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Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer

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Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. / Painter, Jodie N.; O'Mara, Tracy A.; Marquart, Louise; Webb, Penelope M; Attia, John; Medland, Sarah E; Cheng, Timothy; Dennis, Joe; Holliday, Elizabeth G; McEvoy, Mark; Scott, Rodney J; Ahmed, Shahana; Healey, Catherine S; Shah, Mitul; Gorman, Maggie; Martin, Lynn; Hodgson, Shirley V; Ekici, Arif B; Fasching, Peter A; Hein, Alexander; Rübner, Matthias; Czene, Kamila; Darabi, Hatef; Hall, Per; Li, Jingmei; Dörk, Thilo; Dürst, Matthias; Hillemanns, Peter; Runnebaum, Ingo B; Amant, Frederic; Annibali, Daniela; Depreeuw, Jeroen; Lambrechts, Diether; Neven, Patrick; Cunningham, Julie M; Dowdy, Sean C; Goode, Ellen L; Fridley, Brooke L; Winham, Stacey J; Njølstad, Tormund S; Salvesen, Helga B; Trovik, Jone; Werner, Henrica M. J.; Ashton, Katie A; Otton, Geoffrey; Proietto, Anthony; Mints, Miriam; Tham, Emma; Bolla, Manjeet K; Michailidou, Kyriaki; Wang, Qin; Tyrer, Jonathan P; Hopper, John L; Peto, Julian; Swerdlow, Anthony J; Burwinkel, Barbara; Brenner, Hermann; Meindl, Alfons; Brauch, Hiltrud; Lindblom, Annika; Chang-Claude, Jenny; Couch, Fergus J; Giles, Graham; Kristensen, Vessela N; Cox, Angela; Pharoah, Paul D P; Tomlinson, Ian; Dunning, Alison M; Easton, Douglas F; Thompson, Deborah J.; Spurdle, Amanda B; AOCS study group.

In: CANCER EPIDEM BIOMAR, Vol. 25, No. 11, 11.2016, p. 1503-1510.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Painter, JN, O'Mara, TA, Marquart, L, Webb, PM, Attia, J, Medland, SE, Cheng, T, Dennis, J, Holliday, EG, McEvoy, M, Scott, RJ, Ahmed, S, Healey, CS, Shah, M, Gorman, M, Martin, L, Hodgson, SV, Ekici, AB, Fasching, PA, Hein, A, Rübner, M, Czene, K, Darabi, H, Hall, P, Li, J, Dörk, T, Dürst, M, Hillemanns, P, Runnebaum, IB, Amant, F, Annibali, D, Depreeuw, J, Lambrechts, D, Neven, P, Cunningham, JM, Dowdy, SC, Goode, EL, Fridley, BL, Winham, SJ, Njølstad, TS, Salvesen, HB, Trovik, J, Werner, HMJ, Ashton, KA, Otton, G, Proietto, A, Mints, M, Tham, E, Bolla, MK, Michailidou, K, Wang, Q, Tyrer, JP, Hopper, JL, Peto, J, Swerdlow, AJ, Burwinkel, B, Brenner, H, Meindl, A, Brauch, H, Lindblom, A, Chang-Claude, J, Couch, FJ, Giles, G, Kristensen, VN, Cox, A, Pharoah, PDP, Tomlinson, I, Dunning, AM, Easton, DF, Thompson, DJ, Spurdle, AB & AOCS study group 2016, 'Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer', CANCER EPIDEM BIOMAR, vol. 25, no. 11, pp. 1503-1510. https://doi.org/10.1158/1055-9965.EPI-16-0147

APA

Painter, J. N., O'Mara, T. A., Marquart, L., Webb, P. M., Attia, J., Medland, S. E., Cheng, T., Dennis, J., Holliday, E. G., McEvoy, M., Scott, R. J., Ahmed, S., Healey, C. S., Shah, M., Gorman, M., Martin, L., Hodgson, S. V., Ekici, A. B., Fasching, P. A., ... AOCS study group (2016). Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. CANCER EPIDEM BIOMAR, 25(11), 1503-1510. https://doi.org/10.1158/1055-9965.EPI-16-0147

Vancouver

Painter JN, O'Mara TA, Marquart L, Webb PM, Attia J, Medland SE et al. Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. CANCER EPIDEM BIOMAR. 2016 Nov;25(11):1503-1510. https://doi.org/10.1158/1055-9965.EPI-16-0147

Bibtex

@article{888b21cdee164f0ab87cde0b269081dd,
title = "Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer",
abstract = "BACKGROUND: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and endometrial cancer in 6,609 cases and 37,926 country-matched controls.METHODS: Logistic regression analysis and fixed effects meta-analysis were used to test for associations between endometrial cancer risk and (i) individual BMI or WHR SNPs, (ii) a combined weighted genetic risk score (wGRS) for BMI or WHR. Causality of BMI for endometrial cancer was assessed using Mendelian randomization, with BMIwGRS as instrumental variable.RESULTS: The BMIwGRS was significantly associated with endometrial cancer risk (P = 3.4 × 10(-17)). Scaling the effect of the BMIwGRS on endometrial cancer risk by its effect on BMI, the endometrial cancer OR per 5 kg/m(2) of genetically predicted BMI was 2.06 [95% confidence interval (CI), 1.89-2.21], larger than the observed effect of BMI on endometrial cancer risk (OR = 1.55; 95% CI, 1.44-1.68, per 5 kg/m(2)). The association attenuated but remained significant after adjusting for BMI (OR = 1.22; 95% CI, 1.10-1.39; P = 5.3 × 10(-4)). There was evidence of directional pleiotropy (P = 1.5 × 10(-4)). BMI SNP rs2075650 was associated with endometrial cancer at study-wide significance (P < 4.0 × 10(-4)), independent of BMI. Endometrial cancer was not significantly associated with individual WHR SNPs or the WHRwGRS.CONCLUSIONS: BMI, but not WHR, is causally associated with endometrial cancer risk, with evidence that some BMI-associated SNPs alter endometrial cancer risk via mechanisms other than measurable BMI.IMPACT: The causal association between BMI SNPs and endometrial cancer has possible implications for endometrial cancer risk modeling. Cancer Epidemiol Biomarkers Prev; 25(11); 1503-10. {\textcopyright}2016 AACR.",
keywords = "Journal Article",
author = "Painter, {Jodie N.} and O'Mara, {Tracy A.} and Louise Marquart and Webb, {Penelope M} and John Attia and Medland, {Sarah E} and Timothy Cheng and Joe Dennis and Holliday, {Elizabeth G} and Mark McEvoy and Scott, {Rodney J} and Shahana Ahmed and Healey, {Catherine S} and Mitul Shah and Maggie Gorman and Lynn Martin and Hodgson, {Shirley V} and Ekici, {Arif B} and Fasching, {Peter A} and Alexander Hein and Matthias R{\"u}bner and Kamila Czene and Hatef Darabi and Per Hall and Jingmei Li and Thilo D{\"o}rk and Matthias D{\"u}rst and Peter Hillemanns and Runnebaum, {Ingo B} and Frederic Amant and Daniela Annibali and Jeroen Depreeuw and Diether Lambrechts and Patrick Neven and Cunningham, {Julie M} and Dowdy, {Sean C} and Goode, {Ellen L} and Fridley, {Brooke L} and Winham, {Stacey J} and Nj{\o}lstad, {Tormund S} and Salvesen, {Helga B} and Jone Trovik and Werner, {Henrica M. J.} and Ashton, {Katie A} and Geoffrey Otton and Anthony Proietto and Miriam Mints and Emma Tham and Bolla, {Manjeet K} and Kyriaki Michailidou and Qin Wang and Tyrer, {Jonathan P} and Hopper, {John L} and Julian Peto and Swerdlow, {Anthony J} and Barbara Burwinkel and Hermann Brenner and Alfons Meindl and Hiltrud Brauch and Annika Lindblom and Jenny Chang-Claude and Couch, {Fergus J} and Graham Giles and Kristensen, {Vessela N} and Angela Cox and Pharoah, {Paul D P} and Ian Tomlinson and Dunning, {Alison M} and Easton, {Douglas F} and Thompson, {Deborah J.} and Spurdle, {Amanda B} and {AOCS study group}",
note = "{\textcopyright}2016 American Association for Cancer Research.",
year = "2016",
month = nov,
doi = "10.1158/1055-9965.EPI-16-0147",
language = "English",
volume = "25",
pages = "1503--1510",
journal = "CANCER EPIDEM BIOMAR",
issn = "1055-9965",
publisher = "American Association for Cancer Research Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer

AU - Painter, Jodie N.

AU - O'Mara, Tracy A.

AU - Marquart, Louise

AU - Webb, Penelope M

AU - Attia, John

AU - Medland, Sarah E

AU - Cheng, Timothy

AU - Dennis, Joe

AU - Holliday, Elizabeth G

AU - McEvoy, Mark

AU - Scott, Rodney J

AU - Ahmed, Shahana

AU - Healey, Catherine S

AU - Shah, Mitul

AU - Gorman, Maggie

AU - Martin, Lynn

AU - Hodgson, Shirley V

AU - Ekici, Arif B

AU - Fasching, Peter A

AU - Hein, Alexander

AU - Rübner, Matthias

AU - Czene, Kamila

AU - Darabi, Hatef

AU - Hall, Per

AU - Li, Jingmei

AU - Dörk, Thilo

AU - Dürst, Matthias

AU - Hillemanns, Peter

AU - Runnebaum, Ingo B

AU - Amant, Frederic

AU - Annibali, Daniela

AU - Depreeuw, Jeroen

AU - Lambrechts, Diether

AU - Neven, Patrick

AU - Cunningham, Julie M

AU - Dowdy, Sean C

AU - Goode, Ellen L

AU - Fridley, Brooke L

AU - Winham, Stacey J

AU - Njølstad, Tormund S

AU - Salvesen, Helga B

AU - Trovik, Jone

AU - Werner, Henrica M. J.

AU - Ashton, Katie A

AU - Otton, Geoffrey

AU - Proietto, Anthony

AU - Mints, Miriam

AU - Tham, Emma

AU - Bolla, Manjeet K

AU - Michailidou, Kyriaki

AU - Wang, Qin

AU - Tyrer, Jonathan P

AU - Hopper, John L

AU - Peto, Julian

AU - Swerdlow, Anthony J

AU - Burwinkel, Barbara

AU - Brenner, Hermann

AU - Meindl, Alfons

AU - Brauch, Hiltrud

AU - Lindblom, Annika

AU - Chang-Claude, Jenny

AU - Couch, Fergus J

AU - Giles, Graham

AU - Kristensen, Vessela N

AU - Cox, Angela

AU - Pharoah, Paul D P

AU - Tomlinson, Ian

AU - Dunning, Alison M

AU - Easton, Douglas F

AU - Thompson, Deborah J.

AU - Spurdle, Amanda B

AU - AOCS study group

N1 - ©2016 American Association for Cancer Research.

PY - 2016/11

Y1 - 2016/11

N2 - BACKGROUND: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and endometrial cancer in 6,609 cases and 37,926 country-matched controls.METHODS: Logistic regression analysis and fixed effects meta-analysis were used to test for associations between endometrial cancer risk and (i) individual BMI or WHR SNPs, (ii) a combined weighted genetic risk score (wGRS) for BMI or WHR. Causality of BMI for endometrial cancer was assessed using Mendelian randomization, with BMIwGRS as instrumental variable.RESULTS: The BMIwGRS was significantly associated with endometrial cancer risk (P = 3.4 × 10(-17)). Scaling the effect of the BMIwGRS on endometrial cancer risk by its effect on BMI, the endometrial cancer OR per 5 kg/m(2) of genetically predicted BMI was 2.06 [95% confidence interval (CI), 1.89-2.21], larger than the observed effect of BMI on endometrial cancer risk (OR = 1.55; 95% CI, 1.44-1.68, per 5 kg/m(2)). The association attenuated but remained significant after adjusting for BMI (OR = 1.22; 95% CI, 1.10-1.39; P = 5.3 × 10(-4)). There was evidence of directional pleiotropy (P = 1.5 × 10(-4)). BMI SNP rs2075650 was associated with endometrial cancer at study-wide significance (P < 4.0 × 10(-4)), independent of BMI. Endometrial cancer was not significantly associated with individual WHR SNPs or the WHRwGRS.CONCLUSIONS: BMI, but not WHR, is causally associated with endometrial cancer risk, with evidence that some BMI-associated SNPs alter endometrial cancer risk via mechanisms other than measurable BMI.IMPACT: The causal association between BMI SNPs and endometrial cancer has possible implications for endometrial cancer risk modeling. Cancer Epidemiol Biomarkers Prev; 25(11); 1503-10. ©2016 AACR.

AB - BACKGROUND: The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent of measured BMI, we investigated relationships between 77 BMI and 47 WHR SNPs and endometrial cancer in 6,609 cases and 37,926 country-matched controls.METHODS: Logistic regression analysis and fixed effects meta-analysis were used to test for associations between endometrial cancer risk and (i) individual BMI or WHR SNPs, (ii) a combined weighted genetic risk score (wGRS) for BMI or WHR. Causality of BMI for endometrial cancer was assessed using Mendelian randomization, with BMIwGRS as instrumental variable.RESULTS: The BMIwGRS was significantly associated with endometrial cancer risk (P = 3.4 × 10(-17)). Scaling the effect of the BMIwGRS on endometrial cancer risk by its effect on BMI, the endometrial cancer OR per 5 kg/m(2) of genetically predicted BMI was 2.06 [95% confidence interval (CI), 1.89-2.21], larger than the observed effect of BMI on endometrial cancer risk (OR = 1.55; 95% CI, 1.44-1.68, per 5 kg/m(2)). The association attenuated but remained significant after adjusting for BMI (OR = 1.22; 95% CI, 1.10-1.39; P = 5.3 × 10(-4)). There was evidence of directional pleiotropy (P = 1.5 × 10(-4)). BMI SNP rs2075650 was associated with endometrial cancer at study-wide significance (P < 4.0 × 10(-4)), independent of BMI. Endometrial cancer was not significantly associated with individual WHR SNPs or the WHRwGRS.CONCLUSIONS: BMI, but not WHR, is causally associated with endometrial cancer risk, with evidence that some BMI-associated SNPs alter endometrial cancer risk via mechanisms other than measurable BMI.IMPACT: The causal association between BMI SNPs and endometrial cancer has possible implications for endometrial cancer risk modeling. Cancer Epidemiol Biomarkers Prev; 25(11); 1503-10. ©2016 AACR.

KW - Journal Article

U2 - 10.1158/1055-9965.EPI-16-0147

DO - 10.1158/1055-9965.EPI-16-0147

M3 - SCORING: Journal article

C2 - 27550749

VL - 25

SP - 1503

EP - 1510

JO - CANCER EPIDEM BIOMAR

JF - CANCER EPIDEM BIOMAR

SN - 1055-9965

IS - 11

ER -