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Genomic architecture of human neuroanatomical diversity

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Genomic architecture of human neuroanatomical diversity. / Toro, R; Poline, J-B; Huguet, G; Loth, E; Frouin, V; Banaschewski, T; Barker, G J; Bokde, A; Büchel, C; Carvalho, F M; Conrod, P; Fauth-Bühler, M; Flor, H; Gallinat, J; Garavan, H; Gowland, P; Heinz, A; Ittermann, B; Lawrence, C; Lemaître, H; Mann, K; Nees, F; Paus, T; Pausova, Z; Rietschel, M; Robbins, T; Smolka, M N; Ströhle, A; Schumann, G; Bourgeron, T.

In: MOL PSYCHIATR, Vol. 20, No. 8, 08.2015, p. 1011-1016.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Toro, R, Poline, J-B, Huguet, G, Loth, E, Frouin, V, Banaschewski, T, Barker, GJ, Bokde, A, Büchel, C, Carvalho, FM, Conrod, P, Fauth-Bühler, M, Flor, H, Gallinat, J, Garavan, H, Gowland, P, Heinz, A, Ittermann, B, Lawrence, C, Lemaître, H, Mann, K, Nees, F, Paus, T, Pausova, Z, Rietschel, M, Robbins, T, Smolka, MN, Ströhle, A, Schumann, G & Bourgeron, T 2015, 'Genomic architecture of human neuroanatomical diversity', MOL PSYCHIATR, vol. 20, no. 8, pp. 1011-1016. https://doi.org/10.1038/mp.2014.99

APA

Toro, R., Poline, J-B., Huguet, G., Loth, E., Frouin, V., Banaschewski, T., Barker, G. J., Bokde, A., Büchel, C., Carvalho, F. M., Conrod, P., Fauth-Bühler, M., Flor, H., Gallinat, J., Garavan, H., Gowland, P., Heinz, A., Ittermann, B., Lawrence, C., ... Bourgeron, T. (2015). Genomic architecture of human neuroanatomical diversity. MOL PSYCHIATR, 20(8), 1011-1016. https://doi.org/10.1038/mp.2014.99

Vancouver

Toro R, Poline J-B, Huguet G, Loth E, Frouin V, Banaschewski T et al. Genomic architecture of human neuroanatomical diversity. MOL PSYCHIATR. 2015 Aug;20(8):1011-1016. https://doi.org/10.1038/mp.2014.99

Bibtex

@article{c8d02ae62cec44f281544c17120c677d,
title = "Genomic architecture of human neuroanatomical diversity",
abstract = "Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.Molecular Psychiatry advance online publication, 16 September 2014; doi:10.1038/mp.2014.99.",
author = "R Toro and J-B Poline and G Huguet and E Loth and V Frouin and T Banaschewski and Barker, {G J} and A Bokde and C B{\"u}chel and Carvalho, {F M} and P Conrod and M Fauth-B{\"u}hler and H Flor and J Gallinat and H Garavan and P Gowland and A Heinz and B Ittermann and C Lawrence and H Lema{\^i}tre and K Mann and F Nees and T Paus and Z Pausova and M Rietschel and T Robbins and Smolka, {M N} and A Str{\"o}hle and G Schumann and T Bourgeron",
year = "2015",
month = aug,
doi = "10.1038/mp.2014.99",
language = "English",
volume = "20",
pages = "1011--1016",
journal = "MOL PSYCHIATR",
issn = "1359-4184",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Genomic architecture of human neuroanatomical diversity

AU - Toro, R

AU - Poline, J-B

AU - Huguet, G

AU - Loth, E

AU - Frouin, V

AU - Banaschewski, T

AU - Barker, G J

AU - Bokde, A

AU - Büchel, C

AU - Carvalho, F M

AU - Conrod, P

AU - Fauth-Bühler, M

AU - Flor, H

AU - Gallinat, J

AU - Garavan, H

AU - Gowland, P

AU - Heinz, A

AU - Ittermann, B

AU - Lawrence, C

AU - Lemaître, H

AU - Mann, K

AU - Nees, F

AU - Paus, T

AU - Pausova, Z

AU - Rietschel, M

AU - Robbins, T

AU - Smolka, M N

AU - Ströhle, A

AU - Schumann, G

AU - Bourgeron, T

PY - 2015/8

Y1 - 2015/8

N2 - Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.Molecular Psychiatry advance online publication, 16 September 2014; doi:10.1038/mp.2014.99.

AB - Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.Molecular Psychiatry advance online publication, 16 September 2014; doi:10.1038/mp.2014.99.

U2 - 10.1038/mp.2014.99

DO - 10.1038/mp.2014.99

M3 - SCORING: Journal article

C2 - 25224261

VL - 20

SP - 1011

EP - 1016

JO - MOL PSYCHIATR

JF - MOL PSYCHIATR

SN - 1359-4184

IS - 8

ER -