germ Cell and Embryonal, Pluripotent Stem Cells, Stem Cells, Teratoma, Totipotent Stem Cells",
author = "Friedemann Honecker and Hans Stoop and Frank Mayer and Carsten Bokemeyer and Castrillon, {Diego H} and Lau, {Yun-Fai Chris} and Looijenga, {Leendert H J} and Oosterhuis, {J Wolter}",
year = "2006",
month = feb,
doi = "10.1002/path.1872",
language = "English",
volume = "208",
pages = "395--400",
journal = "J PATHOL",
issn = "0022-3417",
publisher = "John Wiley and Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Germ cell lineage differentiation in non-seminomatous germ cell tumours

AU - Honecker, Friedemann

AU - Stoop, Hans

AU - Mayer, Frank

AU - Bokemeyer, Carsten

AU - Castrillon, Diego H

AU - Lau, Yun-Fai Chris

AU - Looijenga, Leendert H J

AU - Oosterhuis, J Wolter

PY - 2006/2

Y1 - 2006/2

N2 - Human germ cell tumours (GCTs) have long fascinated investigators for a number of reasons. Being pluripotential tumours, they can differentiate into both extra-embryonic and embryonic (somatic) tissues. However, it has never been shown convincingly that, in humans, these tumours are truly totipotent and can also give rise to the germ lineage, the third major differentiation lineage occurring early during embryonic life. Using a number of newly available, distinct, immunohistochemical markers, such as OCT3/4, VASA and TSPY, the occurrence of germ cells was investigated in a number of germ cell tumours. Development of germ cells was identified in three independent non-seminomas, including two pure yolk sac tumours and one mixed tumour composed of yolk sac tumour and immature teratoma. Our finding indicates a previously unknown totipotent potential of human GCTs and raises the question of whether, under certain culture conditions, primordial germ cells could be derived from human GCT cell lines.

AB - Human germ cell tumours (GCTs) have long fascinated investigators for a number of reasons. Being pluripotential tumours, they can differentiate into both extra-embryonic and embryonic (somatic) tissues. However, it has never been shown convincingly that, in humans, these tumours are truly totipotent and can also give rise to the germ lineage, the third major differentiation lineage occurring early during embryonic life. Using a number of newly available, distinct, immunohistochemical markers, such as OCT3/4, VASA and TSPY, the occurrence of germ cells was investigated in a number of germ cell tumours. Development of germ cells was identified in three independent non-seminomas, including two pure yolk sac tumours and one mixed tumour composed of yolk sac tumour and immature teratoma. Our finding indicates a previously unknown totipotent potential of human GCTs and raises the question of whether, under certain culture conditions, primordial germ cells could be derived from human GCT cell lines.

KW - Biological Markers

KW - Cell Differentiation

KW - Cell Lineage

KW - Endodermal Sinus Tumor

KW - Female

KW - Germ Cells

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Neoplasms, Germ Cell and Embryonal

KW - Pluripotent Stem Cells

KW - Stem Cells

KW - Teratoma

KW - Totipotent Stem Cells

U2 - 10.1002/path.1872

DO - 10.1002/path.1872

M3 - SCORING: Journal article

C2 - 16273510

VL - 208

SP - 395

EP - 400

JO - J PATHOL

JF - J PATHOL

SN - 0022-3417

IS - 3

ER -