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Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.

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Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. / Hillmer, Axel M; Flaquer, Antonia; Hanneken, Sandra; Eigelshoven, Sibylle; Kortüm, Anne-Katrin; Brockschmidt, Felix F; Golla, Astrid; Metzen, Christine; Thiele, Holger; Kolberg, Susanne; Reinartz, Roman; Betz, Regina C; Ruzicka, Thomas; Hennies, Hans Christian; Kruse, Roland; Nöthen, Markus M.

In: AM J HUM GENET, Vol. 82, No. 3, 3, 2008, p. 737-743.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Hillmer, AM, Flaquer, A, Hanneken, S, Eigelshoven, S, Kortüm, A-K, Brockschmidt, FF, Golla, A, Metzen, C, Thiele, H, Kolberg, S, Reinartz, R, Betz, RC, Ruzicka, T, Hennies, HC, Kruse, R & Nöthen, MM 2008, 'Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.', AM J HUM GENET, vol. 82, no. 3, 3, pp. 737-743. <http://www.ncbi.nlm.nih.gov/pubmed/18304493?dopt=Citation>

APA

Hillmer, A. M., Flaquer, A., Hanneken, S., Eigelshoven, S., Kortüm, A-K., Brockschmidt, F. F., Golla, A., Metzen, C., Thiele, H., Kolberg, S., Reinartz, R., Betz, R. C., Ruzicka, T., Hennies, H. C., Kruse, R., & Nöthen, M. M. (2008). Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. AM J HUM GENET, 82(3), 737-743. [3]. http://www.ncbi.nlm.nih.gov/pubmed/18304493?dopt=Citation

Vancouver

Hillmer AM, Flaquer A, Hanneken S, Eigelshoven S, Kortüm A-K, Brockschmidt FF et al. Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26. AM J HUM GENET. 2008;82(3):737-743. 3.

Bibtex

@article{023dc0533c0741578121180dea31ae70,
title = "Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.",
abstract = "Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.",
author = "Hillmer, {Axel M} and Antonia Flaquer and Sandra Hanneken and Sibylle Eigelshoven and Anne-Katrin Kort{\"u}m and Brockschmidt, {Felix F} and Astrid Golla and Christine Metzen and Holger Thiele and Susanne Kolberg and Roman Reinartz and Betz, {Regina C} and Thomas Ruzicka and Hennies, {Hans Christian} and Roland Kruse and N{\"o}then, {Markus M}",
year = "2008",
language = "Deutsch",
volume = "82",
pages = "737--743",
journal = "AM J HUM GENET",
issn = "0002-9297",
publisher = "Cell Press",
number = "3",

}

RIS

TY - JOUR

T1 - Genome-wide scan and fine-mapping linkage study of androgenetic alopecia reveals a locus on chromosome 3q26.

AU - Hillmer, Axel M

AU - Flaquer, Antonia

AU - Hanneken, Sandra

AU - Eigelshoven, Sibylle

AU - Kortüm, Anne-Katrin

AU - Brockschmidt, Felix F

AU - Golla, Astrid

AU - Metzen, Christine

AU - Thiele, Holger

AU - Kolberg, Susanne

AU - Reinartz, Roman

AU - Betz, Regina C

AU - Ruzicka, Thomas

AU - Hennies, Hans Christian

AU - Kruse, Roland

AU - Nöthen, Markus M

PY - 2008

Y1 - 2008

N2 - Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

AB - Androgenetic alopecia (AGA, male pattern baldness) is the most common form of hair loss. The origin of AGA is genetic, with the X chromosome located androgen receptor gene (AR) being the only risk gene identified to date. We present the results of a genome-wide linkage study of 95 families and linkage fine mapping of the 3q21-q29, 11q14-q25, 18p11-q23, and 19p13-q13 regions in an extended sample of 125 families of German descent. The locus with strongest evidence for linkage was mapped to 3q26 with a nonparametric linkage (NPL) score of 3.97 (empirical p value = 0.00055). This is the first step toward the identification of new susceptibility genes in AGA, a process which will provide important insights into the molecular and cellular basis of scalp hair loss.

M3 - SCORING: Zeitschriftenaufsatz

VL - 82

SP - 737

EP - 743

JO - AM J HUM GENET

JF - AM J HUM GENET

SN - 0002-9297

IS - 3

M1 - 3

ER -