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Genome-wide association study reveals three susceptibility loci for common migraine in the general population.

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Genome-wide association study reveals three susceptibility loci for common migraine in the general population. / Chasman, Daniel I; Schürks, Markus; Anttila, Verneri; de Vries, Boukje; Schminke, Ulf; Launer, Lenore J; Terwindt, Gisela M; Maagdenberg, van den; Arn, M J M; Fendrich, Konstanze; Völzke, Henry; Ernst, Florian; Griffiths, Lyn R; Buring, Julie E; Kallela, Mikko; Kubisch, Christian; Ridker, Paul M; Palotie, Aarno; Ferrari, Michel D; Hoffmann, Wolfgang; Zee, Robert Y L; Kurth, Tobias.

In: NAT GENET, Vol. 43, No. 7, 7, 2011, p. 695-698.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Chasman, DI, Schürks, M, Anttila, V, de Vries, B, Schminke, U, Launer, LJ, Terwindt, GM, Maagdenberg, VD, Arn, MJM, Fendrich, K, Völzke, H, Ernst, F, Griffiths, LR, Buring, JE, Kallela, M, Kubisch, C, Ridker, PM, Palotie, A, Ferrari, MD, Hoffmann, W, Zee, RYL & Kurth, T 2011, 'Genome-wide association study reveals three susceptibility loci for common migraine in the general population.', NAT GENET, vol. 43, no. 7, 7, pp. 695-698. <http://www.ncbi.nlm.nih.gov/pubmed/21666692?dopt=Citation>

APA

Chasman, D. I., Schürks, M., Anttila, V., de Vries, B., Schminke, U., Launer, L. J., Terwindt, G. M., Maagdenberg, V. D., Arn, M. J. M., Fendrich, K., Völzke, H., Ernst, F., Griffiths, L. R., Buring, J. E., Kallela, M., Kubisch, C., Ridker, P. M., Palotie, A., Ferrari, M. D., ... Kurth, T. (2011). Genome-wide association study reveals three susceptibility loci for common migraine in the general population. NAT GENET, 43(7), 695-698. [7]. http://www.ncbi.nlm.nih.gov/pubmed/21666692?dopt=Citation

Vancouver

Chasman DI, Schürks M, Anttila V, de Vries B, Schminke U, Launer LJ et al. Genome-wide association study reveals three susceptibility loci for common migraine in the general population. NAT GENET. 2011;43(7):695-698. 7.

Bibtex

@article{3c0798da5c2940b8a1aa6e49995de4ba,
title = "Genome-wide association study reveals three susceptibility loci for common migraine in the general population.",
abstract = "Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P <5 × 10(-6)) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 × 10(-9); rs10166942, OR = 0.85, P = 5.5 × 10(-12); and rs11172113, OR = 0.90, P = 4.3 × 10(-9)). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.",
keywords = "Humans, Male, Female, Middle Aged, Risk Factors, Cohort Studies, Prognosis, Case-Control Studies, Polymorphism, Single Nucleotide/genetics, United States/epidemiology, Chromosomes, Human, Pair 12/genetics, *Genetic Predisposition to Disease, *Genetic Loci, *Genome-Wide Association Study, Chromosomes, Human, Pair 1/genetics, Chromosomes, Human, Pair 2/genetics, Migraine without Aura/epidemiology/*genetics/pathology, Humans, Male, Female, Middle Aged, Risk Factors, Cohort Studies, Prognosis, Case-Control Studies, Polymorphism, Single Nucleotide/genetics, United States/epidemiology, Chromosomes, Human, Pair 12/genetics, *Genetic Predisposition to Disease, *Genetic Loci, *Genome-Wide Association Study, Chromosomes, Human, Pair 1/genetics, Chromosomes, Human, Pair 2/genetics, Migraine without Aura/epidemiology/*genetics/pathology",
author = "Chasman, {Daniel I} and Markus Sch{\"u}rks and Verneri Anttila and {de Vries}, Boukje and Ulf Schminke and Launer, {Lenore J} and Terwindt, {Gisela M} and Maagdenberg, {van den} and Arn, {M J M} and Konstanze Fendrich and Henry V{\"o}lzke and Florian Ernst and Griffiths, {Lyn R} and Buring, {Julie E} and Mikko Kallela and Christian Kubisch and Ridker, {Paul M} and Aarno Palotie and Ferrari, {Michel D} and Wolfgang Hoffmann and Zee, {Robert Y L} and Tobias Kurth",
year = "2011",
language = "English",
volume = "43",
pages = "695--698",
journal = "NAT GENET",
issn = "1061-4036",
publisher = "NATURE PUBLISHING GROUP",
number = "7",

}

RIS

TY - JOUR

T1 - Genome-wide association study reveals three susceptibility loci for common migraine in the general population.

AU - Chasman, Daniel I

AU - Schürks, Markus

AU - Anttila, Verneri

AU - de Vries, Boukje

AU - Schminke, Ulf

AU - Launer, Lenore J

AU - Terwindt, Gisela M

AU - Maagdenberg, van den

AU - Arn, M J M

AU - Fendrich, Konstanze

AU - Völzke, Henry

AU - Ernst, Florian

AU - Griffiths, Lyn R

AU - Buring, Julie E

AU - Kallela, Mikko

AU - Kubisch, Christian

AU - Ridker, Paul M

AU - Palotie, Aarno

AU - Ferrari, Michel D

AU - Hoffmann, Wolfgang

AU - Zee, Robert Y L

AU - Kurth, Tobias

PY - 2011

Y1 - 2011

N2 - Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P <5 × 10(-6)) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 × 10(-9); rs10166942, OR = 0.85, P = 5.5 × 10(-12); and rs11172113, OR = 0.90, P = 4.3 × 10(-9)). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.

AB - Migraine is a common, heterogeneous and heritable neurological disorder. Its pathophysiology is incompletely understood, and its genetic influences at the population level are unknown. In a population-based genome-wide analysis including 5,122 migraineurs and 18,108 non-migraineurs, rs2651899 (1p36.32, PRDM16), rs10166942 (2q37.1, TRPM8) and rs11172113 (12q13.3, LRP1) were among the top seven associations (P <5 × 10(-6)) with migraine. These SNPs were significant in a meta-analysis among three replication cohorts and met genome-wide significance in a meta-analysis combining the discovery and replication cohorts (rs2651899, odds ratio (OR) = 1.11, P = 3.8 × 10(-9); rs10166942, OR = 0.85, P = 5.5 × 10(-12); and rs11172113, OR = 0.90, P = 4.3 × 10(-9)). The associations at rs2651899 and rs10166942 were specific for migraine compared with non-migraine headache. None of the three SNP associations was preferential for migraine with aura or without aura, nor were any associations specific for migraine features. TRPM8 has been the focus of neuropathic pain models, whereas LRP1 modulates neuronal glutamate signaling, plausibly linking both genes to migraine pathophysiology.

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Risk Factors

KW - Cohort Studies

KW - Prognosis

KW - Case-Control Studies

KW - Polymorphism, Single Nucleotide/genetics

KW - United States/epidemiology

KW - Chromosomes, Human, Pair 12/genetics

KW - Genetic Predisposition to Disease

KW - Genetic Loci

KW - Genome-Wide Association Study

KW - Chromosomes, Human, Pair 1/genetics

KW - Chromosomes, Human, Pair 2/genetics

KW - Migraine without Aura/epidemiology/genetics/pathology

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Risk Factors

KW - Cohort Studies

KW - Prognosis

KW - Case-Control Studies

KW - Polymorphism, Single Nucleotide/genetics

KW - United States/epidemiology

KW - Chromosomes, Human, Pair 12/genetics

KW - Genetic Predisposition to Disease

KW - Genetic Loci

KW - Genome-Wide Association Study

KW - Chromosomes, Human, Pair 1/genetics

KW - Chromosomes, Human, Pair 2/genetics

KW - Migraine without Aura/epidemiology/genetics/pathology

M3 - SCORING: Journal article

VL - 43

SP - 695

EP - 698

JO - NAT GENET

JF - NAT GENET

SN - 1061-4036

IS - 7

M1 - 7

ER -