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Genome-wide meta-analysis identifies new susceptibility loci for migraine

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Genome-wide meta-analysis identifies new susceptibility loci for migraine. / Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimäki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho; Dunham, Ian; Neale, Benjamin M; Palta, Priit; Hamalainen, Eija; Schürks, Markus; Rose, Lynda M; Buring, Julie E; Ridker, Paul M; Steinberg, Stacy; Stefansson, Hreinn; Jakobsson, Finnbogi; Lawlor, Debbie A; Evans, David M; Ring, Susan M; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari A; Freilinger, Tobias; Schoenen, Jean; Frants, Rune R; Pelzer, Nadine; Weller, Claudia M; Zielman, Ronald; Heath, Andrew C; Madden, Pamela A F; Montgomery, Grant W; Martin, Nicholas G; Borck, Guntram; Göbel, Hartmut; Heinze, Axel; Heinze-Kuhn, Katja; Williams, Frances M K; Hartikainen, Anna-Liisa; Pouta, Anneli; van den Ende, Joyce; Uitterlinden, Andre G; Hofman, Albert; Amin, Najaf; Hottenga, Jouke-Jan; Vink, Jacqueline M; Heikkilä, Kauko; Alexander, Michael; Muller-Myhsok, Bertram; Schreiber, Stefan; Meitinger, Thomas; Wichmann, Heinz Erich; Aromaa, Arpo; Eriksson, Johan G; Traynor, Bryan J; Trabzuni, Daniah; Rossin, Elizabeth; Lage, Kasper; Jacobs, Suzanne B R; Gibbs, J Raphael; Birney, Ewan; Kaprio, Jaakko; Penninx, Brenda W; Boomsma, Dorret I; van Duijn, Cornelia; Raitakari, Olli; Jarvelin, Marjo-Riitta; Zwart, John-Anker; Cherkas, Lynn; Strachan, David P; Kubisch, Christian; Ferrari, Michel D; van den Maagdenberg, Arn M J M; Dichgans, Martin; Wessman, Maija; Smith, George Davey; Stefansson, Kari; Daly, Mark J; Nyholt, Dale R; Chasman, Daniel I; Palotie, Aarno; North American Brain Expression Consortium.

In: NAT GENET, Vol. 45, No. 8, 01.08.2013, p. 912-7.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Anttila, V, Winsvold, BS, Gormley, P, Kurth, T, Bettella, F, McMahon, G, Kallela, M, Malik, R, de Vries, B, Terwindt, G, Medland, SE, Todt, U, McArdle, WL, Quaye, L, Koiranen, M, Ikram, MA, Lehtimäki, T, Stam, AH, Ligthart, L, Wedenoja, J, Dunham, I, Neale, BM, Palta, P, Hamalainen, E, Schürks, M, Rose, LM, Buring, JE, Ridker, PM, Steinberg, S, Stefansson, H, Jakobsson, F, Lawlor, DA, Evans, DM, Ring, SM, Färkkilä, M, Artto, V, Kaunisto, MA, Freilinger, T, Schoenen, J, Frants, RR, Pelzer, N, Weller, CM, Zielman, R, Heath, AC, Madden, PAF, Montgomery, GW, Martin, NG, Borck, G, Göbel, H, Heinze, A, Heinze-Kuhn, K, Williams, FMK, Hartikainen, A-L, Pouta, A, van den Ende, J, Uitterlinden, AG, Hofman, A, Amin, N, Hottenga, J-J, Vink, JM, Heikkilä, K, Alexander, M, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Wichmann, HE, Aromaa, A, Eriksson, JG, Traynor, BJ, Trabzuni, D, Rossin, E, Lage, K, Jacobs, SBR, Gibbs, JR, Birney, E, Kaprio, J, Penninx, BW, Boomsma, DI, van Duijn, C, Raitakari, O, Jarvelin, M-R, Zwart, J-A, Cherkas, L, Strachan, DP, Kubisch, C, Ferrari, MD, van den Maagdenberg, AMJM, Dichgans, M, Wessman, M, Smith, GD, Stefansson, K, Daly, MJ, Nyholt, DR, Chasman, DI, Palotie, A & North American Brain Expression Consortium 2013, 'Genome-wide meta-analysis identifies new susceptibility loci for migraine', NAT GENET, vol. 45, no. 8, pp. 912-7. https://doi.org/10.1038/ng.2676

APA

Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, L., ... North American Brain Expression Consortium (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. NAT GENET, 45(8), 912-7. https://doi.org/10.1038/ng.2676

Vancouver

Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G et al. Genome-wide meta-analysis identifies new susceptibility loci for migraine. NAT GENET. 2013 Aug 1;45(8):912-7. https://doi.org/10.1038/ng.2676

Bibtex

@article{e49e453f80d7496299dcae006249eb0e,
title = "Genome-wide meta-analysis identifies new susceptibility loci for migraine",
abstract = "Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.",
keywords = "Cerebellum, Computational Biology, Frontal Lobe, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Migraine Disorders, Polymorphism, Single Nucleotide, Quantitative Trait Loci",
author = "Verneri Anttila and Winsvold, {Bendik S} and Padhraig Gormley and Tobias Kurth and Francesco Bettella and George McMahon and Mikko Kallela and Rainer Malik and {de Vries}, Boukje and Gisela Terwindt and Medland, {Sarah E} and Unda Todt and McArdle, {Wendy L} and Lydia Quaye and Markku Koiranen and Ikram, {M Arfan} and Terho Lehtim{\"a}ki and Stam, {Anine H} and Lannie Ligthart and Juho Wedenoja and Ian Dunham and Neale, {Benjamin M} and Priit Palta and Eija Hamalainen and Markus Sch{\"u}rks and Rose, {Lynda M} and Buring, {Julie E} and Ridker, {Paul M} and Stacy Steinberg and Hreinn Stefansson and Finnbogi Jakobsson and Lawlor, {Debbie A} and Evans, {David M} and Ring, {Susan M} and Markus F{\"a}rkkil{\"a} and Ville Artto and Kaunisto, {Mari A} and Tobias Freilinger and Jean Schoenen and Frants, {Rune R} and Nadine Pelzer and Weller, {Claudia M} and Ronald Zielman and Heath, {Andrew C} and Madden, {Pamela A F} and Montgomery, {Grant W} and Martin, {Nicholas G} and Guntram Borck and Hartmut G{\"o}bel and Axel Heinze and Katja Heinze-Kuhn and Williams, {Frances M K} and Anna-Liisa Hartikainen and Anneli Pouta and {van den Ende}, Joyce and Uitterlinden, {Andre G} and Albert Hofman and Najaf Amin and Jouke-Jan Hottenga and Vink, {Jacqueline M} and Kauko Heikkil{\"a} and Michael Alexander and Bertram Muller-Myhsok and Stefan Schreiber and Thomas Meitinger and Wichmann, {Heinz Erich} and Arpo Aromaa and Eriksson, {Johan G} and Traynor, {Bryan J} and Daniah Trabzuni and Elizabeth Rossin and Kasper Lage and Jacobs, {Suzanne B R} and Gibbs, {J Raphael} and Ewan Birney and Jaakko Kaprio and Penninx, {Brenda W} and Boomsma, {Dorret I} and {van Duijn}, Cornelia and Olli Raitakari and Marjo-Riitta Jarvelin and John-Anker Zwart and Lynn Cherkas and Strachan, {David P} and Christian Kubisch and Ferrari, {Michel D} and {van den Maagdenberg}, {Arn M J M} and Martin Dichgans and Maija Wessman and Smith, {George Davey} and Kari Stefansson and Daly, {Mark J} and Nyholt, {Dale R} and Chasman, {Daniel I} and Aarno Palotie and {North American Brain Expression Consortium}",
year = "2013",
month = aug,
day = "1",
doi = "10.1038/ng.2676",
language = "English",
volume = "45",
pages = "912--7",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "8",

}

RIS

TY - JOUR

T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine

AU - Anttila, Verneri

AU - Winsvold, Bendik S

AU - Gormley, Padhraig

AU - Kurth, Tobias

AU - Bettella, Francesco

AU - McMahon, George

AU - Kallela, Mikko

AU - Malik, Rainer

AU - de Vries, Boukje

AU - Terwindt, Gisela

AU - Medland, Sarah E

AU - Todt, Unda

AU - McArdle, Wendy L

AU - Quaye, Lydia

AU - Koiranen, Markku

AU - Ikram, M Arfan

AU - Lehtimäki, Terho

AU - Stam, Anine H

AU - Ligthart, Lannie

AU - Wedenoja, Juho

AU - Dunham, Ian

AU - Neale, Benjamin M

AU - Palta, Priit

AU - Hamalainen, Eija

AU - Schürks, Markus

AU - Rose, Lynda M

AU - Buring, Julie E

AU - Ridker, Paul M

AU - Steinberg, Stacy

AU - Stefansson, Hreinn

AU - Jakobsson, Finnbogi

AU - Lawlor, Debbie A

AU - Evans, David M

AU - Ring, Susan M

AU - Färkkilä, Markus

AU - Artto, Ville

AU - Kaunisto, Mari A

AU - Freilinger, Tobias

AU - Schoenen, Jean

AU - Frants, Rune R

AU - Pelzer, Nadine

AU - Weller, Claudia M

AU - Zielman, Ronald

AU - Heath, Andrew C

AU - Madden, Pamela A F

AU - Montgomery, Grant W

AU - Martin, Nicholas G

AU - Borck, Guntram

AU - Göbel, Hartmut

AU - Heinze, Axel

AU - Heinze-Kuhn, Katja

AU - Williams, Frances M K

AU - Hartikainen, Anna-Liisa

AU - Pouta, Anneli

AU - van den Ende, Joyce

AU - Uitterlinden, Andre G

AU - Hofman, Albert

AU - Amin, Najaf

AU - Hottenga, Jouke-Jan

AU - Vink, Jacqueline M

AU - Heikkilä, Kauko

AU - Alexander, Michael

AU - Muller-Myhsok, Bertram

AU - Schreiber, Stefan

AU - Meitinger, Thomas

AU - Wichmann, Heinz Erich

AU - Aromaa, Arpo

AU - Eriksson, Johan G

AU - Traynor, Bryan J

AU - Trabzuni, Daniah

AU - Rossin, Elizabeth

AU - Lage, Kasper

AU - Jacobs, Suzanne B R

AU - Gibbs, J Raphael

AU - Birney, Ewan

AU - Kaprio, Jaakko

AU - Penninx, Brenda W

AU - Boomsma, Dorret I

AU - van Duijn, Cornelia

AU - Raitakari, Olli

AU - Jarvelin, Marjo-Riitta

AU - Zwart, John-Anker

AU - Cherkas, Lynn

AU - Strachan, David P

AU - Kubisch, Christian

AU - Ferrari, Michel D

AU - van den Maagdenberg, Arn M J M

AU - Dichgans, Martin

AU - Wessman, Maija

AU - Smith, George Davey

AU - Stefansson, Kari

AU - Daly, Mark J

AU - Nyholt, Dale R

AU - Chasman, Daniel I

AU - Palotie, Aarno

AU - North American Brain Expression Consortium

PY - 2013/8/1

Y1 - 2013/8/1

N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P<5×10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

KW - Cerebellum

KW - Computational Biology

KW - Frontal Lobe

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Migraine Disorders

KW - Polymorphism, Single Nucleotide

KW - Quantitative Trait Loci

U2 - 10.1038/ng.2676

DO - 10.1038/ng.2676

M3 - SCORING: Journal article

C2 - 23793025

VL - 45

SP - 912

EP - 917

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 8

ER -