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Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany

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Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. / Quabius, Elgar Susanne; Haag, Jochen; Kühnel, André; Henry, Hannes; Hoffmann, Anna Sophie; Görögh, Tibor; Hedderich, Jürgen; Evert, Matthias; Beule, Achim G; Maune, Steffen; Knecht, Rainald; Óvári, Attila; Durisin, Martin; Hoppe, Florian; Tribius, Silke; Röcken, Christoph; Ambrosch, Petra; Hoffmann, Markus.

In: INT J ONCOL, Vol. 46, No. 1, 01.01.2015, p. 414-22.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Quabius, ES, Haag, J, Kühnel, A, Henry, H, Hoffmann, AS, Görögh, T, Hedderich, J, Evert, M, Beule, AG, Maune, S, Knecht, R, Óvári, A, Durisin, M, Hoppe, F, Tribius, S, Röcken, C, Ambrosch, P & Hoffmann, M 2015, 'Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany', INT J ONCOL, vol. 46, no. 1, pp. 414-22. https://doi.org/10.3892/ijo.2014.2697

APA

Quabius, E. S., Haag, J., Kühnel, A., Henry, H., Hoffmann, A. S., Görögh, T., Hedderich, J., Evert, M., Beule, A. G., Maune, S., Knecht, R., Óvári, A., Durisin, M., Hoppe, F., Tribius, S., Röcken, C., Ambrosch, P., & Hoffmann, M. (2015). Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. INT J ONCOL, 46(1), 414-22. https://doi.org/10.3892/ijo.2014.2697

Vancouver

Quabius ES, Haag J, Kühnel A, Henry H, Hoffmann AS, Görögh T et al. Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany. INT J ONCOL. 2015 Jan 1;46(1):414-22. https://doi.org/10.3892/ijo.2014.2697

Bibtex

@article{f905a245271b4b24941181f80334eedd,
title = "Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany",
abstract = "The increased knowledge regarding HPV-infections in head and neck squamous cell carcinoma (HNSCC) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on tumour site and geographical origin of the patients, ii) proportion of HPV-driven tumours among HPV-DNA-positive cases, and iii) identification of patients with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 HNSCC cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and p16INK4A-status and combined results with the patient outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non-tonsillar SCC were HPV-mRNA-positive. Although the study cohort was composed of patients from regions of rather close proximity, prevalence rates showed diversities of up to 40% in HNSCC subsite analysis with the lowest prevalence for tonsillar SCC in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified p16INK4A alone as strongest predictor, followed by HPV-DNA-status alone or in combination with p16INK4A. This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on HPV-infection in HNSCC to, e.g. clarify to what extent survival benefits of p16INK4A-positive patients are truly attributed to HPV-infections.",
author = "Quabius, {Elgar Susanne} and Jochen Haag and Andr{\'e} K{\"u}hnel and Hannes Henry and Hoffmann, {Anna Sophie} and Tibor G{\"o}r{\"o}gh and J{\"u}rgen Hedderich and Matthias Evert and Beule, {Achim G} and Steffen Maune and Rainald Knecht and Attila {\'O}v{\'a}ri and Martin Durisin and Florian Hoppe and Silke Tribius and Christoph R{\"o}cken and Petra Ambrosch and Markus Hoffmann",
year = "2015",
month = jan,
day = "1",
doi = "10.3892/ijo.2014.2697",
language = "English",
volume = "46",
pages = "414--22",
journal = "INT J ONCOL",
issn = "1019-6439",
publisher = "Spandidos Publications",
number = "1",

}

RIS

TY - JOUR

T1 - Geographical and anatomical influences on human papillomavirus prevalence diversity in head and neck squamous cell carcinoma in Germany

AU - Quabius, Elgar Susanne

AU - Haag, Jochen

AU - Kühnel, André

AU - Henry, Hannes

AU - Hoffmann, Anna Sophie

AU - Görögh, Tibor

AU - Hedderich, Jürgen

AU - Evert, Matthias

AU - Beule, Achim G

AU - Maune, Steffen

AU - Knecht, Rainald

AU - Óvári, Attila

AU - Durisin, Martin

AU - Hoppe, Florian

AU - Tribius, Silke

AU - Röcken, Christoph

AU - Ambrosch, Petra

AU - Hoffmann, Markus

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The increased knowledge regarding HPV-infections in head and neck squamous cell carcinoma (HNSCC) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on tumour site and geographical origin of the patients, ii) proportion of HPV-driven tumours among HPV-DNA-positive cases, and iii) identification of patients with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 HNSCC cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and p16INK4A-status and combined results with the patient outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non-tonsillar SCC were HPV-mRNA-positive. Although the study cohort was composed of patients from regions of rather close proximity, prevalence rates showed diversities of up to 40% in HNSCC subsite analysis with the lowest prevalence for tonsillar SCC in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified p16INK4A alone as strongest predictor, followed by HPV-DNA-status alone or in combination with p16INK4A. This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on HPV-infection in HNSCC to, e.g. clarify to what extent survival benefits of p16INK4A-positive patients are truly attributed to HPV-infections.

AB - The increased knowledge regarding HPV-infections in head and neck squamous cell carcinoma (HNSCC) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on tumour site and geographical origin of the patients, ii) proportion of HPV-driven tumours among HPV-DNA-positive cases, and iii) identification of patients with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 HNSCC cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and p16INK4A-status and combined results with the patient outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non-tonsillar SCC were HPV-mRNA-positive. Although the study cohort was composed of patients from regions of rather close proximity, prevalence rates showed diversities of up to 40% in HNSCC subsite analysis with the lowest prevalence for tonsillar SCC in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified p16INK4A alone as strongest predictor, followed by HPV-DNA-status alone or in combination with p16INK4A. This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on HPV-infection in HNSCC to, e.g. clarify to what extent survival benefits of p16INK4A-positive patients are truly attributed to HPV-infections.

U2 - 10.3892/ijo.2014.2697

DO - 10.3892/ijo.2014.2697

M3 - SCORING: Journal article

C2 - 25310104

VL - 46

SP - 414

EP - 422

JO - INT J ONCOL

JF - INT J ONCOL

SN - 1019-6439

IS - 1

ER -